Embryo quality is the main factor affecting cumulative live birth rate after elective single embryo transfer in fresh stimulation cycles

Niinimäki, Maarit; Veleva, Zdravka; Martikainen, Hannu

doi:10.1016/j.ejogrb.2015.08.031

Cited by 21 publications

(20 citation statements)

References 19 publications

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“…This finding was also reported by our group in a large retrospective analysis of 70,968 cycles, where those with the highest oocyte yield had the lowest blastulation rates [11]. Oocytes are, of course, essential in the formation of blastocysts for successful IVF cycles, but it is increasingly being recognized that a greater number of oocytes retrieved may not necessarily be associated with the best IVF outcomes [12,[14][15][16][17][18]21]. It has been suggested that the optimal number of oocytes retrieved in a cycle may depend on the exact stimulation protocol and that a lower number of oocytes retrieved is not necessarily correlated with poorer IVF outcomes [12,15,17,22].…”

Section: Discussionsupporting

confidence: 77%

“…Oocytes are, of course, essential in the formation of blastocysts for successful IVF cycles, but it is increasingly being recognized that a greater number of oocytes retrieved may not necessarily be associated with the best IVF outcomes [12,[14][15][16][17][18]21]. It has been suggested that the optimal number of oocytes retrieved in a cycle may depend on the exact stimulation protocol and that a lower number of oocytes retrieved is not necessarily correlated with poorer IVF outcomes [12,15,17,22]. This data suggests that an emphasis on embryo quality over oocyte quantity may be a more appropriate strategy for the management of IVF cycles.…”

Section: Discussionmentioning

confidence: 99%

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Patient and in vitro fertilization (IVF) cycle characteristics associated with variable blastulation rates: a retrospective study from the Duke Fertility Center (2013–2017)

Jones

Acharya

et al. 2019

Middle East Fertil Soc J

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Background: To evaluate the association of patient and IVF cycle characteristics with blastulation rate and formation of high-quality blastocysts Results: We analyzed autologous blastocyst cycles from 2013 to 2017. Cycles were subdivided into low (< 33%), intermediate (33-66%), and high (> 66%) blastulation rates. Embryo quality was assigned by embryologists using Gardner Criteria. R statistical package was used, and the blastulation groups were compared using analysis of variance (ANOVA) for continuous variables and chi-squared tests for categorical variables. The Bonferroni correction was used to adjust for multiple comparisons. One hundred seventeen IVF cycles met our inclusion criteria. Of these, 20 (17.1%) had low, 74 (63.2%) had intermediate, and 23 (19.7%) had high blastulation rates. Low blastulation rate was associated with a lower number of blastocysts, including fewer high-quality blastocysts. The mean number of oocytes retrieved was highest (18.1) in the group with the lowest blastulation rate, and lowest (13.4) in those with the highest blastulation rate, although this did not reach statistical significance. There were no significant differences between blastulation rates and age, gravidity, prior live birth, anti-mullerian hormone, estradiol and progesterone levels on the day of ovulation trigger, follicle-stimulating hormone dose, or fertility diagnosis. Conclusions: High blastulation rate is associated with a greater number of blastocysts, including a greater number of high-quality blastocysts. Higher oocyte yield, however, is not associated with improved blastulation rates. Blastulation rates, blastocyst number, and quality remain difficult to predict based on cycle characteristics alone, and oocyte yield may not be an accurate predictor of either outcome. Precis High oocyte yield may be associated with a lower blastulation rate and a lower number of high-quality blastocysts.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Patient and in vitro fertilization (IVF) cycle characteristics associated with variable blastulation rates: a retrospective study from the Duke Fertility Center (2013–2017)

Jones

Acharya

et al. 2019

Middle East Fertil Soc J

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“…The main goal in assisted reproductive technology (ART) is achieving a healthy singleton live birth. There are several factors that can affect ART outcome, namely the quality of embryos developed in vitro [1][2][3]. Embryo morphology is a noninvasive selection method that can be easily adopted in an in vitro fertilization (IVF) laboratory for choosing embryos for embryo transfer (ET) [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure of cytoplasmic fragments in human cleavage stage embryos

Halvaei

Khalili

Esfandiari

et al. 2016

J Assist Reprod Genet

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“…The outcome of in-vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) is affected by various factors, of which embryo quality is one of the most important prognostic factors for pregnancy chance [1]. Good quality embryos have higher implantation potential, thus, resulting in higher pregnancy chance.…”

Section: Introductionmentioning

confidence: 99%

Reasons for no good embryos in the IVF/ICSI cycle: A retrospective analysis.

Chu¹,

Shu²,

Zhang³

et al. 2019

Preprint

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Background: The aim of this study was to clarify related factors of no good quality embryos in IVF/ICSI cycle so as to improve the IVF/ICSI outcome. Methods: Data of Day 3 embryos and patients of 2518 cycles from January 2012 to December 2016 were analyzed in this study. A binary logistic regression model was conducted to examine the factors which led to no good quality embryo in one cycle.Results: The incidence of no good quality embryo in one cycle was 13.3%. Number of oocytes, fertilization methods, stimulation protocol, and fertilization rate were significant in logistic regression analysis. Further analysis showed significant correlations between increasing intracellular fragmentation and the following parameters: number of oocytes, fertilization rate, and infertility diagnosis; slow growing embryos: number of oocytes, fertilization rate, and fertilization methods; embryos with asymmetric cleavage: number of oocytes, fertilization rate, fertilization methods, female age, and male age; compound causes: number of oocytes, fertilization rate, infertility duration, stimulation protocol, and fertilization methods.Conclusions: The results suggested that gamete poor quality is the main reason for the embryo quality decline, which underlines the importance to improve gamete quality and eventually the fertility outcome in clinical practice.

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Embryo quality is the main factor affecting cumulative live birth rate after elective single embryo transfer in fresh stimulation cycles

Cited by 21 publications

References 19 publications

Patient and in vitro fertilization (IVF) cycle characteristics associated with variable blastulation rates: a retrospective study from the Duke Fertility Center (2013–2017)

Patient and in vitro fertilization (IVF) cycle characteristics associated with variable blastulation rates: a retrospective study from the Duke Fertility Center (2013–2017)

Ultrastructure of cytoplasmic fragments in human cleavage stage embryos

Reasons for no good embryos in the IVF/ICSI cycle: A retrospective analysis.

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