Elevated serum angiotensin-converting enzyme activity in onchocerciasis

Ronday, M. J. H.; Lelij, Allegonda Van der; Wienesen, M.; Rothova, Aniki; Stilma, J. S.; Kijlstra, Aize

doi:10.1007/bf00164636

Cited by 3 publications

(3 citation statements)

References 7 publications

(8 reference statements)

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“…34,35 Lung disease and some parasites can raise ACE; onchocerciasis, which is associated with elevated ACE, is endemic in Nigeria and might have contributed to the higher mean levels. 36 Using larger family sets, Rice et al 37 examined heterogeneity of the familial relationships for BP in the Quebec Family Study and the Tecumseh Community Health Study. With the Tau model, higher spouse correlations were detected for SBP in Quebec, with similar familiality (Ϸ40%), whereas for DBP, familiality was substantially higher in Quebec (Ϸ60%) than in Tecumseh (Ϸ25%), leading to the interpretation of a larger effect of household environment in Quebec.…”

Section: Discussionmentioning

confidence: 99%

Heritability of Angiotensin-Converting Enzyme and Angiotensinogen

et al. 2000

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Abstract-Angiotensinogen (AGT) and angiotensin I-converting enzyme (ACE) are heritable traits, but whether the environmental context influences heritability has not been examined. Known genetic factors explain only a portion of variation in AGT and ACE, and levels of both proteins are influenced by the environment. The African diaspora provides an opportunity to compare these traits in genetically related populations in contrasting environments. , and correlations among first-degree relatives were large (0.42 to 0.51 and 0.36 to 0.38 for AGT and ACE, respectively). Among African Americans, the familial aggregations of AGT and ACE were very limited, and the familial correlation for AGT was not different from zero. Heritability was 77% for AGT and 67% for ACE in Nigeria and 18% for AGT and ACE in the United States. The familial patterns of body mass index and blood pressure were similar among both family sets. In conclusion, less familial aggregation was observed for AGT and ACE in the United States than in Nigeria, most likely reflecting a greater random individual environmental effect on these traits. Variation in heritability of traits could influence the power of epidemiological studies to identify genetic effects.

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Section: Discussionmentioning

confidence: 99%

Heritability of Angiotensin-Converting Enzyme and Angiotensinogen

et al. 2000

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“…Determination of fibroblast procollagen production in vitro and total lung collagen in vivo. Fibroblast procollagen production was assessed via the determination of hydroxyproline by HPLC, as previously described (29,39). Briefly, proteins in the cell layer and medium were precipitated in ethanol and separated from free amino acids by filtration through an acid-resistant 0.45-m pore filter (type HV, Millipore).…”

Section: Methodsmentioning

confidence: 99%

Angiotensin II and the fibroproliferative response to acute lung injury

Marshall¹,

Gohlke²,

Chambers³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

241

191

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Angiotensin II (ANG II), generated by activation of local renin-angiotensin systems, is believed to play an important role in tissue repair and remodeling, in part via transforming growth factor-beta (TGF-beta). Angiotensin-converting enzyme (ACE) inhibitors have been shown to abrogate experimental lung injury via a number of potential mechanisms; however, the potentially fibroproliferative role for ANG II in the lung has not been characterized. We hypothesized that, after lung injury, ANG II would stimulate fibroblast procollagen synthesis and promote lung collagen deposition in rats. In vitro, ANG II was a potent inducer of procollagen production in human lung fibroblasts via activation of the type 1 receptor and, at least in part, via the autocrine action of TGF-beta. After bleomycin-induced lung injury, an increase in lung ANG II concentration was observed by day 3 that preceded increases in lung collagen and was maintained until death at day 21. Administration of an ACE inhibitor (ramipril) reduced ACE activity, ANG II concentration, TGF-beta expression, and collagen deposition. Losartan (an ANG II type 1 receptor antagonist) also attenuated the increase in TGF-beta expression and lung collagen deposition. These observations suggest that ANG II, possibly generated locally within the lung, may play an important role in the fibrotic response to acute lung injury, at least in part via the action of TGF-beta. ACE inhibitors and receptor antagonists, already widely used clinically, should be assessed as potential new therapies for fibrotic lung disease.

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“…Previous unsuccessful attempts have been made to resolve the problem associated with onchocerciasis diagnosis. Such attempts were the assessment of two or more clinical manifestations of the disease (Gemade and Utsalo, 1990;Kelly and Akogun, 1997), provision of large quantities of onchocercal antigens by cloning for serodiagnosis (Chandrashaker et al, 1991(Chandrashaker et al, , 1996, the use of polymerase chain reaction method to identify onchocercal specific complement DNA (Zimmerman et al, 1994) especially in superficial bloodless skin scrapping (Toel et al, 1998) and the monitoring of the elevated serum angiotensin (Ronday et al, 1996). However, the search for a sensitive diagnostic tool has hitherto been rendered illusive by many varying clinical manifestations of the disease in patients (Cohen and Warren, 1982).…”

Section: Introductionmentioning

confidence: 99%

Comparison Of Clinical, Parasitological And Serological Diagnostic Methods For The Definitive Diagnosis Of Onchocerciasis In Nsukka Senatorial Zone

Uzoegwu

Aloh

2008

Anim. Res. Int.

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Clinical, parasitological and serological diagnostic methods were compared for de initive diagnosis of human onchocerciasis in three endemic communities o Nkpologu, Ukpabi and Obimo; located at d f ering distances from the bank of Adada river in Nsukka senatorial zone of Enugu State, Nigeria. The results revealed that 43.98%, 2.78%, 57.60% and 76.55% o the total number o volunteers tested were positive by most common and rare clinical symptoms, skin biopsy and Enzyme-linked immunosorbent assay (ELISA) respectively. O those seropositive, 86.02% had microfilariae in their skin. Similarly, 67.28% and 91 91% o those who were pos tive by ELISA and skin biopsy respective y displayed onchocercal nodules either on the head trunk, groin, laps or near the knee. However, 96.76% of those with nodules had microfilariae in their skin. The results further showed that the inc dence o onchocerciasis and worm burden in the three communities vary inversely with their respective d s ances from the river. Considering the relative significance of these methods in the diagnosis of onchocerciasis, we recommend the use o a combination of the most common clinical manifestations, skin biopsy and ELISA in the diagnosis of onchocerciasis, at least for epidemiological studies, until a single definitive diagnostic method is developed.

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Elevated serum angiotensin-converting enzyme activity in onchocerciasis

Cited by 3 publications

References 7 publications

Heritability of Angiotensin-Converting Enzyme and Angiotensinogen

Heritability of Angiotensin-Converting Enzyme and Angiotensinogen

Angiotensin II and the fibroproliferative response to acute lung injury

Comparison Of Clinical, Parasitological And Serological Diagnostic Methods For The Definitive Diagnosis Of Onchocerciasis In Nsukka Senatorial Zone

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