Embryonic and postnatal development of calcium-binding proteins immunoreactivity in the anterior thalamus of the guinea pig

Żakowski, Witold; Bogus‐Nowakowska, Krystyna; Robak, Anna

doi:10.1016/j.jchemneu.2013.09.005

Cited by 12 publications

(6 citation statements)

References 64 publications

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“…In guinea pigs at P20, PV immuno-staining of the anterior thalamic nuclei showed more abundant PV+ nerve terminals in the AD than in the AV and AM. 21 These findings indicate a typical distribution pattern of PV in rodent anterior thalamic nuclei. 22 The morphology of time-specific nodular nerve terminals in P14 are similar to TRN-derived GABA-positive nerve terminals distributed in the ventral basal nuclei of rats observed by 3 weeks of age.…”

Section: Discussionsupporting

confidence: 56%

“…25 Thus, the reason that the projections from the TRN to the AD and the AD projections to the cortex are already established by P14 is probably that the HD system immediately utilizes the visual information carried by these projections. 13,25 As some visual input to the AD comes from other cortical areas 20,21 and some come directly from the retina, 26 these projections may be completed early on to adequately process information from such pathways. In addition to this input to the AD, it is known to receive projections from the mammillary body.…”

Section: Discussionmentioning

confidence: 99%

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Postnatal development of thalamic reticular nucleus projections to the anterior thalamic nuclei in rats

et al. 2022

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The thalamic reticular nucleus (TRN) projects inhibitory signals to the thalamus, thereby controlling thalamocortical connections. Few studies have examined the development of TRN projections to the anterior thalamic nuclei with regard to axon course and the axon terminal distributions. In the present study, we used parvalbumin (PV) immunostaining to investigate inhibitory projections from the TRN to the thalamus in postnatal (P) 2- to 5-week-old rats (P14–35). The distribution of PV-positive (+) nerve fibers and nerve terminals markedly differed among the anterior thalamic nuclei at P14. Small, beaded nerve terminals were more distributed throughout the anterodorsal nucleus (AD) than in the anteroventral nucleus (AV) and anteromedial nucleus (AM). PV+ fibers traveling from the TRN to the AD were observed in the AV and AM. Nodular nerve terminals, spindle or en passant terminals, were identified on the axons passing through the AV and AM. At P21, axon bundles traveling without nodular terminals were observed, and nerve terminals were distributed throughout the AV and AM similar to the AD. At P28 and P35, the nerve terminals were evenly distributed throughout each nucleus. In addition, DiI tracer injections into the retrosplenial cortex revealed retrogradely-labeled projection neurons in the 3 nuclei at P14. At P14, the AD received abundant projections from the TRN and then projected to the retrosplenial cortex. The AV and AM seem to receive projections with distinct nodular nerve terminals from the TRN and project to the retrosplenial cortex. The projections from TRN to the AV and AM with nodular nerve terminals at P14 are probably developmental-period specific. In comparison, the TRN projections to the AD at P14 might be related to the development of spatial navigation as part of the head orientation system.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Postnatal development of thalamic reticular nucleus projections to the anterior thalamic nuclei in rats

et al. 2022

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“…Although calcium-binding protein expressing neurons are thought to largely comprise distinct neuronal populations, it is possible that these proteins are co-expressed in some anterior thalamic neurons. In support of this, neuronal co-expression of these proteins has been reported in the human visual and temporal cortex regions (del Río and DeFelipe, 1997, Leuba and Saini, 1997) and in the anterior thalamus of guinea pigs (Zakowski et al, 2013). We were not able to assess colocalization in the current study, however, the total proportion of calcium-binding protein positive neurons was greater than one among control samples but less than one among samples from people with Down syndrome.…”

Section: Discussionmentioning

confidence: 57%

Reduction in neurons immunoreactive for parvalbumin, calretinin and calbindin in the anteroventral thalamic nuclei of individuals with Down syndrome

Perry,

Vann

2024

Preprint

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The anterior thalamic nuclei are important for cognition, and memory in particular. However, little is known about how the anterior thalamic nuclei are affected in many neurological disorders partly due to difficulties in selective segmentation in in vivo scans, due to their size and location. Post-mortem studies, therefore, remain a valuable source of information about the status of the anterior thalamic nuclei. We used post-mortem tissue to assess the status of the anteroventral thalamic nucleus in Down syndrome using samples from males and females ranging from 22-65 years in age and comparing to tissue from age matched controls. As expected, there was increased beta-amyloid plaque expression in the Down syndrome group. While there was a significant increase in neuronal density in the Down syndrome group, the values showed more variation consistent with a heterogeneous population. The surface area of the anteroventral thalamic nucleus was smaller in the Down syndrome group suggesting the increased neuronal density was due to greater neuronal packing but likely fewer overall neurons. There was a marked reduction in the proportion of neurons immunoreactive for the calcium-binding proteins calbindin, calretinin, and parvalbumin in individuals with Down syndrome across all ages. These findings highlight the vulnerability of calcium-binding proteins in the anteroventral nucleus in Down syndrome, which could both be driven by, and exacerbate, Alzheimer-related pathology in this region.

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“…) while moderate to low in the guinea pig's POA (present results), it may be due to the various methods used for the detection of GalR2 or may be species related. The guinea pig is an unusual rodent in the aspect of brain morphology and neurochemistry (Żakowski and Robak, ; Żakowski et al., ) as well as in the aspect of reproduction and has some features very similar to humans (for review, see Mitchell and Taggart, ; Everett, ). For example, during pregnancy for the first source of progesterone is corpus luteum, followed by is placenta, while for the rat, mouse and rabbit, the corpus luteum is the only source of progesterone.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Galanin and Galanin Receptor 2 in the Pre‐optic Area of the Female Guinea Pig

Hermanowicz

Bogus‐Nowakowska

Równiak

et al. 2014

Anat Histol Embryol

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This study describes the distribution of galanin (Gal) and galanin receptor 2 (GalR2) in the pre-optic area (POA) of the female guinea pig. Frozen sections were undergone for a routine immunofluorescence labelling. Gal and GalR2 display immunoreactivity in all parts of the pre-optic area. Gal shows reactivity both in perikarya and fibres, whereas GalR2 was observed only in perikarya. Gal- and GalR2-immunoreactive (-ir) perikarya were the most numerous in the medial pre-optic area (MPA) with the highest reactivity in its dorsal part. In the median pre-optic nucleus (MPN) and periventricular pre-optic nucleus (PPN), only single Gal- and GalR2-ir neurons were observed. The highest density of Gal-ir fibres was revealed in the PPN and the lowest in the lateral pre-optic area (LPA). The results of this study indicate that the distribution pattern of Gal containing neurons overlaps well with the distribution pattern of GalR2-positive neurons, especially in the MPA. This may suggest GalR2-dependent activity in this brain region.

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Embryonic and postnatal development of calcium-binding proteins immunoreactivity in the anterior thalamus of the guinea pig

Cited by 12 publications

References 64 publications

Postnatal development of thalamic reticular nucleus projections to the anterior thalamic nuclei in rats

Postnatal development of thalamic reticular nucleus projections to the anterior thalamic nuclei in rats

Reduction in neurons immunoreactive for parvalbumin, calretinin and calbindin in the anteroventral thalamic nuclei of individuals with Down syndrome

Distribution of Galanin and Galanin Receptor 2 in the Pre‐optic Area of the Female Guinea Pig

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