Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Ko, Byung Joon; Lee, Myoungsook; Park, Hye Soon; Han, Kyungdo; Cho, Geum Joo; Hwang, Taik Gun; Kim, Junghwan; Lee, Seung Hwan; Lee, Hye Young; Kim, Seon Mee

doi:10.1507/endocrj.ej12-0384

Cited by 22 publications

(14 citation statements)

References 36 publications

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“…These results confirm earlier studies [36][37][38][39][40]. Further, both adipokines were associated with central obesity markers, lipid metabolism, and insulin resistance.…”

Section: Discussionsupporting

confidence: 92%

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Simões

Domingos

Oliveira

et al. 2018

Nutrire

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Background: The evidence that cardiovascular disease begins in childhood and adolescence, especially in the presence of excess weight, is associated with dysfunction on adipokine pro-inflammatory secretion. These affect glucose metabolism and lead to other complications related to insulin resistance and cardiovascular disease. This study assessed the association of anthropometric and metabolic parameters related to obesity, cardiovascular risk, and insulin resistance with concentrations of resistin and visfatin, in children. Methods: A cross-sectional study was developed with 178 children of 6-10 years old enrolled in public city schools. Anthropometric data, composition body, clinical, and biochemical were measured according to standard procedures. We used multiple regression models by stepwise method to evaluate the associations of resistin and visfatin with variables of interest. Results: In healthy weight children, resistin was associated with LDL cholesterol, visfatin, atherogenic index, and waist-to-height ratio, whereas in obese children resistin was associated with visfatin and interaction between conicity index and HOMA-AD. Furthermore, in healthy weight children, visfatin was associated to resistin and triceps skinfold thickness and negatively associated to HOMA-AD, while in obese ones visfatin was associated with waistto-height ratio, atherogenic index, resistin, and interaction between trunk adiposity index and adiponectin and was negatively associated with the HOMA-IR index. Conclusions: Our study shows an association between anthropometric and biochemical variables related to visceral fat and inflammation. These results suggest the resistin and visfatin as good pro-inflammatory markers. In addition, both adipokines are strongly related to central obesity, in children.

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“…These results confirm earlier studies [36][37][38][39][40]. Further, both adipokines were associated with central obesity markers, lipid metabolism, and insulin resistance.…”

Section: Discussionsupporting

confidence: 92%

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Simões

Domingos

Oliveira

et al. 2018

Nutrire

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“…As far as younger populations are concerned, Körner et al observed that vaspin increased with puberty in girls, but not in boys [ 40 ]. Ko et al did not find gender differences in serum vaspin levels when pre-pubertal Korean children were studied [ 55 ]. This is in accordance with the study reported by Körner et al which shows that gender differences arise during pubertal progression in girls and are not present in pre-pubertal children [ 40 ].…”

Section: Vaspinmentioning

confidence: 99%

Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development

Escoté

Gómez‐Zorita

López-Yoldi

et al. 2017

IJMS

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Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed. Vaspin is produced by visceral and subcutaneous adipose tissues. Vaspin levels are higher in obese subjects, as well as in subjects showing insulin resistance or type 2 diabetes. Cardiotrophin-1 is an adipokine with a similar structure as cytokines from interleukin-6 family. There is some controversy regarding the regulation of cardiotrophin-1 levels in obese -subjects, but gene expression levels of cardiotrophin-1 are down-regulated in white adipose tissue from diet-induced obese mice. It also shows anti-obesity and hypoglycemic properties. TWEAK is a potential regulator of the low-grade chronic inflammation characteristic of obesity. TWEAK levels seem not to be directly related to adiposity, and metabolic factors play a critical role in its regulation. Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions.

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“…Vaspin (visceral adipose tissue-derived serine protease inhibitor) is mainly produced from visceral adipose tissue [ 181 ]. It improves insulin sensitivity in preclinical models by inducing GLUT-4 expression [ 182 ].…”

Section: Novel Adipokinesmentioning

confidence: 99%

State of the art paper Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns

Papaetis¹,

Papakyriakou²,

Panagiotou³

2015

aoms

121

103

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The prevalence of type 2 diabetes (T2D) is rapidly increasing. This is strongly related to the contemporary lifestyle changes that have resulted in increased rates of overweight individuals and obesity. Central (intra-abdominal) obesity is observed in the majority of patients with T2D. It is associated with insulin resistance, mainly at the level of skeletal muscle, adipose tissue and liver. The discovery of macrophage infiltration in the abdominal adipose tissue and the unbalanced production of adipocyte cytokines (adipokines) was an essential step towards novel research perspectives for a better understanding of the molecular mechanisms governing the development of insulin resistance. Furthermore, in an obese state, the increased cellular uptake of non-esterified fatty acids is exacerbated without any subsequent β-oxidation. This in turn contributes to the accumulation of intermediate lipid metabolites that cause defects in the insulin signaling pathway. This paper examines the possible cellular mechanisms that connect central obesity with defects in the insulin pathway. It discusses the discrepancies observed from studies organized in cell cultures, animal models and humans. Finally, it emphasizes the need for therapeutic strategies in order to achieve weight reduction in overweight and obese patients with T2D.

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Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Cited by 22 publications

References 36 publications

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development

State of the art paper Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns

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