Elevated pulmonary arterial elastance and right ventricular uncoupling are associated with greater mortality in advanced heart failure

Catching the wave at the wrong time: Arrival timing provides additional insight into right ventricular afterload in pulmonary arterial hypertension

“…Cross‐sectional studies across a spectrum of pulmonary vascular haemodynamic states, from healthy controls to PAH and pulmonary hypertension due to left heart disease, may help delineate the contributions of vascular resistance and compliance to Zc and wave speed. We recently observed differences in the relative timing of peak RV systolic pressure in adults with left heart failure compared to healthy controls, which were associated with PA pressure (Wright et al ., 2020). Acute interventions to perturb the pulmonary vasculature such as alveolar hypoxia and/or inhaled nitric oxide may provide additional mechanistic insight into the relationship between PA structure and function and RV function and adaptation in health and disease.…”

A step in the right direction: pressure‐volume relationships provide insight into right ventricular performance during exercise in healthy adults

“…Control E es and E a values in this study agreed well with a recent study including healthy adults at rest (Wright et al . 2020). Studies of prospectively recruited healthy volunteers are critical to understand normal physiology, and advance upon the growing literature derived from referred patient controls.…”

Predicting, Recognizing, and Treating Right Heart Failure in Patients Undergoing Durable LVAD Therapy

“…As afterload increases, RV stroke volume declines resulting in greater energy expenditure. This phenomenon of decreased mechanical efficiency and increased oxygen consumption to maintain adequate RV output is termed right ventricular-pulmonary artery (RV-PA) uncoupling and can be a harbinger for adverse outcomes [ 19 , 20 ].…”