2013
DOI: 10.1016/j.metabol.2012.08.013
|View full text |Cite
|
Sign up to set email alerts
|

Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey

Abstract: Objective Experimental and observational studies suggest a role for uric acid in non-alcoholic fatty liver disease (NAFLD). We examined the association between serum uric acid levels and NAFLD in a large population-based study from the United States. Materials/Methods A cross-sectional analysis of 10,732 nondiabetic adults who participated in the National Health and Nutrition Examination Survey 1988–1994. Sex specific uric acid quartiles were defined: ≤5.2, 5.3–6.0, 6.1–6.9, and >6.9 mg/dL for men and ≤3.7, … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

12
106
1
7

Year Published

2013
2013
2022
2022

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 151 publications
(126 citation statements)
references
References 45 publications
12
106
1
7
Order By: Relevance
“…11,12 Recent experimental studies have reported a benefit of hypouricemic therapy in ameliorating fat deposition in liver, [13][14][15] suggesting an etiological contribution of uric acid in the development of NAFLD or metabolic syndrome. In this study, we have demonstrated uric acidinduced fat accumulation in hepatocytes by enhancing the expression of lipogenic enzymes, which was associated with ER stress-mediated SREBP-1c cleavage and nuclear translocation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…11,12 Recent experimental studies have reported a benefit of hypouricemic therapy in ameliorating fat deposition in liver, [13][14][15] suggesting an etiological contribution of uric acid in the development of NAFLD or metabolic syndrome. In this study, we have demonstrated uric acidinduced fat accumulation in hepatocytes by enhancing the expression of lipogenic enzymes, which was associated with ER stress-mediated SREBP-1c cleavage and nuclear translocation.…”
Section: Discussionmentioning
confidence: 99%
“…9,10 A recent epidemiological study using data from the National Health and Nutrition Examination Survey revealed that uric acid was associated with NAFLD independently of metabolic syndrome. 11 Additional studies have shown that elevated serum uric acid is an independent predictor of NAFLD. 12 Recently, uric acid has been shown to have direct effects to increase hepatic fat accumulation via a mechanism involving the induction of mitochondrial oxidative stress, 13 and lowering uric acid has been found to block hepatic fat accumulation in a variety of animal models.…”
mentioning
confidence: 99%
“…Previous studies have shown a close association between UA production and non-alcoholic fatty liver disease (Li et al, 2009;Sirota et al, 2013), liver cancer (Port et al, 2014), and other liver diseases. Hepatocytes are the primary sites of UA generation.…”
Section: Introductionmentioning
confidence: 94%
“…Nevertheless, an increasing body of evidence highlights the role of uric acid in diseases such as chronic kidney disease (11), fatty liver disease (12), cardiorenal syndrome and hypertension (13,14), coronary heart disease (15,16), type 2 diabetes (17), aging (18), and cancer (19), in addition to gout. The many associations of uric acid with common inflammatory diseases lead to a scenario of thrifty genes that currently predispose to fat storage disorders and systemic comorbidities (20).…”
mentioning
confidence: 99%