Elevated PTTG1 predicts poor prognosis in kidney renal clear cell carcinoma and correlates with immunity

Zhang, Xinyu; Ji, Hao; Huang, Yeqing; Zhu, Bingye; Xing, Qianwei

doi:10.1016/j.heliyon.2023.e13201

Cited by 6 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, the estimate from the Gaidai‐Xing approach was compared to the level of the probability

p\ = {10}^{ - 3.5}\

, associated with this contour line. It was observed that the estimating results of the probability level by ACER2D was within the 95% Confidence Interval (CI) estimated by Gaidai‐Xing 26,64–70 …”

Section: Resultsmentioning

confidence: 52%

On safe offshore energy exploration in the Gulf of Eilat

Sun

Gaidai

Xing

et al. 2023

Quality & Reliability Eng

View full text Add to dashboard Cite

Gulf of Eilat is rich with energy resources, however any industrial natural resource development requires additional safety, as local eco‐system has to be preserved. In contrast to bivariate reliability approaches, known to their accurate predictions of extreme response and load levels for two‐dimensional dynamic systems, this study suggests and validates novel structural reliability method, which is being appropriate method for high‐dimensional dynamic systems. Conventional reliability methods do not have an advantage of dealing easily with high‐dimensional nonlinear dynamic systems, especially with non‐linear cross‐correlations between different system components. Advocated approach does not have limitations on the system's number of degrees of freedom, and it can accurately assess dynamic system's failure risks. Main purpose of this study was to benchmark state‐of‐the‐art reliability methodology, while utilizing available dataset efficiently. Note that advocated approach is not limited to offshore engineering example, studied here, and it has wide range of potential engineering and design applications.

show abstract

“…Then, the estimate from the Gaidai‐Xing approach was compared to the level of the probability

p\ = {10}^{ - 3.5}\

Section: Resultsmentioning

confidence: 52%

On safe offshore energy exploration in the Gulf of Eilat

Sun

Gaidai

Xing

et al. 2023

Quality & Reliability Eng

View full text Add to dashboard Cite

show abstract

“…This is consistent with the result that s‐SKI‐Ab and s‐TMED5‐Ab levels showed opposite effects on the overall survival of patients with esophageal carcinoma (Figure 3A–C), if the serum antibody levels are associated with the protein expression levels. Some other reports have shown that the high autoantibody titers were accompanied by the high expression of their antigenic proteins in cancer tissues 11,12,44,45 …”

Section: Discussionmentioning

confidence: 97%

Combination of high anti‐SKI and low anti‐TMED5 antibody levels is preferable prognostic factor in esophageal carcinoma

Ito,

Yajima,

Suzuki

et al. 2024

Cancer Science

View full text Add to dashboard Cite

Given that esophageal cancer is highly malignant, the discovery of novel prognostic markers is eagerly awaited. We performed serological identification of antigens by recombinant cDNA expression cloning (SEREX) and identified SKI proto‐oncogene protein and transmembrane p24 trafficking protein 5 (TMED5) as antigens recognized by serum IgG antibodies in patients with esophageal carcinoma. SKI and TMED5 proteins were expressed in Escherichia coli, purified by affinity chromatography, and used as antigens. The serum anti‐SKI antibody (s‐SKI‐Ab) and anti‐TMED5 antibody (s‐TMED5‐Ab) levels were significantly higher in 192 patients with esophageal carcinoma than in 96 healthy donors. The presence of s‐SKI‐Abs and s‐TMED5‐Abs in the patients' sera was confirmed by western blotting. Immunohistochemical staining showed that the TMED5 protein was highly expressed in the cytoplasm and nuclear compartments of the esophageal squamous cell carcinoma tissues, whereas the SKI protein was localized predominantly in the nuclei. Regarding the overall survival in 91 patients who underwent radical surgery, the s‐SKI‐Ab‐positive and s‐TMED5‐Ab‐negative statuses were significantly associated with a favorable prognosis. Additionally, the combination of s‐SKI‐Ab‐positive and s‐TMED5‐Ab‐negative cases showed an even clearer difference in overall survival as compared with that of s‐SKI‐Ab‐negative and s‐TMED5‐Ab‐positive cases. The s‐SKI‐Ab and s‐TMED5‐Ab biomarkers are useful for diagnosing esophageal carcinoma and distinguishing between favorable and poor prognoses.

show abstract

“…Thus L being random process (variable), representing dynamic system lifetime. [ 15–22 ] In particular, when the number of system dimensions (failure modes) was high, modern engineering reliability methodologies did not provide a formula to analyze service level agreements of complex energy systems. In theory, it was eligible to assess target cumulative density function

\begin{eqnarray}{\rm{LTD\ }}\left( L \right) = {\rm{Prob}}\left( {{\rm{Lifetime}} \le L} \right)\end{eqnarray}

an easy manner for a complicated environmental system, employing either enough measurement data or direct Monte Carlo simulations.…”

Section: Methodsmentioning

confidence: 99%

Carbon Storage Tanker Lifetime Assessment

Gaidai

et al. 2023

Global Challenges

View full text Add to dashboard Cite

CO 2 capture and storage (CCS) is an important strategy to reduce global CO 2 emissions. This work presents both cutting-edge carbon storage tanker design, as well as novel reliability method making possible to extract useful information about the lifespan distribution of carbon capture systems from their recorded time history. The method outlined may be applied on more complex sustainable systems that are exposed to environmental stresses throughout the whole period of their planned service life. The latter is of paramount importance at the design stage for complex engineering systems. Novel design for CCS system is discussed and accurate numerical simulation results are used to apply suggested novel reliability methodology. Furthermore, traditional reliability approaches that deal with complex energy systems are not well suited for handling high dimensionality and cross-correlation between various system components of innovative dynamic CO 2 storage subsea shuttle tanker. This study has two distinctive key features: the state of art CCS design concept, and the novel general purpose reliability method, recently developed by authors, and particularly suitable for operational safety study of complex energy systems.

show abstract

Elevated PTTG1 predicts poor prognosis in kidney renal clear cell carcinoma and correlates with immunity

Cited by 6 publications

References 50 publications

On safe offshore energy exploration in the Gulf of Eilat

On safe offshore energy exploration in the Gulf of Eilat

Combination of high anti‐SKI and low anti‐TMED5 antibody levels is preferable prognostic factor in esophageal carcinoma

Carbon Storage Tanker Lifetime Assessment

Contact Info

Product

Resources

About