Elevated Soluble Cellular Adhesion Molecules in Subjects With Low HDL-Cholesterol

Calabresi, Laura; Gomaraschi, Monica; Villa, Barbara; Omoboni, L.; Dmitrieff, Camille; Franceschini, Guido

doi:10.1161/hq0402.105901

“…Our results are consistent with other studies that have reported a negative correlation between the plasma concentration of HDLc and that of hsCRP in patients with low HDLc levels, but not in those with normal or elevated HDLc levels [23] [24].…”

Section: Discussionsupporting

confidence: 93%

Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group

Sendesni¹,

Lahidheb²,

Ayoub³

et al. 2016

OALib

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Aims: To evaluate the relationship between inflammatory biomarkers and lipid parameters in a Tunisian coronary artery disease group. Material and Methods: In the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed by coronary angiography, selected among patients admitted to the cardiology department and 162 subjects free of any cardiovascular disease, recruited from medical and paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory cytokines (IL6, IL8 and TNFα) were determined for all patients and controls. Results: A highly significant difference (P < 10 −3 ) was noted between the mean of the hsCRP in coronary patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We note also a significant difference between the means of IL6 in the diseased population (11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value of P < 10

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“…125 It was also found that the increase in HDL levels induced by treatment with fenofibrate was associated with a significant reduction in the plasma concentrations of sICAM-1 and sE-selectin. 125 It is unclear, however, whether the reduction in sICAM and sE-selectin was the consequence of the increase in HDL or a direct antiinflammatory effect of the fibrate on the artery wall.…”

Section: Clinical Implications Of Antioxidant/ Antiinflammatory Propementioning

confidence: 94%

Antiinflammatory Properties of HDL

Barter

¹

,

Nicholls

²

,

Rye

³

et al. 2004

Circulation Research

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Abstract-There are several well-documented functions of high-density lipoprotein (HDL) that may explain the ability of these lipoproteins to protect against atherosclerosis. The best recognized of these is the ability of HDL to promote the efflux of cholesterol from cells. This process may minimize the accumulation of foam cells in the artery wall. However, HDL has additional properties that may also be antiatherogenic. For example, HDL is an effective antioxidants. The major proteins of HDL, apoA-I and apoA-II, as well as other proteins such as paraoxonase that cotransport with HDL in plasma, are well-known to have antioxidant properties. As a consequence, HDL has the capacity to inhibit the oxidative modification of low-density lipoprotein (LDL) in a process that reduces the atherogenicity of these lipoproteins. HDL also possesses other antiinflammatory properties. By virtue of their ability to inhibit the expression of adhesion molecules in endothelial cells, they reduce the recruitment of blood monocytes into the artery wall. These antioxidant and antiinflammatory properties of HDL may be as important as its cholesterol efflux function in terms of protecting against the development of atherosclerosis.

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“…In a study of subjects with a wide range of HDL cholesterol concentrations, it was found that the plasma levels of soluble ICAM-1 and soluble E-selectin (but not soluble VCAM-1) were significantly higher in subjects with low HDL levels compared with those with average or high HDL levels. 125 Furthermore, the concentration of HDL cholesterol correlated inversely with both soluble ICAM-1 (sICAM-1) and soluble E-selectin (sE-selectin) in the low-HDL subjects but not in those with normal or elevated HDL levels. 125 It was also found that the increase in HDL levels induced by treatment with fenofibrate was associated with a significant reduction in the plasma concentrations of sICAM-1 and sE-selectin.…”

Section: Clinical Implications Of Antioxidant/ Antiinflammatory Propementioning

confidence: 93%

“…125 Furthermore, the concentration of HDL cholesterol correlated inversely with both soluble ICAM-1 (sICAM-1) and soluble E-selectin (sE-selectin) in the low-HDL subjects but not in those with normal or elevated HDL levels. 125 It was also found that the increase in HDL levels induced by treatment with fenofibrate was associated with a significant reduction in the plasma concentrations of sICAM-1 and sE-selectin. 125 It is unclear, however, whether the reduction in sICAM and sE-selectin was the consequence of the increase in HDL or a direct antiinflammatory effect of the fibrate on the artery wall.…”

mentioning

confidence: 93%

Anti-Inflammatory Properties of HDL

Ansell

¹

,

Navab

²

,

Watson

³

et al. 2004

Rev Endocr Metab Disord

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Abstract-There are several well-documented functions of high-density lipoprotein (HDL) that may explain the ability of these lipoproteins to protect against atherosclerosis. The best recognized of these is the ability of HDL to promote the efflux of cholesterol from cells. This process may minimize the accumulation of foam cells in the artery wall. However, HDL has additional properties that may also be antiatherogenic. For example, HDL is an effective antioxidants. The major proteins of HDL, apoA-I and apoA-II, as well as other proteins such as paraoxonase that cotransport with HDL in plasma, are well-known to have antioxidant properties. As a consequence, HDL has the capacity to inhibit the oxidative modification of low-density lipoprotein (LDL) in a process that reduces the atherogenicity of these lipoproteins. HDL also possesses other antiinflammatory properties. By virtue of their ability to inhibit the expression of adhesion molecules in endothelial cells, they reduce the recruitment of blood monocytes into the artery wall. These antioxidant and antiinflammatory properties of HDL may be as important as its cholesterol efflux function in terms of protecting against the development of atherosclerosis. Key Words: antiinflammatory Ⅲ antioxidant Ⅲ atherosclerosis Ⅲ high-density lipoprotein I n epidemiological studies, high plasma levels of highdensity lipoproteins (HDLs) protect against the development of atherosclerosis. 1,2 The precise mechanism is uncertain, although most likely it is the consequence of one or more of the reported actions of HDL. 3 The best known of these relates to the ability of HDL to promote the efflux of cholesterol from cells in the artery wall. 4 However, HDLs have additional functions, some of which may be unrelated to their role in plasma lipid transport. For example, they bind lipopolysaccharide, 5 stimulate endothelial cell movement, 6 inhibit the synthesis of plateletactivating factor by endothelial cells, 7 and protect erythrocytes against the generation of procoagulant activity. 8 HDLs stimulate prostacyclin synthesis by endothelial cells. 9 They also bind prostacyclin and thus prolong its half-life. 10 They reduce epidermal growth factor-induced DNA synthesis in vascular smooth muscle cells. 11 HDLs are antithrombotic. 12 They modulate endothelial function, 13 probably by stimulating endothelial nitric oxide (NO) production. 14 HDLs also possess antioxidant and antiinflammatory activities. 3,[15][16][17][18][19][20][21] The degree to which any or all of these nonlipid transport functions of HDL contribute to a protection against atherosclerosis is still uncertain, although evidence is mounting that at least some of them may be especially important.This review focuses on the antioxidant and antiinflammatory properties of HDL (Figure 1). It summarizes the role of oxidation and inflammation in atherogenesis and describes how these processes may be inhibited by HDL. It concludes with an assessment of the potential clinical importance of the antioxidant and antiinflammatory propert...

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Elevated Soluble Cellular Adhesion Molecules in Subjects With Low HDL-Cholesterol

Cited by 118 publications

References 56 publications

Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group

Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group

Antiinflammatory Properties of HDL

Anti-Inflammatory Properties of HDL

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