Embrace the Machine: A Risk Factor-based Machine Learning Approach to Target Breast Skin Necrosis

Abstract

significant increases in textured and smooth groups when compared to no implant. In the biomimetic platform, SUPM2 had a higher rate of proliferation when compared to collagen only, which was not significant between groups. TLBR2 exposed to low serum media appeared to have a higher rate of cell proliferation in groups exposed to no implant (p>0.05). In full serum media, all cell lines demonstrated increased proliferation over time with no significant difference between groups. CONCLUSION:When cultured in a 3D breast biomimetic platform, BIA-ALCL cells proliferate within a simulated breast microenvironment even without the addition of growth factors, while limited or decreased proliferation is seen when cultured in the same ECM without such cellular components. We have shown a difference in the cell proliferation trends that occur when different ALCL lines are cultured in 2-dimensions (media only) versus 3-dimensions (collagen embedded), emphasizing the physiologic relevance of our 3-dimensional model.