Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity

Gooden, Marloes J. M.; Wiersma, Valerie R.; Boerma, Annemarie; Leffers, Ninke; Boezen, H. Marike; Hoor, Klaske A. ten; Hollema, Harmen; Walenkamp, Annemiek; Daemen, Toos; Nijman, Hans W.; Bremer, Edwin

doi:10.1038/bjc.2014.55

Cited by 31 publications

(39 citation statements)

References 38 publications

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“…[20][21][22] But, CXCR6 expression is reported to be not associated with lymphocyte infiltration and survival in ovarian cancer. 23 In the present study, CXCR6 was highly expressed in gastric cancer tissues, and was closely correlated with the lymph node metastases in patients with gastric cancer, indicating that CXCR6 might promote the tumorigenesis of gastric cancer. 24 Metastasis is thought to be the clear mark for many aggressive cancers.…”

Section: Discussionsupporting

confidence: 58%

Blockade of CXCR6 reduces invasive potential of gastric cancer cells through inhibition of AKT signaling

Zhu

et al. 2015

Int J Immunopathol Pharmacol

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Chemokines and their receptors have been implicated in cell migration and metastasis of multiple malignant tumors. But the function of CXCR6 signaling in gastric cancer is not comprehensively understood. In the present study, we hypothesized that CXCR6 signaling might play an essential role in the progression of gastric cancer. The expression of CXCR6 was examined by immunohistochemical assay in human gastric cancer, and lentivirus-mediated CXCR6 knockdown by shRNA (Lv-shCXCR6) was used for investigating cell migration and invasion indicated by Wound-healing and Transwell assays. Consequently, the expression level of CXCR6 was increased in gastric cancer compared with the adjacent non-tumor tissues (54.2% vs. 27.1%, P = 0.006), and was closely associated with the metastatic lymph node in gastric cancer (P = 0.021). Furthermore, blockade of the CXCR6 signaling reduced the migration and invasion of gastric cancer cells followed by decreased expression of AKT, MMP-2, and MMP-9. In conclusion, these findings demonstrate that CXCR6 may promote the development of gastric cancer cells through regulation of AKT signaling.

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Section: Discussionsupporting

confidence: 58%

Blockade of CXCR6 reduces invasive potential of gastric cancer cells through inhibition of AKT signaling

Zhu

et al. 2015

Int J Immunopathol Pharmacol

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“…ADAM‐mediated substrate shedding has prognostic potential for ovarian cancer. Soluble CXCL16/CXCR6, in pretreatment serum samples, has been reported to independently predict poor survival for cancer patients (Gooden et al, ), and may therefore serve as a marker that identifies patients with highly metastatic tumors (Gooden et al, ). ADAM17 is a sheddase for activated leukocyte cell adhesion molecule and soluble activated leukocyte cell adhesion molecule [sALCAM] levels were found to be significantly higher in the serum of EOC patients ( P < 0.005) compared to that of healthy controls and correlated with more aggressive Type II tumors (Carbotti et al, ).…”

Section: Diagnosis and Prognosis Of Cancers By Mmpsmentioning

confidence: 99%

Metalloproteinases and their roles in human cancer

Roy

Morad

Jedinak

et al. 2019

The Anatomical Record

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It is now widely appreciated that members of the matrix metalloproteinase (MMP) family of enzymes play a key role in cancer development and progression along with many of the hallmarks associated with them. The activity of these enzymes has been directly implicated in extracellular matrix remodeling, the processing of growth factors and receptors, the modulation of cell migration, proliferation, and invasion, the epithelial to mesenchymal transition, the regulation of immune responses, and the control of angiogenesis. Certain MMP family members have been validated as biomarkers of a variety of human cancers including those of the breast, brain, pancreas, prostate, ovary, and others. The related metalloproteinases, the A disintegrin and metalloproteinases (ADAMs), share a number of these functions as well. Here, we explore these essential metalloproteinases and some of their disease-associated activities in detail as well as some of their complementary translational potential. Anat Rec, 303:1557-1572, 2020.Matrix metalloproteinases (MMPs) are a multigene family of metal-dependent endopeptidases that play important and diverse roles in normal physiological and pathological processes. The classic domain structure of MMP family members can be found in Figure 1 (Roy et al., 2009). MMPs include an amino-terminal signal peptide required for secretion, a pro-domain that mediates latency via a cysteine-switch mechanism and a Zn 2+ -dependent catalytic domain that is responsible for enzymatic function. A majority of MMPs also contain a C-terminal hemopexinlike domain that provides substrate specificity. MMP activity is the rate-limiting step in extracellular matrix (ECM) degradation and it can regulate the activity of other proteases, growth factors, cytokines, and cell-surface ligands

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“…SR-PSOX/CXCL16 and its binding partner CXCR6, as well as its processing enzyme ADAM10 and ADAM17, are overexpressed in many tumor cells, including prostate, breast, colorectal, gastric, liver, ovarian, pancreatic, cervical, lung cancer, glial tumors, and Ewing sarcoma (Gooden et al, 2014; Hattermann, Held-Feindt, Ludwig, & Mentlein, 2013; Huang, Zhang, Cui, Zhao, & Zheng, 2013; Na et al, 2014; Wente et al, 2008). Increasing evidence supports the involvement of sCXCL16 in tumor progression, e.g., promoting proliferation, migration, and invasiveness of CXCR6 + cancer cells (Lu et al, 2008; Schramme et al, 2008; Xing et al, 2012).…”

Section: Scavenger Receptors In Cancer Immunobiologymentioning

confidence: 99%

“…Increasing evidence supports the involvement of sCXCL16 in tumor progression, e.g., promoting proliferation, migration, and invasiveness of CXCR6 + cancer cells (Lu et al, 2008; Schramme et al, 2008; Xing et al, 2012). The elevated level of sCXCL16 in serum has been considered an independent predictor for poor survival in ovarian cancer patients and those with colorectal cancer who have developed the recurrence of liver metastases (Gooden et al, 2014; Matsushita et al, 2012). Independent studies also support the association of SR-PSOX/CXCL16 with poor prognosis in various cancers.…”

Section: Scavenger Receptors In Cancer Immunobiologymentioning

confidence: 99%

Scavenger Receptors

Guo

Fisher

et al. 2015

Advances in Cancer Research

101

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Scavenger receptors constitute a large family of evolutionally conserved protein molecules that are structurally and functionally diverse. Although scavenger receptors were originally identified based on their capacity to scavenge modified lipoproteins, these molecules have been shown to recognize and bind to a broad spectrum of ligands, including modified and unmodified host-derived molecules or microbial components. As a major subset of innate pattern recognition receptors, scavenger receptors are mainly expressed on myeloid cells and function in a wide range of biological processes, such as endocytosis, adhesion, lipid transport, antigen presentation, and pathogen clearance. In addition to playing a crucial role in maintenance of host homeostasis, scavenger receptors have been implicated in the pathogenesis of a number of diseases, e.g., atherosclerosis, neurodegeneration, or metabolic disorders. Emerging evidence has begun to reveal these receptor molecules as important regulators of tumor behavior and host immune responses to cancer. This review summarizes our current understanding on the newly identified, distinct functions of scavenger receptors in cancer biology and immunology. The potential of scavenger receptors as diagnostic biomarkers and novel targets for therapeutic interventions to treat malignancies is also highlighted.

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Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity

Cited by 31 publications

References 38 publications

Blockade of CXCR6 reduces invasive potential of gastric cancer cells through inhibition of AKT signaling

Blockade of CXCR6 reduces invasive potential of gastric cancer cells through inhibition of AKT signaling

Metalloproteinases and their roles in human cancer

Scavenger Receptors

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