Eleven New 2‐Pyrones from a Fungi Imperfecti, Trichurus terrophilus, Found in a Screening Study Guided by Immunomodulatory Activity.

Abstract

Eleven New 2-Pyrones from a Fungi Imperfecti, Trichurus terrophilus, Found in a Screening Study Guided by Immunomodulatory Activity. -Solvent partitions followed by repeated chromatographic fractionations of the Et-O-Ac extract of T. terrophilus, guided by immunosuppressive activity, affords eleven new pyrones such as (I) and (II), tentatively named TT-1-11. Pyrones (Ia)-(Ic) and (II) display considerably high immunosuppressive activities while compounds (If)-(Ih) are of moderate activity. The structure-activity relationships of these constituents are discussed. -(FUJIMOTO*, H.; OKAMOTO, Y.; SONE, E.; MAEDA, S.; AKIYAMA, K.; ISHIBASHI, M.; Chem. Pharm. Bull. 53 (2005) 8, 923-929; Grad. Sch. Pharm. Sci., Chiba Univ., Inage, Chiba 263, Japan; Eng.) -H. Hoennerscheid 03-208