Eleventh Annual International Neurologic Assembly

Winkler, Amanda Eubanks; Bedo, de; Purves-Stewart, James; Negro, Fedele

doi:10.1001/archneurpsyc.1931.02230030215011

Cited by 3 publications

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“…In Germany, Creutzfeldt and Metz ( 1926 ), following up on the earlier work by Metz and Spatz ( 1924 ), charted the involvement of microglia ('Hortegazellen') in acute as well as chronic degenerative processes, progressive paralysis, in tuberculous meningitis, in presenile dementia, and the specifi c association of these cells with senile plaques (Creutzfeldt and Metz 1926 ; see also Timmer 1925 for an early discussion on the relationship between microglia and senile plaques). By 1930, the concepts of microglia and of oligdendroglia were fi rmly established, as can be read in the Society Transactions of the 11th Annual International Neurologic Assembly, held in Paris (Winkler et al 1931 ). The mesodermal nature of microglia, however, was not universally accepted.…”

Section: The 'Dawn' and 'Early' Phases Of Microglia Researchmentioning

confidence: 99%

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CHAPTER 2: Historical Context

2017

Pictures of the Heart

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The term 'microglia' was fi rst introduced into the scientifi c literature almost a century ago. The various eras of microglia research have not only been defi ned by the number of reports subsequently generated but, more critically, by the concepts that have shaped our present-day views and understanding of microglia. Key methods, technologies, and models as well as seminal discoveries made possible through their deployment have enabled breakthroughs, and now pave the way for lines of investigation that could not have been anticipated even a decade ago. Advances in our understanding of microglial origin, forms, and functions have relied fundamentally on parallel developments in immunology. As the 'neuro-immune' cells of the brain, microglia are now under the spotlight in various disciplines. This chapter surveys the gradual processes and precipitous events that helped form ideas concerning the developmental origin of microglia and their roles in health and disease. It covers fi rst the dawning phase during which the early pioneers of microglia research discovered cellular entities and already assigned functions to them. Following a recess period, the 1960s brought a renaissance of active interest, with a development of tools and models-and fundamental notions on microglial contributions to central nervous system pathologies. These seminal efforts laid the fundament for the awakening of a sweeping research era beginning with 1980s and being spurred on by a blast of immunological discoveries. Finally, the chapter stresses the advancement of molecular, genetic as well as imaging approaches to the study of microglia with the turn of the millennium, enabling insights into virtually all facets of microglial physiology. Moving forward it is clear that the future holds substantial promise for further discoveries. The next epoch in the history of microglia research has just begun.

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Section: The 'Dawn' and 'Early' Phases Of Microglia Researchmentioning

confidence: 99%

“…Others (e.g. Polderman 1926 ;Schaffer 1926 ;Pruijs 1927 ), while accepting that microglia were a class apart from astrocytes (the 'macroglia'), questioned whether these cells could in fact be derived from the neuropeithelium (see Winkler et al 1931 ).…”

Section: The 'Dawn' and 'Early' Phases Of Microglia Researchmentioning

confidence: 99%