Elevated serum cathepsin B concentration in pregnant women is associated with preeclampsia

Kim, Ho Yeon; Kim, Bo Wook; Kim, Yoonjung

doi:10.1007/s00404-016-4129-3

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Circulating concentrations of cathepsin B and D were determined in a cohort of 72 pregnant women in which 25 were preeclamptic and 47 were normotensive. In accordance with our study, cathepsin B concentrations were found to be significantly increased in preeclamptic women, whereas in contrast to our data, no significant difference was found in cathepsin D concentrations between the preeclamptic and control groups, and no correlation was found between the cathepsin concentrations and the severity of preeclampsia (21) . The differential expression or aberrant release of cathepsin proteases from trophoblasts or other types of cells were suggested to have a key role in the pathophysiology of preeclampsia (21) .…”

Section: Discussionsupporting

confidence: 87%

Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia

İlhan

Yıldızhan

2019

tjod

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Objective: The aim of the study was to assess serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia. Materials and Methods: One hundred forty pregnant women were enrolled in the study, of which 100 subjects were preeclamptic and 40 were healthy controls. Serum concentrations of cathepsin B, D, and L were measured and compared between the preeclamptic and control groups. Results: Cathepsin B and D concentrations were significantly higher in the preeclamptic group compared with the control group. There was no statistically significant difference between the groups in terms of cathepsin L concentrations. Cathepsin B concentrations were significantly higher in women with preeclampsia with severe features compared with those with preeclampsia alone. Conclusion: Women with late-onset preeclampsia have significantly higher serum cathepsin B and D concentrations than controls. Cathepsin B and D may be promising biomarkers in women with late-onset preeclampsia.

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Section: Discussionsupporting

confidence: 87%

Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia

İlhan

Yıldızhan

2019

tjod

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“…Another study showed that prolactin fragments with antiangiogenic effects are highly expressed in the placentas of gestational hypertension, whereas the expression of Cat D in the placentas of the gestational hypertension group is significantly decreased [ 33 ]. Kim et al [ 16 , 34 ] found low expression of Cat D in PE serum, and it is believed that insufficient Cat D expression or activity reduces the invasiveness of trophoblast cells. Nakashima et al [ 35 ] also found significantly low expression of Cat D in PE placentas through experiments, and further tests proved that hypoxia can inhibit the expression of Cat D in trophoblast cells.…”

Section: Discussionmentioning

confidence: 99%

Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia

Song,

Zhu,

Pan

et al. 2023

Reprod Biol Endocrinol

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Background Cathepsin C (Cat C) is involved in the inflammatory-immune system and can be degraded by cathepsin D (Cat D). Preeclampsia (PE) and the inflammation-immunity relationship is currently a hot research topic, but there are still few studies. The aim was to investigate the expression and significance of Cat C and D in the serum of nonpregnant women, patients in various stages of pregnancy and patients with PE, and in the placenta of patients with normal pregnancy and PE. Methods Sixty young healthy nonpregnant women were selected: 180 normal pregnant women, including 60 each in the first, second, and third trimesters, and 100 women with PE, including 39 women with severe preeclampsia. The levels of Cat C and D in serum were detected by enzyme-linked immunosorbent assay (ELISA), and the expression levels of Cat C and D in placentas were detected by immunohistochemistry (IHC). Results The serum of Cat C in the first trimester was significantly lower than that in the nonpregnant group (P < 0.001), whereas Cat D was significantly higher than that in the nonpregnant group (P < 0.01). The levels of Cat C and D in the second trimester and third trimester were significantly higher than those in the first trimester (P < 0.05), but there was no significant difference in Cat C and D between the second trimester and third trimester. The levels of Cat C in the serum and placentas of patients with PE were significantly higher than those in the third trimester (P < 0.001) and positively correlated with the severity of PE (P < 0.001), whereas the levels of Cat D in the serum and placentas of patients with PE were significantly lower than those in the third trimester (P < 0.001) and negatively correlated with the severity of PE (P < 0.001). Age, primigravida proportion, and body mass index were significantly higher in the PE group than in the control group (P < 0.05), which were high-risk factors for PE. Conclusions Cat C and D are associated with the maintenance of normal pregnancy. In patients with preeclampsia, a significant increase in Cat C and a significant decrease in Cat D levels may lead to the occurrence and development of preeclampsia.

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Serum sFlt-1, cystatin C and cathepsin B are potential severity markers in preeclampsia: a pilot study

Park

Kim

et al. 2020

Arch Gynecol Obstet

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Elevated serum cathepsin B concentration in pregnant women is associated with preeclampsia

Abstract: The serum levels of cathepsin B levels were increased significantly in preeclamptic women. Correlation with severity of preeclampsia needs further investigation to clarify the role of cathepsin B.

Cited by 6 publications

References 25 publications

Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia

Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia

Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia

Serum sFlt-1, cystatin C and cathepsin B are potential severity markers in preeclampsia: a pilot study

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