Ellipsoid zone optical intensity reduction as an early biomarker for retinitis pigmentosa

Gong, Yuting; Chen, Li Jia; Pang, Chi Pui; Chen, Haoyu

doi:10.1111/aos.14542

Cited by 13 publications

(12 citation statements)

References 35 publications

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“…Compared to the disruption of the hyperre ective bands at the outer retina, quantitative measurement of the thickness and optical intensity of the photoreceptors are earlier biomarkers of photoreceptor degeneration. [10][11][12] Our study found that these biomarkers declined before disappearing eccentrically, except IST and IZ-ROI. Hood and colleagues reported that the OST and ONLT gradually declined at the transition zone between normal and severely affected areas in RP.…”

Section: Discussionsupporting

confidence: 49%

“…In the literature, there were several reports of the association of OCT biomarkers with visual acuity, such as the presence of EZ at fovea [19], length of the IZ, [17] thickness of outer segments and full thickness of photoreceptor, [22][23][24] and optical intensity of EZ. [10] In our work, the mean IST within the central 1-mm-wide retinal area had the greatest correlation with BCVA among these metrics. Considering the inner segment ellipsoid of photoreceptor consisting of a thick density of mitochondria, which provides energy, [25] its structural integrity and intact function may be valuable to preserve visual function.…”

Section: Discussionsupporting

confidence: 45%

“…The participants have been described in our previous study. [10] The diagnosis of RP was based on clinical history, ophthalmoscopy, and electroretinography. The controls were free from ocular diseases except cataract, conjunctivitis, dry eye or refractive error.…”

Section: Study Subjectsmentioning

confidence: 99%

“…[7][8][9] With advanced image analysis techniques, some parameters of the photoreceptors can be measured. In our previous study, we demonstrated in retinitis pigmentosa (RP) patients that the relative optical intensity (ROI) of EZ and IZ declined in the regions where it remained intact on B scan [10]. Furthermore, the EZ-ROI at the fovea was correlated with visual acuity.…”

Section: Introductionmentioning

confidence: 97%

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Optical coherence tomography biomarkers of photoreceptor degeneration in retinitis pigmentosa

Gong

Zhang

et al. 2021

Int Ophthalmol

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Purpose: Several parameters on optical coherence tomography (OCT) have been suggested as biomarkers for photoreceptor degeneration in retinitis pigmentosa (RP). This study is to investigate which OCT parameters can serve as the earliest biomarkers in RP. Methods: OCT line scans of the horizontal meridian were conducted in 22 eyes of 22 RP patients and 30 eyes of 30 healthy controls. Longitudinal re ectance pro les were obtained using ImageJ at every 5 pixels. The following parameters on OCT were quantitatively measured: 1) relative optical intensity (ROI) of ellipsoid zone (EZ) and interdigitation zone (IZ); 2) thickness of outer nuclear layer (ONLT), photoreceptor (PRT), inner segment (IST) and outer segment (OST). The variations of these parameters across different regions were analyzed.Results: From fovea to peripheral retina, all the OCT biomarkers declined before disappeared, except IST and IZ-ROI. There was no identi able declining zone for the IST and IZ-ROI between the normal and disappeared zones. The earliest biomarker was the shortening of OST and reduced IZ-ROI, followed by the shortening of PRT, EZ-ROI, then IST, and nally, ONLT. All these biomarkers had signi cant correlations with best-corrected visual acuity, except ONLT. Conclusion:In retinitis pigmentosa, EZ-ROI, IZ-ROI, PRT, OST, IST and ONLT are valuable biomarkers of photoreceptor degeneration. OST and IZ-ROI may serve as the earliest biomarkers.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionsupporting

confidence: 45%

Section: Study Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Optical coherence tomography biomarkers of photoreceptor degeneration in retinitis pigmentosa

Gong

Zhang

et al. 2021

Int Ophthalmol

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“…Reflectance profiles were taken in an automated fashion using a customized script including plot profile extraction in Fiji. This approach has been described elsewhere as a robust method to access EZ integrity [ 11 , 19 , 20 ]. Manual adjustment was not applied.…”

Section: Methodsmentioning

confidence: 99%

Ellipsoid Zone Integrity and Visual Acuity Changes during Diabetic Macular Edema Therapy: A Longitudinal Study

Kessler

Bagautdinov

Khoramnia

2021

Journal of Diabetes Research

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Purpose. Ellipsoid zone (EZ) integrity is identified as a potential biomarker for therapy surveillance and outcome prediction of visual acuity (VA). However, only a few studies report long-term results of over 1 year of clinical and anatomical changes in patients with diabetic macular edema (DME). This study is aimed at describing the long-term VA and anatomical outcomes in spectral domain optical coherence tomography (OCT) (relative ellipsoid zone reflectivity ratio, central macular thickness, and volume) in patients with DME treated with antivascular endothelial growth factor (anti-VEGF) therapy. Furthermore, we studied the correlation between EZ integrity and changes in visual acuity. Methods. 71 eyes of 71 patients were included in this retrospective study. Clinical characteristics were reviewed yearly. OCT data were assessed at baseline and after 1, 3, and 5 years. EZ parameters were quantified automatically. OCT parameters and visual outcome were correlated and analyzed in multivariable regression models. Results. EZ reflectivity ratio correlated with functional outcome in DME patients from baseline to fifth year at all time points (for all p < 0.05 ). EZ reflectivity improved the most in the first year of treatment (0.68 to 0.75; p < 0.05 ) and declined gradually until year 5 of therapy (0.71; compared to baseline p > 0.05 ). Similarly, best VA was achieved after 1 year (0.40 logarithm of the minimum angle of resolution (logMAR) to 0.28 logMAR; p < 0.001 ) and declined gradually until year 5. Final VA in year 5 was comparable to baseline (0.45 logMAR, compared to baseline p > 0.05 ). Together with baseline VA, baseline EZ parameters did predict VA outcome after 1 year ( p < 0.05 ). Concordantly, VA and EZ parameters from year 1 were associated with VA outcome in year 2. Conclusion. This study described the long-term course of EZ changes during anti-VEGF treatment in DME patients. In addition, our results underlined the potential of EZ parameters as novel OCT biomarkers for prediction of VA outcomes during therapy.

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Alterations of outer retinal reflectivity in diabetic patients without clinically detectable retinopathy

Zhang,

Du,

Zhang

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Ellipsoid zone optical intensity reduction as an early biomarker for retinitis pigmentosa

Cited by 13 publications

References 35 publications

Optical coherence tomography biomarkers of photoreceptor degeneration in retinitis pigmentosa

Optical coherence tomography biomarkers of photoreceptor degeneration in retinitis pigmentosa

Ellipsoid Zone Integrity and Visual Acuity Changes during Diabetic Macular Edema Therapy: A Longitudinal Study

Alterations of outer retinal reflectivity in diabetic patients without clinically detectable retinopathy

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