Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM

Xu, Jingwu; Ahmad, Ali; Jones, James F.; Dolcetti, Riccardo; Vaccher, Emanuela; Prasad, U.; Menezes, José

doi:10.1128/jvi.74.5.2443-2446.2000

Cited by 37 publications

(30 citation statements)

References 31 publications

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“…6). The concentrations of circulating latent TGF-␤1 protein were consistent with values found in studies of infection with Epstein-Barr virus in humans; however, the quantity of circulating active TGF-␤1 protein was approximately 100-fold lower than that found in the same study (23) and was probably not biologically significant. Also, there was no significant difference among the quantities of active TGF-␤1 in the sera of the infected calves at each time point studied (t test, P Ͼ 0.05).…”

Section: Ncpbvdv Stimulates Ifn-␥ Responses In Vivosupporting

confidence: 74%

Alpha/Beta and Gamma Interferons Are Induced by Infection with Noncytopathic Bovine Viral Diarrhea Virus In Vivo

Charleston

Brackenbury

Carr

et al. 2002

J Virol

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In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor ␤ (TGF-␤) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-␤.

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Section: Ncpbvdv Stimulates Ifn-␥ Responses In Vivosupporting

confidence: 74%

Alpha/Beta and Gamma Interferons Are Induced by Infection with Noncytopathic Bovine Viral Diarrhea Virus In Vivo

Charleston

Brackenbury

Carr

et al. 2002

J Virol

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“…The role of immunosuppressive effect of TGF-h in cancer progression has been well established (13,(25)(26)(27). In the present study, we have shown that, TRAMP-C2 tumors possess potent immunosuppressive power so that regular CD8 + T cells are unable to infiltrate into the tumor tissues.…”

Section: Discussionmentioning

confidence: 53%

Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-β–Insensitive CD8+ T Cells: Eradication of Autologous Mouse Prostate Cancer

Zhang¹,

Yang²,

Pins³

et al. 2005

Cancer Research

138

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Transforming growth factor (TGF)-B is a potent immunosuppressant. Overproduction of TGF-B by tumor cells may lead to tumor evasion from the host immune surveillance and tumor progression. The present study was conducted to develop a treatment strategy through adoptive transfer of tumor-reactive TGF-B-insensitive CD8 + + T cells. The mouse TRAMP-C2 prostate cancer cells produced large amounts of TGF-B1 and were used as an experimental model. C57BL/6 mice were primed with irradiated TRAMP-C2 cells. CD8 + + T cells were isolated from the spleen of primed animals, were expanded ex vivo, and were rendered TGF-B insensitive by infecting with a retrovirus containing dominant-negative TGF-B type II receptor. Results of in vitro cytotoxic assay revealed that these CD8 + T cells showed a specific and robust tumor-killing activity against TRAMP-C2 cells but were ineffective against an irrelevant tumor line, B16-F10. To determine the in vivo antitumor activity, recipient mice were challenged with a single injection of TRAMP-C2 cells for a period up to 21 days before adoptive transfer of CD8 + + T cells was done. Pulmonary metastasis was either eliminated or significantly reduced in the group receiving adoptive transfer of tumor-reactive TGF-B-insensitive CD8 + + T cells. Results of immunofluorescent studies showed that only tumor-reactive TGF-B-insensitive CD8 + + T cells were able to infiltrate into the tumor and mediate apoptosis in tumor cells. Furthermore, transferred tumor-reactive TGF-B-insensitive CD8 + + T cells were able to persist in tumor-bearing hosts but declined in tumor-free animals. These results suggest that adoptive transfer of tumor-reactive TGF-B-insensitive CD8 + + T cells may warrant consideration for cancer therapy.

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“…TGF-β in neurons has also been reported in mice with experimental allergic encephalomyelitis (Fujinami, 2006;Issazadeh et al, 1998) and in rats with spinal cord injury (O'Brien et al, 1994). Although in vivo induction of TGF-β1 specifically in CNS neurons by virus infections has not been reported, TGF-β1 is produced or activated in other cell types by several virus infections [reviewed in (Fitzpatrick and Bielefeldt-Ohmann, 1999)], including Epstein-Barr virus (Xu et al, 2000), cytomegalovirus (Haagmans et al, 1997;Michelson et al, 1994), herpes simplex virus (Méndez-Samperio et al, 2000), human T-lymphotropic virus (HTLV)-I, human immunodeficiency virus (HIV) (Lotz and Seth, 1993;Wahl et al, 1991;Yamamoto et al, 1999), influenza virus (Schultz-Cherry andHinshaw, 1996) and yellow fever virus (Quaresma et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

TGF-β1 suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler's virus

Tsunoda

Libbey

Fujinami

2007

Journal of Neuroimmunology

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GDVII and DA strains of Theiler's murine encephalomyelitis virus (TMEV) differ in VP2 puff B. One week after GDVII virus infection, SJL/J mice had large numbers of TUNEL + apoptotic cells with a relative lack of T cell infiltration in the brain. DA viruses with mutation in puff B induced higher levels of apoptosis than wild-type DA virus, but levels of inflammation in brains were similar between DA and DA virus mutants. The difference in inflammation among TMEVs could be due to TGF-β1 expression that was seen only in GDVII virus infection and negatively correlated with CD3 + T cell infiltration.

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Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM

Cited by 37 publications

References 31 publications

Alpha/Beta and Gamma Interferons Are Induced by Infection with Noncytopathic Bovine Viral Diarrhea Virus In Vivo

Alpha/Beta and Gamma Interferons Are Induced by Infection with Noncytopathic Bovine Viral Diarrhea Virus In Vivo

Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-β–Insensitive CD8+ T Cells: Eradication of Autologous Mouse Prostate Cancer

TGF-β1 suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler's virus

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