Elevated S100A9 expression in chronic rhinosinusitis coincides with elevated MMP production and proliferation in vitro

Boruk, Marina; Railwah, Christopher; Lora, Alnardo; Nath, Sridesh; Wu, Derek; Chow, Lillian; Borhanjoo, P.; Dabo, Abdoulaye; Chowdhury, Sadakat; Kaiser, R.; Foronjy, Robert; Rosenfeld, Richard M.; Geraghty, Patrick

doi:10.1038/s41598-020-73480-8

Cited by 16 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abnormal expression of S100A9 has been reported to be connected with inflammatory responses. Boruk et al found that elevated expression of S100A9 in chronic rhinosinusitis coincided with elevated matrix metalloproteinase production and proliferation in vitro [ 23 ]; moreover, circulating levels of S100A8/A9 could show intraocular inflammation in uveitis patients [ 24 ]. S100A9 is also associated with tumors; a study suggests that it plays a pivotal part in establishing an immunosuppressive tumor microenvironment by stimulating chemotaxis and activation of myeloid-derived suppressor cells (MDSCs).…”

Section: Introductionmentioning

confidence: 99%

Three Potential Tumor Markers Promote Metastasis and Recurrence of Colorectal Cancer by Regulating the Inflammatory Response: ADAM8, LYN, and S100A9

Liu

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Metastasis and recurrence are major causes of colorectal cancer (CRC) death, but their molecular mechanisms are unclear. In this study, genes associated with CRC metastasis and recurrence were identified by weighted gene coexpression network analysis, selecting the top 25% most variant genes in the dataset GSE33113. By average linkage hierarchical clustering, a total of 21 modules were generated. One key module was identified as the most relevant to the prognosis of CRC. Gene Ontology analysis indicated that genes associated with tumor metastasis and recurrence in this module were significantly enriched in inflammatory biological functions. Functional analysis was performed on the key module, and candidate hub genes (ADAM8, LYN, and S100A9) were screened out by expression and survival analysis. In summary, the three core genes identified in this study could greatly improve our understanding of CRC metastasis and recurrence. The results also provide a theoretical basis for the use of three core genes (ADAM8, LYN, and S100A9) as a combined marker for early diagnosis, which could benefit CRC patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Three Potential Tumor Markers Promote Metastasis and Recurrence of Colorectal Cancer by Regulating the Inflammatory Response: ADAM8, LYN, and S100A9

Liu

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…Research has proved that the upregulation of MMPs expression in PF can break out the balance of MMPs/TIMPs, which can be a major mechanism related to PF [ 39 ]. Previous studies have demonstrated that MMP3 and MMP7 promote PF by downregulation of antifibrotic mediators, upregulation of profibrotic mediators, and promotion of cell migration in animal models [ 40 ]. The primary function of TIMP-1 is to suppress MMPs activity [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Jinlian Xiaodu Decoction Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats

Tao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Jinlian Xiaodu Decoction (JXD) was reported to have anti-inflammatory and lung protection effects. This study aimed to explore the role and mechanism of JXD on bleomycin (BLM)-induced pulmonary fibrosis (PF). Methods. The UHPLC-Q/TOF-MS system was applied to analyze JXD composition. The PF model was established by BLM intratracheal administration in Wistar rats. Subsequently, BLM-treated rats were intragastrically administered with dexamethasone (DXM, 1 g/kg/d) or JXD (3.5, 7 or 14 g/kg/d). Next, the lung coefficient was calculated; H&E, Masson, and TUNEL staining were used for lung morphological analysis and apoptosis assessment. Bronchoalveolar lavage fluid (BALF) biochemical analysis was conducted to count the inflammatory cell number. The expression of inflammatory factors mRNA in the lung tissue and BALF were measured by qRT-PCR. The content and activity of oxidative stress-related proteins were detected. The expression of PF-related, apoptosis-related, and TGF-β1 pathway-related protein were assessed by immunohistochemistry or Western blot. Results. Twenty-six compounds were identified from JXD in both negative and positive ion modes. In BLM-induced rats, JXD reduced the lung coefficient and alleviated PF injury. JXD decreased inflammatory cell count and TNF-α, IL-1β, IL-6, and MCP-1 content. Meanwhile, JXD blunted BLM-induced oxidative stress and a high level of HYP. Furthermore, TUNEL analysis found that JXD inhibited cell apoptosis and increased Bcl-2/Bax ratio in BLM-induced lung. Moreover, JXD relieved the role of BLM on α-SMA, TGF-β1, collagen I, fibronectin, E-cadherin protein expression, and the phosphorylation of Smad2/3 in PF rat. Conclusion. This study revealed the protective effect and possible element of JXD on BLM-caused PF.

show abstract

“…Related literature has reported that MMP3 promoted the development of serrated polyps, although this requires further research. Several studies have observed that MMPs were potential biomarkers (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Analysis of dynamic molecular networks: the progression from colorectal adenoma to cancer

Jiang¹,

Song²,

Hu³

et al. 2021

J Gastrointest Oncol

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) is one of the deadliest cancers worldwide. It is the fourth most deadly cancer in the world with nearly 900,000 people die every year, the progression of polyps into cancer as one of its most common developmental pathways.Methods: This study obtained gene chip data collections from the Gene Expression Omnibus for colorectal adenoma (GSE8671) and colorectal cancer (GSE32323). Differentially expressed genes (DEGs) in normal tissue and different stages of CRC were analyzed for clustering, comparison, and visualization using R software. The Cytoscape plugin DyNetViewer was used to construct a dynamic protein-protein interaction network. Subsequently, through the Database for Annotation, Visualization and Integrated Discovery, the DEGs were functionally annotated and path enriched.Results: Our study found that the matrix metalloprotein family and chemokines were the key regulatory genes that drove CRC progression. The Wnt signaling pathway, chemokine signaling pathway, and CRC pathway were the pathological pathways for CRC. Maintenance played an important role in this process.In addition, the related nodes and pathways at various stages may be potential mechanisms for promoting dynamic CRC progression. Conclusions:Our study provides a better understanding of the dynamic pattern of molecular interaction networks during CRC progression and provides relevant markers for more accurate screening of cancer in polyps.

show abstract

Elevated S100A9 expression in chronic rhinosinusitis coincides with elevated MMP production and proliferation in vitro

Cited by 16 publications

References 40 publications

Three Potential Tumor Markers Promote Metastasis and Recurrence of Colorectal Cancer by Regulating the Inflammatory Response: ADAM8, LYN, and S100A9

Three Potential Tumor Markers Promote Metastasis and Recurrence of Colorectal Cancer by Regulating the Inflammatory Response: ADAM8, LYN, and S100A9

Jinlian Xiaodu Decoction Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats

Analysis of dynamic molecular networks: the progression from colorectal adenoma to cancer

Contact Info

Product

Resources

About