Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Gou, Dongzhi; Deng, Jiao-Yun; Tang, Qi-Ping; Lu, Jiajia; Bao, Li; Liu, Yiyun; Pei, De-Sheng

doi:10.1039/d4en00495g

Environ. Sci.: Nano

2024

DOI: 10.1039/d4en00495g

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Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Dongzhi Gou,

Jiao-Yun Deng,

Qi-Ping Tang

et al.

Abstract: Research on the impact of nanoplastics (NPs) on hematological and circulatory systems is currently limited. This study aimed to underscore the critical health risks associated with NPs in these systems...

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MoS₂ Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification

Zou,

Chang,

Zhang

et al. 2024

Environ. Sci. Technol.

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The widespread applications of molybdenum disulfide (MoS 2 ) nanosheets inevitably result in their release into aquatic environments, necessitating an exploration of their potential toxic effects on aquatic organisms. This study analyzes the cardiac responses of zebrafish larvae exposed to MoS 2 , with a focus on the influence of size and surface modifications. At higher concentrations (1 and 5 mg/L), MoS 2 nanosheets hampered larval growth without influencing cardiomyogenesis. At lower doses (0.5−100 μg/L), small-sized MoS 2 (ssMoS 2 , 187.2 nm) significantly impaired cardiac development, as proved by morphology abnormality, decreased heartbeat, stroke volume, and cardiac output, whereas these undesirable changes were not observed in the cysteine-modified form. Large-sized nanosheets (1.638 μm) did not localize to the heart, barely showing a cardiac disorder. Transcriptomics, biochemical analysis, and computational simulation validated that ssMoS 2 aggravated Fe 2+ overload through excessive ferritinophagy and ferroportin-1 inhibition, accompanied by down-regulation of glutathione peroxidase 4 and activation of PUFAs esterification, leading to ferroptosis. Significant associations between ferroptosis signals and cardiac indices, along with the ferrostatin-1 inhibition test, confirmed the ferroptosis-mediated cardiotoxicity of ssMoS 2 . Our study provides a key understanding of molecular events underlying MoS 2 -induced cardiotoxicity and highlights the importance of size and surface characteristics, which are significant for risk assessment and the safe design of nanoproducts.

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MoS₂ Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification

Zou,

Chang,

Zhang

et al. 2024

Environ. Sci. Technol.

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Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Abstract: Research on the impact of nanoplastics (NPs) on hematological and circulatory systems is currently limited. This study aimed to underscore the critical health risks associated with NPs in these systems...

Cited by 1 publication

References 69 publications

MoS₂ Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification

MoS₂ Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification

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Elucidating the underlying toxic mechanisms of nanoplastics on zebrafish hematological and circulatory systems

Abstract: Research on the impact of nanoplastics (NPs) on hematological and circulatory systems is currently limited. This study aimed to underscore the critical health risks associated with NPs in these systems...

Cited by 1 publication

References 69 publications

MoS2 Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification

MoS2 Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification

Contact Info

Product

Resources

About

MoS₂ Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification

MoS₂ Nanosheets at Low Doses Induced Cardiotoxicity in Developing Zebrafish via Ferroptosis: Influence of Lateral Size and Surface Modification