Elevated serum substance P level as a predictive marker for moderately emetogenic chemotherapy‐induced nausea and vomiting: A prospective cohort study

Park, Hyung Soon; Won, Hye Sung; An, Ho Jung; Cho, Sung Shim; Kim, Hyun Ho; Sun, Der Sheng; Ko, Yoon Ho; Shim, Byoung Yong

doi:10.1002/cam4.3693

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…A similar biophysiologic marker exists in substance p, a neurotransmitter implicated in delayed CIN. Recent literature has suggested serum substance p may be a predictive marker for CIN (Park et al, 2020), and this measure may allow research on music listening the option of another biophysiologic outcome variable to corroborate with patient’s self-report data.…”

Section: Discussionmentioning

confidence: 92%

Mitigation of Chemotherapy-Induced Nausea Using Adjunct Music Listening: A Pilot Study

Kiernan

Vallerand

2023

Clin Nurs Res

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The persistence of chemotherapy-induced nausea (CIN) underscores the need to consider nonpharmacologic treatments such as music listening as adjunct interventions. This pilot study investigated the feasibility and overall effects of a 30-minute adjunct music listening intervention in 12 patients experiencing CIN. Music listening was started at the time participants took their as-needed antiemetic medication, and it was repeated as needed during the 5 days after chemotherapy. Data for 66 music listening engagements were collected. A significant reduction of nausea severity ( t = 10.97, p < .001) and distress ( t = 9.86, p < .001) was noted overall, as well as significant reductions when examining the acute and delayed phases of nausea individually. Qualitative data on study feasibility demonstrated the intervention was well received by participants and held minimal operational difficulty. Investigator feasibility data suggested good understanding of data collection tools. Improvements to the study design have been collected and will form the basis of the future randomized controlled trial.

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Section: Discussionmentioning

confidence: 92%

Mitigation of Chemotherapy-Induced Nausea Using Adjunct Music Listening: A Pilot Study

Kiernan

Vallerand

2023

Clin Nurs Res

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“… 32 , 33 Further, a limited number of biomarkers associated with CINV have been investigated previously. 34 In the current study, we explored the correlation between substance P and 5-HT, and their relationship with the prognosis of CINV in a subset of patients with baseline blood samples. Baseline plasma concentration of 5-HT was found to be another risk factor associated with complete response in addition to clinical risk factors.…”

Section: Discussionmentioning

confidence: 99%

A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of olanzapine plus triple antiemetic regimen for the prevention of multiday highly emetogenic chemotherapy-induced nausea and vomiting (OFFER study)

et al. 2023

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“…However, the evidence for this possibility in response to emetic stimuli is weak. Thus, in patients undergoing chemotherapy, the elevation of serum concentrations of SP during the delayed phase of vomiting was inconsistent [128][129][130][131][132] although this is the phase during which NK 1 RA are most effective (see above).…”

Section: Area Postremamentioning

confidence: 99%

An assessment of the effects of neurokinin₁receptor antagonism against nausea and vomiting: Relative efficacy, sites of action and lessons for future drug development

Andrews

Golding

Sanger

2023

Brit J Clinical Pharma

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A ‘broad‐spectrum’ anti‐vomiting effect of neurokinin1 receptor antagonists (NK1RA), shown in preclinical animal studies, has been supported by a more limited range of clinical studies in different indications. However, this review suggests that compared with vomiting, the self‐reported sensation of nausea is less affected or possibly unaffected (depending on the stimulus) by NK1 receptor antagonism, a common finding for ‘anti‐emetics’.The stimulus‐independent effects of NK1RAs against vomiting are explicable by actions within the central pattern generator (CPG; ventral brainstem) and the nucleus tractus solitarius (NTS; dorsal brainstem), with additional effects on vagal afferent activity for certain stimuli (e.g., highly emetogenic chemotherapy). The CPG and NTS neurones are multifunctional so the notable lack of obvious effects of NK1RAs on other reflexes mediated by the same neurones suggests that their anti‐vomiting action is dependent on the activation state of the pathway leading to vomiting.Nausea requires activation of cerebral pathways by projection of information from the NTS. Although NK1 receptors are present in cerebral nuclei implicated in nausea, and imaging studies show very high receptor occupancy at clinically used doses, the variable or limited ability of NK1RAs to inhibit nausea emphasises (a) our inadequate understanding of the mechanisms of nausea and (b) that classification of a drug as an “anti‐emetic” may give a false impression of efficacy against nausea versus vomiting.We discuss the potential mechanisms for the differential efficacy of NK1RA and the implications for future development of drugs which can effectively treat nausea, an area of unmet clinical need.

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Elevated serum substance P level as a predictive marker for moderately emetogenic chemotherapy‐induced nausea and vomiting: A prospective cohort study

Cited by 8 publications

References 25 publications

Mitigation of Chemotherapy-Induced Nausea Using Adjunct Music Listening: A Pilot Study

Mitigation of Chemotherapy-Induced Nausea Using Adjunct Music Listening: A Pilot Study

A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of olanzapine plus triple antiemetic regimen for the prevention of multiday highly emetogenic chemotherapy-induced nausea and vomiting (OFFER study)

An assessment of the effects of neurokinin₁receptor antagonism against nausea and vomiting: Relative efficacy, sites of action and lessons for future drug development

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Elevated serum substance P level as a predictive marker for moderately emetogenic chemotherapy‐induced nausea and vomiting: A prospective cohort study

Cited by 8 publications

References 25 publications

Mitigation of Chemotherapy-Induced Nausea Using Adjunct Music Listening: A Pilot Study

Mitigation of Chemotherapy-Induced Nausea Using Adjunct Music Listening: A Pilot Study

A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of olanzapine plus triple antiemetic regimen for the prevention of multiday highly emetogenic chemotherapy-induced nausea and vomiting (OFFER study)

An assessment of the effects of neurokinin1receptor antagonism against nausea and vomiting: Relative efficacy, sites of action and lessons for future drug development

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An assessment of the effects of neurokinin₁receptor antagonism against nausea and vomiting: Relative efficacy, sites of action and lessons for future drug development