Elimination Pattern and Tissue Distribution of Intravenous Iron‐poly (sorbitol‐gluconic acid) Complex in the Rat

Abstract

The elimination pattern and tissue distribution in rats of intravenous ['4C-gluconic acid]poly(sorbito1-gluconic acid) and 59Fe-iron-poly(sorbitol-gluconic acid) complex, glusoferron (Ferastrala) have been examined. Twenty-four hours after injection of 20 or 200 mg/kg of ['4C-gluconic acid]-poly(sorbitolgluconic acid), 5%-6% of the injected dose of radiolabel was eliminated as I4CO2 and about 85% in the urine and faeces. Administration of S9Fe-iron-poly(sorbitol-gluconic acid) complex (10 and 100 mg of iron/kg) resulted in a urinary and faecal excretion of about 18% and 40% of the given dose, respectively, during the first 4 days. Biliary excretion was low. The mean molecular weight of the biliary product after the iron complex was lower than that of the parent compound. Radiocarbon in tissues after 24 hours was negligible. Liver and bones accounted for most of the retained radioiron following 100 mg of iron/kg bodyweight of the "Fe-iron complex with maximum levels of 27% and 12% of the injected dose, respectively, 4 days after dosing. Red cell incorporation of "Fe attained a level of 16% at the end of 28 days.