Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma. Two case reports with immunohistochemical confirmation

Thomas, Joyce; Scriven, M. W.; Puntis, M. C. A.; Jasani, Bharat; Williams, Geraint T.

doi:10.1002/1097-0142(19921001)70:7<1841::aid-cncr2820700706>3.0.co;2-x

Cited by 62 publications

(45 citation statements)

References 7 publications

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“…Hematological and biochemical test results were generally normal but elevated levels of alkaline phosphatase, γ-glutamyl transpeptidase, and bilirubin were found in the cases in which intrahepatic or extrahepatic biliary duct compression was present (three of seven patients). The CEA and CA 19-9 levels in the serum are usually within normal ranges and cannot be considered as significant parameters to discriminate between malignant and benign hepatic tumors [9,10]. However, an elevated serum CA 19-9 level was found in our patient with BCAC, an observation previously reported in few cases of BCA and BCAC [2,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…The CEA and CA 19-9 levels in the serum are usually within normal ranges and cannot be considered as significant parameters to discriminate between malignant and benign hepatic tumors [9,10]. However, an elevated serum CA 19-9 level was found in our patient with BCAC, an observation previously reported in few cases of BCA and BCAC [2,9,10]. On the other hand, consistent with sporadic reports, an elevated CEA levels in tumor fluid, suggesting a biliary origin of the lesion, was found in one patient with BCA [7,10].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma

et al. 2005

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Magnetic resonance imaging (MRI) and magnetic resonance cholangio-pancreatography (MRCP) features were analyzed in the diagnosis of seven surgically resected hepatobiliary cystic tumors with reference to histopathological data. Homogeneity, size, location, signal intensity, presence or absence of septa and/or nodules and MRCP features of the lesions were studied. Histological evidence demonstrated six biliary cystadenoma (BCA) including four pseudo-ovarian stroma (POS) and one biliary cystadenocarcinoma (BCAC). Cystic lesions (3-15 cm in diameter) were homogeneous in the six BCA, heterogeneous in the one BCAC, and were located in the left and right liver, respectively. On T2-weighted images all lesions were hyperintense. On T1-weighted images hypointensity was found in three BCA (all serous fluid, including one POS), isointensity was found in the three others (two mucinous and one hemorrhagic fluid, including three POS) and in the one BCAC (containing mucinous fluid). Septas were present in all cases and nodules only in the one BCAC. On MRCP a hyperintense cystic lesion was found in all cases and a bile ducts dilatation in two BCA and the one BCAC. Gadolinium-enhanced MRI in combination with MRCP is a valuable tool for the diagnosis of BCA or BCAC. However, no specific information is gained for POS detection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma

et al. 2005

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“…The role of MRCP for preoperative imaging still needs to be defined [81] . It is challenging to distinguish the lesions from hepatic cystadenocarcinomas based on current diagnostic studies [82] . Irregular wall enhancement and the presence of papillary projections should increase suspicion for biliary cystadenocarcinoma [83] .…”

Section: Caroli's Diseasementioning

confidence: 99%

Current management of noninfectious hepatic cystic lesions: A review of the literature

Macedo¹

2013

WJH

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Nonparasitic hepatic cysts consist of a heterogeneous group of disorders, which differ in etiology, prevalence, and manifestations. With improving diagnostic techniques, hepatic cysts are becoming more common. Recent advancements in minimally invasive technology created a new Era in the management of hepatic cystic disease. Herein, the most current recommendations for management of noninfectious hepatic cysts are described, thereby discussing differential diagnosis, new therapeutic modalities and outcomes. Key words: simple hepatic cyst; Noninfectious; Polycystic liver disease; Cystadenoma; Cystadenocarcinoma; Caroli's disease; sclerotherapy; Fenestration Core tip: Nonparasitic hepatic cysts consist of a broad spectrum of entities ranging from benign developmental cysts to malignant neoplasms. With recent advancements in diagnostic studies, hepatic cysts are becoming more frequent and better understanding of risk factors, management and long-term outcomes, and further development of current therapeutic modalities are needed.

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“…Few cases of pancreatic cystadenomas with hypercellular, mesenchymal underlying stroma have been reported in the literature [3,7,12,[16][17][18][19], and they are more commonly encountered in the liver and the bile ducts [20]. These lesions occur almost exclusively in women [1,5,11,12,15,17]. Oestrogen receptor expression has been found in some cases [11,13,17,19].…”

Section: Introductionmentioning

confidence: 99%

A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors

et al. 1998

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A 43-year-old man presented with abdominal discomfort caused by relapsing pancreatitis. Radiological examination revealed a multilocular cystic mass in the tail of the pancreas, which was resected. Gross examination showed a multilocular cystic lesion measuring 2.5 cm in diameter and containing clear fluid. Microscopically, a mucinous cystadenoma with mesenchymal stroma was diagnosed. The lesion showed two different components: a cyst lined by a columnar, mucin-secreting epithelium and a moderate cellular stroma composed of spindle cells. The stromal element appeared similar to primitive mesenchyme. Immunohistochemical staining confirmed this origin through vimentin expression and showed moderate to strong nuclear staining with oestrogen and progesterone receptor antibodies. Cystadenomas are rare tumours of the pancreas, but mesenchymal stroma is uncommon in such tumours; it is more frequently described in the liver and the bile ducts, and primarily in women.

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Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma. Two case reports with immunohistochemical confirmation

Cited by 62 publications

References 7 publications

Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma

Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma

Current management of noninfectious hepatic cystic lesions: A review of the literature

A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors

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