PurposeThis study aims to explore the effect of human resource (HR) strategy (e.g. empowerment and teamwork) on green supply chain integration (e.g. green supplier and customer integration), which further leads to economic performance. Moreover, the authors examined the moderating effects of information systems and mutual trust on the relationship between HR strategy and green supply chain integration.Design/methodology/approachUsing the empirical data from 213 Chinese manufacturing firms, this study uses structural equation modeling and hierarchical regressions to examine the conceptual model.FindingsThe study’s findings reveal that empowerment and teamwork positively enhance green supplier and customer integration. Green supplier and customer integration are positively related to economic performance. Moreover, information systems positively moderate the relationship between empowerment and green supplier integration but negatively moderate the relationship between teamwork and green supplier/customer integration. Mutual trust positively moderates the relationship between empowerment and green supplier integration and the relationship between teamwork and green customer integration.Originality/valueThis study extends the existing understanding regarding how to enhance green supply chain integration by adopting an appropriate HR strategy in the context of different levels of information systems and mutual trust.