2011
DOI: 10.1242/dmm.006494
|View full text |Cite
|
Sign up to set email alerts
|

Embryonic frog epidermis: a model for the study of cell-cell interactions in the development of mucociliary disease

Abstract: SUMMARYSpecialised epithelia such as mucociliary, secretory and transporting epithelia line all major organs, including the lung, gut and kidney. Malfunction of these epithelia is associated with many human diseases. The frog embryonic epidermis possesses mucus-secreting and multiciliated cells, and has served as an excellent model system for the biogenesis of cilia. However, ionic regulation is important for the function of all specialised epithelia and it is not clear how this is achieved in the embryonic fr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
100
0

Year Published

2011
2011
2019
2019

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 87 publications
(102 citation statements)
references
References 66 publications
2
100
0
Order By: Relevance
“…1c). In the Xenopus epidermis, four types of cells, alpha-ionocytes, betaionocytes, small secretory cells and MCCs, are distributed in a salt-and-pepper pattern [14][15][16][17][18][19] . MCCs bear many cilia on their surface, and therefore, they can be detected by immunostaining with an antibody against acetylated a-tubulin (a marker of cilia).…”
Section: Expression Patterns Of Erk7 During Xenopus Developmentmentioning
confidence: 99%
“…1c). In the Xenopus epidermis, four types of cells, alpha-ionocytes, betaionocytes, small secretory cells and MCCs, are distributed in a salt-and-pepper pattern [14][15][16][17][18][19] . MCCs bear many cilia on their surface, and therefore, they can be detected by immunostaining with an antibody against acetylated a-tubulin (a marker of cilia).…”
Section: Expression Patterns Of Erk7 During Xenopus Developmentmentioning
confidence: 99%
“…The Xenopus embryonic epithelium has been used as a model system to understand epithelial cell specification as it contains MCCs, ionocytes and mucus-secreting goblet cells 7,21,22 . During our screen identifying genes that show a characteristic expression pattern in the embryonic epithelium, we found that an evolutionarily conserved gene, mab21-l3, showed a salt-andpepper pattern of expression (see below).…”
Section: Xenopus Mab21-l3 Is Expressed In Both Mccs and A-ionocytesmentioning
confidence: 99%
“…The expression was first detected in the presumptive ectoderm in the animal region at the early gastrula stage (stage 10.5), and became restricted to the ventral ectoderm with a spotted pattern at the late gastrula stage (stage 12/13). At neurula and tailbud stages (stage [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], mab21-l3 is expressed in the epidermis with a salt-and-pepper pattern.…”
Section: Xenopus Mab21-l3 Is Expressed In Both Mccs and A-ionocytesmentioning
confidence: 99%
See 2 more Smart Citations