Eliminating Absence Seizures through the Deep Brain Stimulation to Thalamus Reticular Nucleus

Wang, Zhihui; Wang, Qingyun

doi:10.3389/fncom.2017.00022

Cited by 30 publications

(25 citation statements)

References 43 publications

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“…Neural field models (Taylor et al, 2014; Wang and Wang, 2017) have been successfully applied to investigate the effect of stimulation on the SWD of absence seizures in epilepsy. As seen in Figure 2, the thalamocortical loop consists of cortical subsystem and thalamic subsystem.…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures

Fan

Duan

Wang

et al. 2017

Front. Comput. Neurosci.

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The mechanisms underlying electrophysiologically observed two-way transitions between absence and tonic-clonic epileptic seizures in cerebral cortex remain unknown. The interplay within thalamocortical network is believed to give rise to these epileptic multiple modes of activity and transitions between them. In particular, it is thought that in some areas of cortex there exists feedforward inhibition from specific relay nucleus of thalamus (TC) to inhibitory neuronal population (IN) which has even more stronger functions on cortical activities than the known feedforward excitation from TC to excitatory neuronal population (EX). Inspired by this, we proposed a modified computational model by introducing feedforward inhibitory connectivity within thalamocortical circuit, to systematically investigate the combined effects of feedforward inhibition and excitation on transitions of epileptic seizures. We first found that the feedforward excitation can induce the transition from tonic oscillation to spike and wave discharges (SWD) in cortex, i.e., the epileptic tonic-absence seizures, with the fixed weak feedforward inhibition. Thereinto, the phase of absence seizures corresponding to strong feedforward excitation can be further transformed into the clonic oscillations with the increasing of feedforward inhibition, representing the epileptic absence-clonic seizures. We also observed the other fascinating dynamical states, such as periodic 2/3/4-spike and wave discharges, reversed SWD and clonic oscillations, as well as saturated firings. More importantly, we can identify the stable parameter regions representing the tonic-clonic oscillations and SWD discharges of epileptic seizures on the 2-D plane composed of feedforward inhibition and excitation, where the physiologically plausible transition pathways between tonic-clonic and absence seizures can be figured out. These results indicate the functional role of feedforward pathways in controlling epileptic seizures and the modified thalamocortical model may provide a guide for future efforts to mechanistically link feedforward pathways in the pathogenesis of epileptic seizures.

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Section: Introductionmentioning

confidence: 99%

Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures

Fan

Duan

Wang

et al. 2017

Front. Comput. Neurosci.

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“…In a recent follow-up study, Wang et al [ 64 ] employed a mean-field modeling approach and found that the slow kinetics of GABA B receptors on thalamus reticular nucleus (TRN) lead to spike-wave discharges (SWDs). The deep brain stimulation (DBS) was applied to the TRN which helped in eliminating the SWDs.…”

Section: Discussionmentioning

confidence: 99%

Characterisation of ictal and interictal states of epilepsy: A system dynamic approach of principal dynamic modes analysis

et al. 2018

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Epilepsy is a brain disorder characterised by the recurrent and unpredictable interruptions of normal brain function, called epileptic seizures. The present study attempts to derive new diagnostic indices which may delineate between ictal and interictal states of epilepsy. To achieve this, the nonlinear modeling approach of global principal dynamic modes (PDMs) is adopted to examine the functional connectivity of the temporal and frontal lobes with the occipital brain segment using an ensemble of paediatric EEGs having the presence of epileptic seizure. The distinct spectral characteristics of global PDMs are found to be in line with the neural rhythms of brain dynamics. Moreover, we find that the linear trends of associated nonlinear functions (ANFs) associated with the 2nd and 4th global PDMs (representing delta, theta and alpha bands) of Fp1–F3 may differentiate between ictal and interictal states of epilepsy. These findings suggest that global PDMs and their associated ANFs may offer potential utility as diagnostic neural measures for ictal and interictal states of epilepsy.

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“…Intensively developed investigations of genetic forms of absence seizures performed during the last decades [10][11][12][13][14]. Calcium channel deteriorations may underlay such hyperactive state of neurons within the CTC networks due to an with the two-phase effects of vigabatrin upon SWD [29] and with the suppression of SWD caused by DBS of RT [30].…”

Section: Introductionmentioning

confidence: 99%

“…Searching for alternative therapy of not-responsive AS targets for DBS proved promising [35]. Among others, thalamic structures are the first line of such targets [30,35,36], while the cerebellum is almost beyond the scope of interest. Hence, our investigation aimed to observe the specificity evolution of interictal penicillin-induced cortical focal activity, emphasizing slow-wave characteristics, and spikes PPC under paleocerebellar electrical stimulation (ES).…”

Section: Introductionmentioning

confidence: 99%

Cerebellar Contribution to Absence Epilepsy

Godlevsky

Pinyazhko

Poshyvak

2020

Preprint

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The new aggregate data analyses revealed the earlier missing role played by the cerebellum long-term electrical stimulation in the absence epilepsy. Neurophysiologic data gained by authors favor that cerebellar serial deep brain stimulation (DBS) (100 Hz) causes the transformation of penicillin-induced cortical focal discharges into prolonged 3,5-3,75 sec oscillations resembling spike-wave discharges (SWD) in cats. Such SWDs were not organized in the form of bursts and persisted continuously after stimulation. Therefore the appearance of prolonged periods of SWD is regarded as a tonic cerebellar influence upon pacemaker of SWD and might be caused by the long-lasting DBS-induced increase of GABA-ergic extrasynaptic inhibition in forebrain networks. At the same time, cerebellar DBS high-frequency (100 Hz) suppressed bursts of SWD observed during the phase of stimulation. Different types of cerebellar DBS upon epileptic activity emphasized the absence seizure facilitation discussed with the reviewed data on optogenetic stimulation, neuronal activity of cerebellar structures, and functional magnetic resonance imaging data.

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Eliminating Absence Seizures through the Deep Brain Stimulation to Thalamus Reticular Nucleus

Cited by 30 publications

References 43 publications

Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures

Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures

Characterisation of ictal and interictal states of epilepsy: A system dynamic approach of principal dynamic modes analysis

Cerebellar Contribution to Absence Epilepsy

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