Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI

Ouwerkerk, Ronald; Jacobs, Michael A.; Macura, Katarzyna J.; Wolff, Antonio C.; Stearns, Vered; Mezban, Sarah D.; Khouri, Nagi F.; Bluemke, David A.; Bottomley, Paul A.

doi:10.1007/s10549-006-9485-4

Cited by 178 publications

(182 citation statements)

References 34 publications

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“…It is also of note that elevated NHE1 activity contributes of sodium loading of cells. Elevated sodium loading by NHE1 and other sodium loading proteins such as sodium channels and Na + /HCO3 -co-transport, may promote mitogenesis and/or oncognesis [26][27][28][29][30] and elevated tissue sodium is reported in malignant breast cancer [31] and other cancer types [32,33]. Thus elevated NHE1 activity may contribute to oncogenesis by more than one mechanism.…”

Section: Discussionmentioning

confidence: 99%

Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells

Amith

Vincent

Wilkinson

et al. 2017

Cellular Signalling

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Section: Discussionmentioning

confidence: 99%

Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells

Amith

Vincent

Wilkinson

et al. 2017

Cellular Signalling

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“…To quantify the TSC (combined intracellular and extracellular 23 Na) in the rat brain, the approach of Ouwerkerk et al was adapted (19). In addition to scanning the rat head, a separate scan was acquired of a homogeneous reference phantom of diameter 40 mm containing 120 mM NaCl dissolved in distilled water and suspended in a 1% agarose gel.…”

Section: Quantitativementioning

confidence: 99%

Regional and temporal variations in tissue sodium concentration during the acute stroke phase

Wetterling

Gallagher

Macrae

et al. 2011

Magnetic Resonance in Med

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A technique for noninvasively quantifying the concentration of sodium (23Na) ions was applied to the study of ischemic stroke. 23Na‐magnetic resonance imaging techniques have shown considerable potential for measuring subtle changes in ischemic tissue, although studies to date have suffered primarily from poor signal/noise ratio. In this study, accurate quantification of tissue sodium concentration (TSC) was achieved in 23Na images with voxel sizes of 1.2 μL acquired in 10 min. The evolution of TSC was investigated from 0.5 to 8 h in focal cortical and subcortical ischemic tissue following permanent middle cerebral artery occlusion in the rat (n = 5). Infarct volumes determined from TSC measurements correlated significantly with histology (P = 0.0006). A delayed linear model was fitted to the TSC time course data in each voxel, which revealed that the TSC increase was more immediate (0.2 ± 0.1 h delay time) in subcortical ischemic tissue, whereas it was delayed by 1.6 ± 0.5 h in ischemic cortex (P = 0.0002). No significant differences (P = 0.5) were measured between TSC slope rates in cortical (10.2 ± 1.1 mM/h) and subcortical (9.7 ± 1.1 mM/h) ischemic tissue. The data suggest that any TSC increase measured in ischemic tissue indicates infarction (core) and regions exhibiting a delay to TSC increase indicate potentially salvageable tissue (penumbra). Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.

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“…The potential diagnostic benefits of 23 Na-MR imaging have recently been demonstrated for common pathological conditions such as tumor [5,6], stroke [7][8][9], Alzheimer disease [10], paramyotonia [11], arthritis [12], multiple sclerosis [13] and functional renal imaging [14] in humans. In addition, pre-clinical in vivo 23 Na MRI enables one to temporally follow pathological progression in animal models of common human disease [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

Wetterling

Högler

Molkenthin

et al. 2012

Journal of Magnetic Resonance

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The design and construction of a two-port surface transceiver resonator for both 1 H-and 23 Na-MRI in the rodent brain at 7T is described. Double-tuned resonators are required for accurately co-registering multi-nuclei data sets, especially when the time courses of 1 H and 23 Na signals are of interest as, for instance, when investigating the pathological progression of ischaemic stroke tissue in vivo. In the current study, a single-element two-port surface resonator was developed wherein both frequency components were measured with the same detector element but with each frequency signal routed along different output channels.This was achieved by using the null spot technique, allowing for optimal variable tuning and matching of each channel in situ within the MRI scanner. The 23 Na signal to noise ratio, measured in the ventricles of the rat brain, was increased by a factor of four compared to recent state-of-the-art rat brain studies reported in the literature. The resonator's performance was demonstrated in an in vivo rodent stroke model, where regional variations in 1 H apparent diffusion coefficient maps and the 23 Na signal were recorded in an interleaved fashion as a function of time in the acute phase of the stroke without having to exchange, re-adjust, or re-connect resonators between scans. Using the practical construction steps described in this paper, this coil design.

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Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI

Abstract: Elevated TSC in breast lesions measured by non-invasive (23)Na MRI appears to be a cellular-level indicator associated with malignancy. This method may have potential to improve the specificity of breast MRI with only a modest increase in scan time per patient.

Cited by 178 publications

References 34 publications

Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells

Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells

Regional and temporal variations in tissue sodium concentration during the acute stroke phase

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

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