Elevated Serum Iron Is a Potent Biomarker for Spirometric Resistance to Cigarette Smoke among Japanese Males: The Takahata Study

Shibata, Yoko; Inoue, Sumito; Igarashi, Akira; Yamauchi, Keiko; Abe, Shuichi; Aida, Yasuko; Nunomiya, Keiko; Sato, Masamichi; Nakano, Hiroshi; Sato, Kento; Watanabe, Tetsu; Konta, Tuneo; Ueno, Yoshiyuki; Kato, Takeshi; Kayama, Takamasa

doi:10.1371/journal.pone.0074020

Cited by 25 publications

(14 citation statements)

References 22 publications

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“…This is comparable to prior investigation which demonstrated that serum ferritin concentration negatively correlated with the FEV 1 /FVC ratio reflecting a positive association of the metal storage protein with airway obstruction 19. Studies have also demonstrated that FVC and FEV 1 can correlate positively with serum ferritin and iron concentrations and transferrin saturation 20–22. The disruption in iron homeostasis with cigarette smoking can be associated with oxidative stress, and this can initiate pathways resulting in COPD.…”

Section: Discussionsupporting

confidence: 84%

Indices of iron homeostasis correlate with airway obstruction in an NHANES III cohort

Ghio¹,

Hilborn²

2017

COPD

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Cigarette smoking results in the accumulation of iron both systemically and locally, in the lung thereby causing imbalance in iron homeostasis. This disruption in iron homeostasis can be associated with oxidative stress and consequent tissue injury. Therefore, in this study, we tested the association between iron homeostasis and airway obstruction by examining a large cohort of smokers and non-smokers for relationships between 1) serum ferritin and iron concentrations and transferrin saturation and 2) forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and their ratio (FEV1/FVC). Data from the National Health and Examination Survey III were analyzed. The study population included persons aged 20 years and above with their following data recorded: race, gender, serum ferritin and iron concentrations, and transferrin saturation; the final sample number was 7,251. In the total population, Pearson correlation coefficients between 1) serum ferritin and iron concentrations and transferrin saturation and 2) FVC and FEV1 were significantly positive; whereas those between 1) serum ferritin concentrations and transferrin saturation and 2) FEV1/FVC were significantly negative. With separate analyses, serum ferritin concentrations demonstrated positive associations with FVC and FEV1 but an inverse relationship with FEV1/FVC in smokers and non-smokers. Serum ferritin levels increased with worsening airway obstruction among smokers, and its highest concentrations were found among those with the lowest values of FEV1/FVC ratio (<60%). Comparable to cigarette smokers, serum ferritin concentrations among non-smokers were greatest in those with the lowest FEV1/FVC ratio. Furthermore, elevated levels of serum iron and saturation of transferrin also corresponded with decreased FEV1/FVC ratio among non-smokers. Thus, we conclude that indices of iron homeostasis are associated with airway obstruction in both smokers and non-smokers.

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Section: Discussionsupporting

confidence: 84%

Indices of iron homeostasis correlate with airway obstruction in an NHANES III cohort

Ghio¹,

Hilborn²

2017

COPD

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“…As a potential biological mechanism, it has been suggested that smoking may stimulate erythropoiesis in a dose-related manner due to hypoxia, which is induced by smoking. In addition, hypoxia is likely to suppress hepcidin expression [8919202122]. …”

Section: Discussionmentioning

confidence: 99%

Associations between Lifestyle Factors and Iron Overload in Korean Adults

2016

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It has been suggested that iron overload, which indicates the accumulation of iron, generates cellular reactive oxygens and causes peroxide damages to the body. Such oxidative stresses, in a broader context, are also caused by lifestyles such as alcohol consumption and smoking. However, there are limited data on the association between these lifestyle factors and internal iron overload. In present study, we evaluated associations between lifestyle factors, such as smoking status, alcohol consumption, and physical activity, and serum markers of iron overload. In a population-based cross-sectional study including 2,347 Korean men and women aged 49–79 years, we assessed serum transferrin saturation (TSAT) levels and defined iron overload as TSAT levels > 50% for men and > 45% for women. After excluding persons with chronic diseases and iron deficiency, multivariate odds ratio (OR) and its 95% confidence interval (CI) were estimated to evaluate associations between lifestyle factors and iron overload in 1,973 participants. In all participants, we examined a significantly positive association between heavy alcohol consumption (> 30 g/day) and iron overload; heavy drinkers showed 1.6-fold higher OR (95% CI, 1.11–2.36) than non-drinkers. Stratified analysis by sex showed that this association was significant only among men. In addition, we observed a potential association between heavy smoking > 10 cigarettes/day and iron overload (p = 0.07). In stratified analysis by sex, we examined a significant association between smoking and iron overload only among women; former or current smokers had 1.9-fold higher OR (95% CI, 1.01–3.63) than never-smoker. Our findings suggest that heavy alcohol consumption and smoking may worsen iron accumulation in the body.

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“…Previously, we demonstrated that hyperhomocysteinemia and lower serum iron levels were predictive of a rapid decline in FEV 1 in men who were continuing smokers using the Takahata Study database between 2004-2006 (Visit 1) and 2009 (Visit 2) (n = 147) 16, 19. In 2011 (Visit 3), we re-performed the pulmonary function measurements for 873 participants in this study.…”

Section: Discussionmentioning

confidence: 99%

Association between Plasma Adiponectin Levels and Decline in Forced Expiratory Volume in 1 s in a General Japanese Population: The Takahata Study

Sato¹,

Shibata²,

Abe³

et al. 2014

Int. J. Med. Sci.

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Background:Adiponectin is an anti-inflammatory and cardio-protective cytokine. However, several studies have demonstrated that plasma adiponectin levels were inversely associated with pulmonary function in patients with chronic obstructive pulmonary disease, suggesting a proinflammatory or pulmonary-destructive role. It is still unclear whether adiponectin is a potent biomarker predicting declines in pulmonary function. The aim of this study was to investigate the association between adiponectin and pulmonary function among Japanese individuals who participated in an annual health check-up.Methods:Spirometry and blood sampling, including measurements of plasma adiponectin, were performed for 3,253 subjects aged 40 years or older who participated in a community-based annual health check-up in Takahata, Japan from 2004 to 2006. In 2011, spirometry was re-performed, and the data from 872 subjects (405 men and 467 women) were available for a longitudinal analysis.Results:Plasma adiponectin levels were found to be significantly associated with age, body mass index (BMI), and alanine aminotransferase (ALT), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-c) levels among both men and women in the study population. Plasma adiponectin levels were found to be associated with lifetime cigarette consumption (Brinkman index, BI) in men only. Plasma adiponectin levels were inversely correlated with forced expiratory volume in 1 s (FEV1) per forced vital capacity in both men and women. In addition, the annual change in FEV1 was inversely associated with plasma adiponectin levels in both genders. A multiple linear regression analysis revealed that this association was independent of other confounding factors such as age, BMI, BI, ALT, TG, and HDL-c.Conclusions:The results of the present study suggest that adiponectin levels are predictive of declines in FEV1 in the general population.

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Elevated Serum Iron Is a Potent Biomarker for Spirometric Resistance to Cigarette Smoke among Japanese Males: The Takahata Study

Cited by 25 publications

References 22 publications

Indices of iron homeostasis correlate with airway obstruction in an NHANES III cohort

Indices of iron homeostasis correlate with airway obstruction in an NHANES III cohort

Associations between Lifestyle Factors and Iron Overload in Korean Adults

Association between Plasma Adiponectin Levels and Decline in Forced Expiratory Volume in 1 s in a General Japanese Population: The Takahata Study

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