Elevated S100B levels in schizophrenia are associated with insulin resistance

Steiner, Johann; Walter, Martin; Guest, Paul C.; Myint, Aye-Mu; Schiltz, Kolja; Panteli, Benjamin; Brauner, Mareike; Bernstein, Hans‐Gert; Gos, Tomasz; Herberth, Marlis; Schroeter, Matthias L.; Schwarz, Markus J.; Westphal, Sabine; Bahn, Sabine; Bogerts, Bernhard

doi:10.1038/mp.2009.87

Cited by 61 publications

(49 citation statements)

References 10 publications

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“…S100B is secreted by adipocytes and is involved in the pathogenesis of obesity as shown in vitro (Fujiya et al, 2014) and in vivo (Buckman et al, 2014). Positive correlation of serum S100B with BMI was previously reported in a combined sample of cognitively intact lean and obese subjects (Steiner et al, 2010a) and in subjects with schizophrenia (Steiner et al, 2010b). In our study the positive correlation in the whole sample was likely driven by the healthy subgroup, with no such association in minor depressive episode.…”

Section: Discussionmentioning

confidence: 43%

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

et al. 2016

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Minor depression is diagnosed when a patient suffers from 2 to 4 depressive symptoms for at least 2 weeks. Though minor depression is a widespread phenomenon, its pathophysiology has hardly been studied. To get a first insight into the pathophysiological mechanisms underlying this disorder we assessed serum levels of biomarkers for plasticity, glial and neuronal function: brain-derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE). 27 subjects with minor depressive episode and 82 healthy subjects over 60 years of age were selected from the database of the Leipzig population-based study of civilization diseases (LIFE). Serum levels of BDNF, S100B and NSE were compared between groups, and correlated with age, body-mass index (BMI), and degree of white matter hyperintensities (score on Fazekas scale). S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10-0.66). NSE correlated with Fazekas score in patients with minor depression (r s = 0.436, p = 0.048) and in the whole sample (r s = 0.252, p = 0.019). S100B correlated with BMI (r s = 0.246, p = 0.031) and with age in healthy subjects (r s = 0.345, p = 0.002). Increased S100B in males with minor depression, without alterations in BDNF and NSE, supports the glial hypothesis of depression. Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

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Section: Discussionmentioning

confidence: 43%

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

et al. 2016

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“…Moreover, no correlation was found with BMI. Interestingly, this lack of correlation was also observed in schizophrenic patients and attributed to insulin resistance in these patients (Steiner et al, 2010b). However, augmented S100B was correlated with the severity of suicidal ideation in adolescents with psychosis or mood disorders (Falcone et al, 2010).…”

Section: Tablementioning

confidence: 96%

Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders

Cantarelli

Nardin

Buffon

et al. 2015

Journal of Affective Disorders

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“…Early studies show expression of S100B protein in pre-and mature-adipocyte and is induced during adipogenesis 62,63 . Physiological S100B levels appear to closely reflect adipose tissue mass or insulin resistance in humans [64][65][66] . HMGB1 is also found to be expressed in human adipose tissue with the expression level associated with the fat mass and obesity-associated gene 67 .…”

Section: Endogenous Rage Ligands Insulin Resistance and Metabolic Symentioning

confidence: 99%

AGE/RAGE as a Mediator of Insulin Resistance or Metabolic Syndrome: Another Aspect of Metabolic Memory?

Koyama¹,

Yamamoto²

2012

Biomedical Science, Engineering and Technology

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Elevated S100B levels in schizophrenia are associated with insulin resistance

Cited by 61 publications

References 10 publications

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

First Evidence For Glial Pathology In Late Life Minor Depression: s100b Is Increased In Males With Minor Depression

Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders

AGE/RAGE as a Mediator of Insulin Resistance or Metabolic Syndrome: Another Aspect of Metabolic Memory?

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