Elucidation of Independently Modulated Genes in Streptococcus Pyogenes Reveals Carbon Sources that Control its Expression of Hemolytic Toxins

Hirose, Yujiro; Poudel, Saugat; Sastry, Anand V.; Rychel, Kevin; Szubin, Richard; Zielinski, Daniel C.; Lim, Hyun Gyu; Menon, Nitasha D.; Bergsten, Helena; Uchiyama, Satoshi; Hanada, Takeshi; Kawabata, Shigetada; Palsson, Bernhard Ø.; Nizet, Victor

doi:10.2139/ssrn.4260497

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2024

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“…For example, ICA of Vibrio natriegens transcriptomes unveils the genetic basis of its natural competency (Shin et al., 2023). ICA has also been used to discover therapeutic strategies for Streptococcus pyogenes by identifying carbon sources that control the expression of haemolytic toxins (Hirose et al., 2023).…”

Section: Introductionmentioning

confidence: 99%

Systematic elucidation of independently modulated genes in Lactiplantibacillus plantarum reveals a trade‐off between secondary and primary metabolism

Qiu,

Huang,

Liang

et al. 2024

Microbial Biotechnology

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Lactiplantibacillus plantarum is a probiotic bacterium widely used in food and health industries, but its gene regulatory information is limited in existing databases, which impedes the research of its physiology and its applications. To obtain a better understanding of the transcriptional regulatory network of L. plantarum, independent component analysis of its transcriptomes was used to derive 45 sets of independently modulated genes (iModulons). Those iModulons were annotated for associated transcription factors and functional pathways, and active iModulons in response to different growth conditions were identified and characterized in detail. Eventually, the analysis of iModulon activities reveals a trade‐off between regulatory activities of secondary and primary metabolism in L. plantarum.

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Section: Introductionmentioning

confidence: 99%