Elevated Serum Level and Altered Glycosylation of α1-Acid Glycoprotein in Hyperimmunoglobulinemia D and Periodic Fever Syndrome: Evidence for Persistent Inflammation

Havenaar, Ellen C.; Drenth, J.P.H.; Ommen, E. C. R. Van; Meer, J.W.M. van der; Dijk, W. van

doi:10.1006/clin.1995.1126

Cited by 26 publications

(12 citation statements)

References 8 publications

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“…1a). This response is similar to that described in patients with familial Mediterranean fever (FMF), although generally the acute phase response is more intense and more prolonged than in FMF [18–21].…”

Section: Discussionsupporting

confidence: 76%

Effect of inflammatory attacks in the classical type hyper‐IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response

Simon

Bijzet²,

Voorbij

et al. 2004

Journal of Internal Medicine

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Section: Discussionsupporting

confidence: 76%

Effect of inflammatory attacks in the classical type hyper‐IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response

Simon

Bijzet²,

Voorbij

et al. 2004

Journal of Internal Medicine

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“…A significant increase of glycan-containing glycoforms of AGP occurs during the hyperimmunoglobulinemia D and periodic fever syndrome: the increase of (1-3)-linked fucosylation, accompanied by a high expression of sLe X , and an higher concentration of CRP, contributed to indicating this syndrome as an inflammatory disease [140]. A modification of the fucosylation status of AGP is also observed in liver cirrhosis, where an increase of fucose residues on the surface of the protein has been detected in ascitic fluid [141].…”

Section: Glycan Pattern Modification Of Agp During Diseasementioning

confidence: 99%

The Acute Phase Protein α1-Acid Glycoprotein: A Model for Altered Glycosylation During Diseases

Ceciliani¹,

Pocacqua²

2007

CPPS

194

200

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Glycosylation is one of the most important post-translational modifications of proteins, and has been widely acknowledged as one of the most important ways to modulate both protein function and lifespan. The acute phase proteins are a major group of serum proteins whose concentration is altered during various pathophysiological conditions. The aim of this paper is to review the structure and functions of the alpha1-acid glycoprotein (AGP). AGP belongs to the subfamily of immunocalins, a group of binding proteins that also have immunomodulatory functions. One of the most interesting features of AGP is that its glycosylation microheterogeneity can be modified during diseases. This aspect is particularly remarkable, since both the immunomodulatory and the binding properties of AGP strongly depend on its carbohydrate composition. For these reasons, AGP can be considered an outstanding model for the study of glycan pattern modification during diseases. This review is focused on the most recent studies on the occurrence of different glycoforms in plasma and tissues and how the appearance of different oligosaccharide patterns during systemic inflammation or diseases can influence AGP's biological functions. The first part of the review will describe the structure of AGP and the several biological functions identified so far for this protein. The second part will be devoted to the post-translational modifications of the oligosaccharides micro-heterogeneity of AGP caused by pathological states. A critical evaluation of the impact of different AGP glycoforms on both its transport and anti-inflammatory features, and how the modifications of the glycan pattern can be utilized in clinical biochemistry, is also discussed.

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“…6,7 Inflammatory cytokines such as interleukin1b (IL-1b), IL-6 and tumour necrosis factor-a (TNF-a) are thought to play a central role in multiple effector functions and cellular interactions in inflammation and immune response. 8 Uncontrolled secretion leading to high levels of inflammatory cytokines may lead to an intense inflammatory response as noted in the HIDS.…”

Section: Introductionmentioning

confidence: 99%

“…The attacks are accompanied by an acute phase response with high circulating concentrations of a 1 -acid glycoprotein (AGP), Creactive protein (CRP), soluble type II phospholipase A 2 and serum amyloid A. 6,7 Inflammatory cytokines such as interleukin-1b (IL-1b), IL-6 and tumour necrosis factor-a (TNF-a) are thought to play a central role in multiple effector functions and cellular interactions in inflammation and immune response. 8 Uncontrolled secretion leading to high levels of inflammatory cytokines may lead to an intense inflammatory response as noted in the HIDS.…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin D enhances the release of tumour necrosis factor‐α, and interleukin‐1β as well as interleukin‐1 receptor antagonist from human mononuclear cells

et al. 1996

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SUMMARYImmunoglobulin D (IgD) is normally present in only low concentrations in serum. In the hyper-IgD and periodic fever syndrome (HIDS), however, serum levels exceed 140 mg/l. This syndrome is further characterized by recurrent inflammatory febrile attacks together with an acute phase response and appearance of cytokines in the circulation. The role of IgD in the pathogenesis of HIDS and its relation to the increased cytokine concentrations is unclear. Therefore, we tested whether IgD, IgG and a 1 -acid glycoprotein (AGP) isolated from human serum influence the synthesis of interleukin-1b (IL-1b), tumour necrosis factor-a (TNF-a), and IL-1ra, as measured by specific radioimmunoassays, in human peripheral blood mononuclear cells (PBMC). Incubation of PBMC with IgD and AGP for 24 hr led to increased release of IL-1b, TNF-a, and IL-1ra. The magnitude of stimulation of IgD exceeded that of AGP; the effect by IgD was dose-dependent and showed a 30-fold (TNF-a) to almost 150-fold (IL-1b) increase at the highest concentration (50 mg/l), while AGP (750 m g/ml) only increased the cytokine secretion fourfold (TNF-a) to almost 30-fold (IL-1b). The effect of IgD on IL-1ra was less dramatic but a fivefold increase was observed at 50 mg/l compared with a 2 . 5-fold increase with AGP. IgD potentiated the effect of lipopolysaccharide (LPS) on secretion of both IL-1b and TNF-a, although the effect was most apparent for TNF-a. Apart from inducing IL-1ra synthesis, IgG did not influence cytokine release in human PBMC. These data indicate that IgD is a potent inducer of TNF-a, IL-1b and IL-1ra and thus may contribute to the pathogenesis of HIDS.

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Elevated Serum Level and Altered Glycosylation of α1-Acid Glycoprotein in Hyperimmunoglobulinemia D and Periodic Fever Syndrome: Evidence for Persistent Inflammation

Cited by 26 publications

References 8 publications

Effect of inflammatory attacks in the classical type hyper‐IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response

Effect of inflammatory attacks in the classical type hyper‐IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response

The Acute Phase Protein α1-Acid Glycoprotein: A Model for Altered Glycosylation During Diseases

Immunoglobulin D enhances the release of tumour necrosis factor‐α, and interleukin‐1β as well as interleukin‐1 receptor antagonist from human mononuclear cells

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Elevated Serum Level and Altered Glycosylation of α1-Acid Glycoprotein in Hyperimmunoglobulinemia D and Periodic Fever Syndrome: Evidence for Persistent Inflammation

Cited by 26 publications

References 8 publications

Effect of inflammatory attacks in the classical type hyper‐IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response

Effect of inflammatory attacks in the classical type hyper‐IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response

The Acute Phase Protein &#945;1-Acid Glycoprotein: A Model for Altered Glycosylation During Diseases

Immunoglobulin D enhances the release of tumour necrosis factor‐α, and interleukin‐1β as well as interleukin‐1 receptor antagonist from human mononuclear cells

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The Acute Phase Protein α1-Acid Glycoprotein: A Model for Altered Glycosylation During Diseases