Elevated serum uric acid predicts impaired fasting glucose and type 2 diabetes only among Japanese women undergoing health checkups

The Association Between Serum Uric Acid and Diabetes Mellitus Is Stronger in Women

“…Several population-based cohorts have also demonstrated a greater association between uric acid and diabetes incidence in women than in men, [15][16][17] albeit sometimes with no statistical significance 15 or without including in the multivariate model several significant confounders that may influence uric acid levels, such as chronic use of diuretics and serum creatinine, [15][16][17] both included in our study, or with an analysis of a composite outcome that includes both impaired fasting glucose and diabetes conditions rather than diabetes alone, 17 as in our study.…”

“…7,14 Additionally, most studies have focused on male populations with substantial cardiovascular risk factors or have not analyzed males and females separately. Although some evidence suggests that the risk for diabetes in the context of elevated uric acid may be more pronounced in women, 12,[15][16][17] other studies did not find a significant interaction by gender between uric acid and diabetes. 11,14 In this relatively large retrospective cohort analysis, we aimed to investigate the hypothesis that uric acid is associated with the development of diabetes in an ambulatory adult population of apparently healthy men and women.…”

Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways

“…Moreover, hyperuricaemia is strongly involved in insulin resistance and abnormal glucose metabolism [9]. In terms of pancreatic β-cells are the producers of insulin, thus the abnormal insulin secretion under glucose stimulation might be a common damage induced by uric acid.…”

“…Hyperuricaemia strongly correlates with insulin resistance and abnormal glucose metabolism [9]. Pancreatic β-cells participate in glucose metabolism and exert critical core roles.…”

“…Long term of high uric acid can lead to multiple organ involvement and tissue loss, such as arthritis, gout, kidney disease and cardiovascular disease. In addition, high uric acid content can also damage beta islet cells, reduce the sensitivity to insulin, resulting in the high incidence of diabetes mellitus type 2 [4][5][6][7][8][9]. As of now, the treatment of hyperuricemia mainly focuses on drugs, such as probenecid, sulfinpyrazone, benzbromarone, allopurinol and xanthine oxidase inhibitor (XOI).…”