Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy

Yamashita, Yoshiki; Suzuki, Kei; Mastumoto, Takeshi; Itō, Makoto; Ohishi, Koji; Katayama, Naoyuki; Suzuki‐Inoue, Katsue; Wada, Hideo

doi:10.1016/j.thromres.2019.03.018

Cited by 24 publications

(26 citation statements)

References 23 publications

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“…The high plasma sCLEC-2 levels in patients with lacunar ACI (a small infarction) or TIA, suggest that sCLEC-2 has a high sensitivity in the diagnosis of an ischemic attack. The plasma sCLEC-2 levels were markedly high in patients with TMA, DIC, and acute coronary syndrome [ 12 , 13 , 14 ], suggesting that elevated sCLEC-2 levels might reflect platelet activation and that they may not directly reflect infarction. As the plasma sCLEC-2 levels were high in patients with lacunar ACI or TIA, these levels might be high in patients with non-symptomatic ACI [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Soluble C-type lectin-like receptor 2 (sCLEC-2) is released upon platelet activation [ 10 ] and it has been introduced as new biomarker of platelet activation. Soluble C-type lectin-like receptor 2 (sCLEC-2) has been thus introduced as new biomarkers of platelet activation [ 11 , 12 ]. Elevated plasma levels of sCLEC-2 were reported in patient with thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC) [ 12 ], as well as patients with acute coronary syndrome [ 13 , 14 ] and acute ischemic stroke [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction

Nishigaki

Ichikawa

Ezaki

et al. 2021

JCM

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Background: Acute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer levels were measured using the STACIA system. Results: The plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis. Conclusion: Using both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction

Nishigaki

Ichikawa

Ezaki

et al. 2021

JCM

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“…Although DIC is generally considered to be induced by the activation of coagulation [20], the activation of platelets may also be responsible for DIC. sCLEC2 levels are essential platelet-activating receptors in thrombosis, and elevated levels have been reported in many cases for TMA and a small number of cases for DIC [11,14].…”

Section: Discussionmentioning

confidence: 99%

“…The correlation of sCLEC-2 levels with platelet count was poor in the present study. While the plasma sCLEC-2 levels are usually considered to be correlated with platelet count in patients without platelet consumption [14], marked consumption of platelets is observed in DIC and Pre-DIC [20].…”

Section: Discussionmentioning

confidence: 99%

“…Although the β-thromboglobulin (β-TG), platelet factor 4 (PF4), and P-selectine are the candidates of biomarkers for platelet activation, their actual diagnostic specificity for thrombosis due to platelet activation is not high, and they have little clinical laboratory use. Soluble platelet membrane glycoprotein VI (sGPVI) and soluble C-type lectin-like receptor 2 (sCLEC-2) have thus been introduced as new biomarkers of platelet activation [11][12][13][14], and the elevation of sGPVI and sCLEC-2 is reported in TMA [11,14]. Other than TMA, elevated plasma levels of sGPVI have been reported in postoperative patients [12] and patients with acute coronary syndrome [15].…”

Section: Introductionmentioning

confidence: 99%

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Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation

Yamamoto

Wada

Ichkawa

et al. 2021

JCM

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Disseminated intravascular coagulation (DIC) is induced by excess activation coagulation, and activated platelets are also involved in pathogenesis. Therefore, plasma levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a new marker for platelet activation, can be expected as a marker of DIC in critically ill patients. Plasma levels of sCLEC-2 and D-dimer were measured using the STACIA system. Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with underlying diseases of DIC than in those with unidentified clinical syndrome (UCS). Plasma sCLEC-2 levels were significantly higher in the patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. Similarly, plasma D-dimer levels were also significantly higher in patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. The plasma sCLEC-2 levels in all patients and those with a DIC score ≤ 4 were significantly higher in non-survivors than survivors. The plasma D-dimer levels in all patients, those with a DIC score ≥ 5 and those with a DIC score ≤ 4, were significantly higher in non-survivors than in survivors. The plasma sCLEC-2 is expected as a marker for DIC/Pre-DIC as well as the prognostic marker in critically ill patients.

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Thromboinflammation in acute injury: infections, heatstroke, and trauma

Iba

Boisramé-Helms

Levi

et al. 2024

Journal of Thrombosis and Haemostasis

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Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy

Cited by 24 publications

References 23 publications

Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction

Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction

Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation

Thromboinflammation in acute injury: infections, heatstroke, and trauma

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