Elevated Serum CA-125 in a Patient with Follicular Lymphoma and a History of Ovarian Cancer

Anand, Rachna; Markman, Maurie

doi:10.1159/000327322

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…A case report of a patient with a history of ovarian cancer specifically linked elevated CA 125 levels to the patient's new follicular lymphoma diagnosis, rather than to ovarian cancer. 5 Our patient underwent combined laparoscopic cholecystectomy for symptomatic cholelithiasis and splenectomy for massive splenomegaly. The surgery was performed by the staff surgeon with the assistance of a chief resident.…”

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confidence: 92%

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A laparoscopic approach to address massive splenomegaly, symptomatic cholelithiasis, and a planned postoperative pregnancy: A case report

Bishop

Krohn

Vakayil

et al. 2023

Clinical Case Reports

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We aimed to demonstrate that surgery can be tailored to address a patient's unique medical and surgical issues. Our patient presented with severe symptomatic cholelithiasis and massive splenomegaly; she had additionally planned for pregnancy shortly after surgery. A combined laparoscopic cholecystectomy and splenectomy was proposed to avoid large abdominal incisions immediately prior to the planned pregnancy. No procedural complications were observed, and the patient successfully carried a healthy pregnancy to term within 1 year of surgery. We have provided supplemental data from the National Surgical Quality Improvement Program (NSQIP) database that compares the complication rates between laparoscopic splenectomy (LS) and open splenectomy (OS) for thrombocytopenia. These data support the safety and efficacy of LS.We discovered two related studies on splenectomy for thrombocytopenia from the literature. A NSQIP study published in 2013 compared patients who had undergone LS and OS and were cared for prior to 2010. A metaanalysis published in 2021 summarized the data from smaller reported series. 1,2 This case report and NSQIP study compared the expected complications and patient outcomes for LS and OS in this era, where LS is the standard approach. This study demonstrates the value of a tailored surgical approach. In addition, our supplemental NSQIP data reinforce the safety of LS. The patient's excellent clinical outcome demonstrates that combined laparoscopic cholecystectomy and splenectomy is safe, even in patients planning for pregnancy shortly after surgery. This case report has been reported in line with the SCARE Criteria. 3 | Case historyWe report the 5-year follow-up of a 28-year-old Caucasian woman who underwent combined laparoscopic cholecystectomy and splenectomy for severe symptomatic

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confidence: 92%

“…Furthermore, CA 125 has emerged as a tumor marker for lymphoma. A case report of a patient with a history of ovarian cancer specifically linked elevated CA 125 levels to the patient's new follicular lymphoma diagnosis, rather than to ovarian cancer 5 …”

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confidence: 99%

A laparoscopic approach to address massive splenomegaly, symptomatic cholelithiasis, and a planned postoperative pregnancy: A case report

Bishop

Krohn

Vakayil

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

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Waldenström’s macroglobulinemia masquerading as ovarian cancer with peritoneal carcinomatosis, ascites, and elevated CA-125

Eulitt

Fabian

Kelly

et al. 2019

Hematology/Oncology and Stem Cell Therapy

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Waldenström's macroglobulinemia is a rare hematology malignancy which often presents with "B symptoms," anemia, and thrombocytopenia. A 46-year-old woman presented with 2 months of abdominal distension accompanied by an unintentional 20-lb weight loss. Her abdominal CT scan demonstrated diffuse carcinomatosis with bilateral ovarian lesions and screening labs revealed a markedly elevated CA-125, suggesting a diagnosis of ovarian cancer. Upon admission for workup, patient was found to have a significant protein gap, later attributed to a markedly elevated IgM. Omental and bone marrow biopsy confirmed the diagnosis of Waldenström's macroglobulinemia, with elevation in CA-125 thought to be secondary to peritoneal irritation. This patient has since been successfully treated with six cycles of bendamusine and rituximab with no evidence of disease on staging scans and normalization of both CA-125 and IgM. To our knowledge, this is the first documented case of Waldenström's macroglobulinemia presenting with symptoms classically associated with ovarian cancer and demonstrates the importance of maintaining a broad differential when evaluating patients with abdominal carcinomatosis.

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US, CT and MR as Diagnostic Implements in The Detection of Various Primary Malignant Diseases and Ovarian Metatastases Coming from Different Sites of Primary Origin of The Tumor: A Review

2024

JPRD

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Object: We propose a literature review of ultrasound, computer tomography and magnetic resonance in the differention of ovarian lymphoma and metatstatic neoplasm to ovaries correlate with imagies and tables. Methods: Review of the literature. Introduction: Imaging techniques play a fundamental role in the non-invasive evaluation of patients with extranodal lymphoma, both for initial staging and during follow-up and in monitoring the response to treatment. In radiodiagnostics, the means most used in patients with lymphoma are ultrasound, CT, MR and hybrid PET/CT. Dissussion: Unfortunately, in modern literature there are few sources that highlight the major differences that can be detected by ultrasound, CT and MR between the various primary ovarian malignant diseases and ovarian metastases coming from different sites of primary origin of the tumor. In my work I analyze some of them with figures and tables. Conclusion: We would underline that the radiological images of a secondary ovarian neoplasm differ from a ovarian lymphoma based on the nature of the primary disease.

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Elevated Serum CA-125 in a Patient with Follicular Lymphoma and a History of Ovarian Cancer

Cited by 3 publications

References 7 publications

A laparoscopic approach to address massive splenomegaly, symptomatic cholelithiasis, and a planned postoperative pregnancy: A case report

A laparoscopic approach to address massive splenomegaly, symptomatic cholelithiasis, and a planned postoperative pregnancy: A case report

Waldenström’s macroglobulinemia masquerading as ovarian cancer with peritoneal carcinomatosis, ascites, and elevated CA-125

US, CT and MR as Diagnostic Implements in The Detection of Various Primary Malignant Diseases and Ovarian Metatastases Coming from Different Sites of Primary Origin of The Tumor: A Review

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