Elevated sister chromatid exchange frequencies in New Zealand Vietnam War veterans

Rowland, R.E.; Edwards, Lilian; Podd, John

doi:10.1159/000100407

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…Ex-airforce personnel, except for ground crew, were also excluded, for reasons of possible increased past exposure to cosmic radiation. Vietnam veterans were also not included in either the control or veterans group in view of the risk that these people may have been adversely affected by exposure to defoliants (Rowland et al, 2007). To control for any environmental variation, selection of both veterans and controls was geographically stratified across the North Island of New Zealand.…”

Section: Methodsmentioning

confidence: 99%

Elevated chromosome translocation frequencies in New Zealand nuclear test veterans

Wahab

Nickless

Najar-M’Kacher

et al. 2008

Cytogenet Genome Res

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In 1957/58 the British Government conducted a series of nuclear tests in the mid-Pacific codenamed Operation Grapple, which involved several naval vessels from Britain and New Zealand. Two New Zealand frigates with 551 personnel onboard were stationed at various distances between 20 and 150 nautical miles from ground zero. In the present study we applied the cytomolecular technique mFISH (multicolour fluorescent in situ hybridisation) to investigate a potential link between chromosome abnormalities and possible past radiation exposure in New Zealand nuclear test veterans who participated in Operation Grapple. Compared to age matched controls, the veterans showed significantly higher (P < 0.0001) frequencies of chromosomal abnormalities (275 translocations and 12 dicentrics in 9,360 cells vs. 96 translocations and 1 dicentric in 9,548 cells in the controls), in addition to a significant excess of CCRs (complex chromosomal rearrangements) in the veterans. A Kolmogorov-Smirnoff test showed that the distributions of translocations for the two groups were significantly different.

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Section: Methodsmentioning

confidence: 99%

Elevated chromosome translocation frequencies in New Zealand nuclear test veterans

Wahab

Nickless

Najar-M’Kacher

et al. 2008

Cytogenet Genome Res

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“…The samples were then exposed to 1 μg/mL BrdU for 38 h and 20 ng/mL colcemid for 2 h in this study. But other literature, Rowland et al [16] said that “0.01 M BrdU was added to culture tube, After approximately 72 h, 100 μL of 0.05% colchicines was added. Thus, it is important to consider the significantly different methods between those groups.…”

Section: Resultsmentioning

confidence: 99%

“…Landgren et al [15], for example, found a significant correlation between α-naphthoflavone (ANF)-induced SCEs and serum concentrations of Polychlorinated Biphenyls (PCBs) and several PCB congeners in women from Yucheng. Likewise, the SCE frequency for New Zealand Vietnam veterans has been found to be higher than that for the control group [16]. …”

Section: Introductionmentioning

confidence: 99%

The Relationship between Dioxin Congeners in the Breast Milk of Vietnamese Women and Sister Chromatid Exchange

Suzuki

Kido

Okamoto

et al. 2014

IJMS

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The aim of this study was to clarify the relationship between dioxin concentrations in breast milk and the sister chromatid exchange (SCE) frequency in women from herbicide-sprayed and non sprayed areas. Blood samples were taken from 21 women with high TCDD (tetrachlorodibenzo-p-dioxin) levels from sprayed areas, 23 women with moderate TCDD levels from sprayed areas, and 19 women from non sprayed areas to determine their SCE frequency. The SCE frequencies for the high and moderate TCDD groups from the sprayed area and for the non sprayed area group were 2.40, 2.19, and 1.48 per cell, respectively. Multiple regression analysis showed that the standardized β values for 1,2,3,6,7,8-hexaCDD (β = 0.60), 1,2,3,4,6,7,8-heptaCDD (β = 0.64), and octaCDD (β = 0.65) were higher than those for TCDD (β = 0.34) and 1,2,3,7,8-pentaCDD (β = 0.42). The adjusted R2 value for polyCDDs (R2 = 0.38) was higher than that for polyCDD toxic equivalents (TEQ (toxic equivalents); R2 = 0.23). This study therefore shows that levels of hexa-, hepta-, and octaCDD, which were previously regarded as being less toxic than TCDD, are closely related to SCE frequency and that the level of dioxin (pg/g lipid) is potentially more useful as an indicator than TEQ value for explaining SCE frequency.

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“…Range from 1 to 24 years India Smoking and duration Pasquini (Pasquini et al, 1996) 1996 Farmers 18.35±12.42 years Italy Age, smoking and duration c Rowland (Rowland et al, 2007) 2007 War veterans Unknown New Zealand Age, smoking and drinking Rupa (Rupa et al, 1988) 1988 Vegetable gardens 20.24±7.77 years India Smoking and duration b Rupa (Rupa et al, 1989) 1989 Applicators in cotton fields 8 hours per day in the spring and winter India Duration and smoking seasons (range 1-25 years) Rupa (Rupa et al, 1991) 1991 Applicators in cotton fields 8 hours per day and 9 months per year India Duration Scarpato (Scarpato et al, 1996) 1996 Greenhouse floriculturists Unknown Italy Smoking and sex Shaham (Shaham et al, 2001) 2001 (DerSimonian et al, 1986). The Cochrane Q statistics test was performed for the assessment of heterogeneity among studies.…”

Section: Quantitative Data Synthesismentioning

confidence: 99%

“…Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers of cytogenetic damage. However, the results from epidemiological studies remained inconsistent and controversial (Bauchinger et al, 1982;Linnainmaa, 1983;Rupa et al, 1988;Jablonicka et al, 1989;De Ferrari et al, 1991;Rupa et al, 1991;Gomez-Arroyo et al, 1992;Carbonell et al, 1993;Lander et al, 1995;Hoyos et al, 1996;Kourakis et al, 1996;Pasquini et al, 1996;Scarpato et al, 1996;Joksic et al, 1997;Steenland et al, 1997;Gomez-Arroyo et al, 2000;Hatjian et al, 2000;Padmavathi et al, 2000;Shaham et al, 2001;Zeljezic et al, 2002;Suarez et al, 2003;Costa et al, 2006;Ergene et al, 2007;Rowland et al, 2007;Martinez-Valenzuela et al, 2009). In order to obtain a precise estimate of the association of SCE frequency with pesticide exposure, we collected published data to evaluate the validation of SCE in human peripheral blood lymphocytes as a cytogenetic biomarker of pesticideexposed population.…”

Section: Introductionmentioning

confidence: 99%

Increased Sister Chromatid Exchange in Peripheral Blood Lymphocytes from Humans Exposed to Pesticide: Evidence Based on a Meta-analysis

Yang¹,

Liu²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers employed to evaluate genetic damage subsequent to pesticide exposure. Objective: To estimate the pooled levels of SCE in human peripheral blood lymphocytes among population exposed to pesticide. Materials and Methods: Meta-analysis on the association between SCE frequency and pesticide exposure was performed with STATA 10.0 software package and Review Manager 5.0.24 in this study. Results: The overall means of SCE were 7.88 [95% confidence intervals (95%CI): 6.71-9.04] for exposure group and 6.05 (95%CI: 5.13-6.95) for controls, respectively. There was statistically significant difference in the SCE frequency in human peripheral blood lymphocytes between pesticide-exposed groups and control groups, and the summary estimate of weighted mean difference was 1.69 (95%CI: 1.01-2.38). We also observed that pesticide-exposed population had significantly higher SCE frequency than control groups among smokers, nonsmokers, pesticide applicator, pesticide producer, other exposure population and Asian population in stratified analyses. Conclusions: Data indicate that the SCE frequency in human peripheral blood lymphocytes might be an indicator of early genetic effects for pesticide-exposed populations. s Keywords: Sister chromatid exchange -pesticide -peripheral blood lymphocytes -meta-analysis

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Elevated sister chromatid exchange frequencies in New Zealand Vietnam War veterans

Cited by 11 publications

References 36 publications

Elevated chromosome translocation frequencies in New Zealand nuclear test veterans

Elevated chromosome translocation frequencies in New Zealand nuclear test veterans

The Relationship between Dioxin Congeners in the Breast Milk of Vietnamese Women and Sister Chromatid Exchange

Increased Sister Chromatid Exchange in Peripheral Blood Lymphocytes from Humans Exposed to Pesticide: Evidence Based on a Meta-analysis

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