Embolization using warmed glue via the triaxial microballoon occlusion system for various vascular disorders

Mine, Takahiko; Ueda, Tatsuo; Yasui, Daisuke; Mizushima, Shohei; Kumita, Shin‐ichiro

doi:10.5152/dir.2019.19285

Cited by 4 publications

(11 citation statements)

References 6 publications

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“…N -butyl cyanoacrylate (NBCA) provides secure vessel occlusion due to its strong adhesive property [ 1 – 3 ]. The mixture of NBCA and iodized oil, which imparts radiopacity and viscosity, has been used in endovascular embolization for various vascular disorders, including cerebral or peripheral arteriovenous malformations [ 1 , 2 , 4 ], traumatic and other sources of idiopathic bleeding [ 3 , 5 – 7 ], and aortic intervention-related embolization [ 3 , 8 ]. Meanwhile, inadequate distribution of the mixture can cause unexpected organ damage [ 1 – 3 , 5 – 7 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The mixture of NBCA and iodized oil, which imparts radiopacity and viscosity, has been used in endovascular embolization for various vascular disorders, including cerebral or peripheral arteriovenous malformations [ 1 , 2 , 4 ], traumatic and other sources of idiopathic bleeding [ 3 , 5 – 7 ], and aortic intervention-related embolization [ 3 , 8 ]. Meanwhile, inadequate distribution of the mixture can cause unexpected organ damage [ 1 – 3 , 5 – 7 , 9 , 10 ]. The extent of the mixture within the vasculature depends upon various factors, including blood flow velocity, vessel anatomy, mixture viscosity, polymerization time, and injection method [ 1 – 3 , 7 , 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, inadequate distribution of the mixture can cause unexpected organ damage [ 1 – 3 , 5 – 7 , 9 , 10 ]. The extent of the mixture within the vasculature depends upon various factors, including blood flow velocity, vessel anatomy, mixture viscosity, polymerization time, and injection method [ 1 – 3 , 7 , 9 – 11 ]. The relation between polymerization time and mixture ratio has been detailed so far [ 1 , 11 ], and the modification of instruments or preparations to gain better handling of the mixture has also been reported.…”

Section: Introductionmentioning

confidence: 99%

“…The relation between polymerization time and mixture ratio has been detailed so far [ 1 , 11 ], and the modification of instruments or preparations to gain better handling of the mixture has also been reported. The blood flow control method using a microballoon catheter, an instrumental technique, is known to efficiently control the extent of the mixture [ 3 , 7 , 9 ]. Further, mixing NBCA with glacial acetic acid or ethanol, a preparation technique, modified the adhesive property of the material and achieved a slow and high amount of infusion [ 2 , 8 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further, mixing NBCA with glacial acetic acid or ethanol, a preparation technique, modified the adhesive property of the material and achieved a slow and high amount of infusion [ 2 , 8 , 12 ]. Studies regarding temperature alteration addressed its effect on the mixture viscosity and the polymerization time [ 3 , 13 , 14 ], though the previously evaluated temperature range was limited and a more detailed study may help in better handling of the NBCA-iodized oil mixtures for lesions requiring peripheral delivery.…”

Section: Introductionmentioning

confidence: 99%

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Effects of temperature alteration on viscosity, polymerization, and in-vivo arterial distribution of N-butyl cyanoacrylate-iodized oil mixtures

et al. 2021

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Purpose Temperature alteration can modify the polymerization of n-butyl cyanoacrylate (NBCA)-iodized oil mixtures during vascular embolization; its effects on viscosity, polymerization time, and intra-arterial distribution of the NBCA-iodized oil mixture were investigated. Materials and methods In vitro, the viscosities of NBCA, iodized oil, and NBCA-iodized oil mixtures (ratio, 1:1–8) were measured at 4–60 ºC using a rotational rheometer. The polymerization times (from contact with blood plasma to stasis) were recorded at 0–60 ºC using a high-speed video camera. In vivo, the 1:2 mixture was injected into rabbit renal arteries at 0, 20, and 60 ºC; intra-arterial distribution of the mixture was pathologically evaluated. Results The mixtures’ viscosities decreased as temperature increased; those at 60 ºC were almost four to five times lower than those at 4 ºC. The polymerization time of NBCA and the 1:1–4 mixtures increased as temperature decreased in the 0–30 ºC range; the degree of time prolongation increased as the percentage of iodized oil decreased. The 0 ºC group demonstrated distributions of the mixture within more peripheral arterial branches than the 20 and 60 ºC groups. Conclusion Warming reduces the mixture’s viscosity; cooling prolongs polymerization. Both can be potential factors to improve the handling of NBCA-iodized oil mixtures for lesions requiring peripheral delivery. Secondary abstract Temperature alteration influences the polymerization time, viscosity, and intra-arterial distribution of NBCA-iodized oil mixtures. Warming reduces the viscosity of the mixture, while cooling prolongs polymerization.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of temperature alteration on viscosity, polymerization, and in-vivo arterial distribution of N-butyl cyanoacrylate-iodized oil mixtures

et al. 2021

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An Alternative Endovascular Technique for Treatment of Pulmonary Arteriovenous Malformation: Microballoon-occluded Transcatheter Embolization Using n-butyl-2-cyanoacrylate

Chu,

Kim,

Gwon

2024

Cardiovasc Intervent Radiol

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Inadvertent accident during balloon-occluded glue injection for facial AVM: rescue procedure using intentional glue injection

Hong

Guen

2022

CVIR Endovasc

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Background Glue embolization during balloon inflation is a novel technique with many advantages. However, the procedure’s major complication is the adhesion of the balloon catheter by glue. Several studies have reported strategies to prevent this. However, no reports have described a rescue method after accidental adhesion occurs. Case presentation A 26-year-old male was referred to the department of interventional radiology for sclerotherapy of an aggravating large facial arteriovenous malformation (AVM). We planned a transvenous approach to decrease the velocity of AVM and increase the efficacy of the sclerotherapy treatment. We performed glue embolization of a major draining vein during microballoon inflation. Upon injection of the glue, inadvertent glue reflux occurred, and the microballoon was stuck to the vessel wall. While removing the microballoon catheter, its shaft broke in the guiding catheter. We filled the inner lumen of the guiding catheter with glue and waited for polymerization to fixate the broken microballoon catheter inside the guiding catheter. Fortunately, the stuck microballoon was separated, and two broken pieces of microballoon catheter were removed through femoral vein short sheath. Conclusion Intentional glue casting in the outer catheter is very useful when removing anything that is inside the catheter or stuck due to the glue reflux. It can be applied to various similar emergency situations.

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Embolization using warmed glue via the triaxial microballoon occlusion system for various vascular disorders

Cited by 4 publications

References 6 publications

Effects of temperature alteration on viscosity, polymerization, and in-vivo arterial distribution of N-butyl cyanoacrylate-iodized oil mixtures

Effects of temperature alteration on viscosity, polymerization, and in-vivo arterial distribution of N-butyl cyanoacrylate-iodized oil mixtures

An Alternative Endovascular Technique for Treatment of Pulmonary Arteriovenous Malformation: Microballoon-occluded Transcatheter Embolization Using n-butyl-2-cyanoacrylate

Inadvertent accident during balloon-occluded glue injection for facial AVM: rescue procedure using intentional glue injection

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