2013
DOI: 10.2215/cjn.01910213
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Elevated Subclinical Double-Stranded DNA Antibodies and Future Proliferative Lupus Nephritis

Abstract: SummaryBackground and objectives Elevated anti-double-stranded DNA (dsDNA) antibody and C-reactive protein are associated with proliferative lupus nephritis (PLN). Progression of quantitative anti-dsDNA antibody in patients with PLN has not been compared with that in patients with systemic lupus erythematosus (SLE) without LN before diagnosis. The temporal relationship between anti-dsDNA antibody and C-reactive protein elevation has also not been evaluated.Design, setting, participants, & measurements This cas… Show more

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Cited by 39 publications
(34 citation statements)
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“…Patients with nephritis associated features such as impaired renal function and dsDNA positivity[35] were also affected with more plaques than their matched controls. Associations with enhanced measures of atherosclerosis have also been reported [36, 37].…”
Section: Discussionmentioning
confidence: 99%
“…Patients with nephritis associated features such as impaired renal function and dsDNA positivity[35] were also affected with more plaques than their matched controls. Associations with enhanced measures of atherosclerosis have also been reported [36, 37].…”
Section: Discussionmentioning
confidence: 99%
“…The significance of self-reacting B-cells in the pathogenesis of LN is supported by a strong causal link between autoantibodies against double stranded DNA (dsDNA) and renal involvement [3,4]. Additionally, rise in the titer of anti-dsDNA antibodies occurs years before the clinical onset of proliferative LN [5,6]. It has been suggested that autoimmune inflammation results from repeated stimulation of autoreactive memory T-and B-cells, and subsequent effector responses mediated in part by circulating autoantibodies.…”
Section: Introductionmentioning
confidence: 99%
“…This is analogous to our work in autoimmune kidney diseases, in which we have demonstrated preclinical autoantibodies above thresholds within the accepted normal range compared with matched controls. 9,15,16 In AL amyloidosis, the concentration of the M-Ig is generally modest when compared with that in MM. 17 The pathogenesis of AL amyloidosis is driven by misfolded LCs, which form an insoluble ␤-pleated conformation that deposits in tissues resulting in organ dysfunction.…”
Section: Discussionmentioning
confidence: 99%