Elevated XPO6 expression as a potential prognostic biomarker for prostate cancer recurrence

Wang, Yuzhuo

doi:10.2741/s445

Cited by 16 publications

(10 citation statements)

References 49 publications

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“…XPO6 was overexpressed and associated with metastatic potential and a poor prognosis in prostate cancer tissue [54]. Consistent with these findings, our analysis revealed higher XPO6 mRNA expression in HCC cancerous tissues compared with paracancerous liver tissues, and it was significantly related to HCC clinical stage and pathological grade.…”

Section: Discussionsupporting

confidence: 86%

Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma

et al. 2019

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Aims: A large number of studies have suggested that exportins (XPOs) play a pivotal role in human cancers. In the present study, we analyzed XPO mRNA expression in cancer tissues and explored their prognostic value in hepatocellular carcinoma (HCC). Methods: Transcriptional and survival data related to XPO expression in HCC patients were obtained through the ONCOMINE and UALCAN databases. Survival analysis plots were drawn with Gene Expression Profiling Interactive Analysis (GEPIA). Sequence alteration data for XPOs were obtained from The Cancer Genome Atlas (TCGA) database and c-BioPortal. Gene functional enrichment analyses were performed with Database for Annotation, Visualization and Integrated Discovery (DAVID). Results: Compared with normal liver tissues, significant XPO mRNA overexpression was observed in HCC cancer tissues. There was a trend of higher XPO expression in more advanced clinical stages and lower differentiated pathological grades of HCC. In HCC patients, high expression of XPO1, CSE1L, XPOT, XPO4/5/6 was related to poor overall survival (OS), and XPO1, CSE1L and XPO5/6 were correlated with poor disease-free survival (DFS). The main genetic alterations in XPOs involved mRNA up-regulation, DNA amplification and deletion. General XPO mutations were remarkably associated with worse OS and mostly affected the pathways of RNA transport and oocyte meiosis. Conclusion: High expression of XPOs was associated with a poor prognosis in HCC patients. XPOs may be exploited as good prognostic biomarkers for survival in HCC patients.

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Section: Discussionsupporting

confidence: 86%

Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma

et al. 2019

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“…In addition, TSR2 variation is associated with Diamond-Blackfan anemia (DBA) (Clinton and Gazda, 2009). As a nucleocytoplasmic transporter, XPO6 expression is closely related to poor prognosis of patients and is a potential prognostic biomarker for prostate cancer (Hao et al, 2016). ISG20 is involved in small nucleolar RNA maturation and ribosomal biogenesis, and controls RNA stability (Espert et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Systematic Construction and Validation of an RNA-Binding Protein-Associated Prognostic Model for Acute Myeloid Leukemia

Luo

Zhang

et al. 2021

Front. Genet.

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Background: The abnormal expression of RNA-binding proteins (RBPs) in various malignant tumors is closely related to the occurrence and development of tumors. However, the role of RBPs in acute myeloid leukemia (AML) is unclear.Methods: We downloaded harmonized RNA-seq count data and clinical data for AML from UCSC Xena, including The Cancer Genome Atlas (TCGA), The Genotype-Tissue Expression (GTEx), and Therapeutically Applicable Research to Generate Effective Treatments (TARGET) cohorts. R package edgeR was used for differential expression analysis of 337 whole-blood data and 173 AML data. The prognostic value of these RBPs was systematically investigated by using univariate Cox regression analysis, least absolute shrinkage and selection operator (LASSO)–Cox regression analysis, and multivariate Cox regression analysis. C-index and calibration diagram were used to judge the accuracy of the model, and decision curve analysis (DCA) was used to judge the net benefit. The biological pathways involved were revealed by gene set enrichment analysis (GSEA). The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and the protein–protein interaction (PPI) network performed lateral verification on the selected gene set and LASSO results.Results: A prognostic model of 12-RBP signature was established. In addition, the net benefit and prediction accuracy of the prognostic model and the mixed model based on it were significantly higher than that of cytogenetics. It is verified in the TARGET cohort and shows good prediction effect. Both the selection of our gene set and the LASSO results have high credibility. Most of these pathways are involved in the development of the disease, and they also accumulate in leukemia and RNA-related pathways.Conclusion: The prognosis model of the 12-RBP signature found in this study is an optimized biomarker that can effectively stratify the risk of AML patients. Nomogram based on this prognostic model is a reliable method to predict the median survival time of patients. This study expands our current understanding of the role of RBPs in the occurrence of AML and may lay the foundation for future treatment of the disease.

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“…This proposed mechanism along with statistical analysis of clinical datasets, led to the proposal that XPO6 expression correlates with poor survival in breast cancer patients. On the other hand, gene expression analysis of samples from prostate cancer patients showed that elevated levels of XPO6 can be used a prognostic marker of reoccurrence [61,62].…”

Section: Kap-mediated Nuclear Export and Cancermentioning

confidence: 99%

Karyopherins in cancer

Çağatay

Chook

2018

Current Opinion in Cell Biology

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Malfunction of nuclear-cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.

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Elevated XPO6 expression as a potential prognostic biomarker for prostate cancer recurrence

Cited by 16 publications

References 49 publications

Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma

Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma

Systematic Construction and Validation of an RNA-Binding Protein-Associated Prognostic Model for Acute Myeloid Leukemia

Karyopherins in cancer

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