Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

Wang, Yanwen; Wang, Mengjing; Zhang, Hong; Zhao, Conghui; Zhang, Yaping; He, Guimei; Cui, Pengfei; Li, Yubao; Liu, Wenqiang; Shen, Jinyan; Sun, Xiaohong; Wang, Wenting; Zeng, Xianying; Li, Yanbing; Chu, Dong; Peng, Peng; Guo, Jing; Chen, Hualan; Li, Xuyong

doi:10.1128/spectrum.00807-22

Cited by 15 publications

(14 citation statements)

References 58 publications

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“…The YRD wetland located in Eastern China is an important habitat for migratory birds on the East Asian-Australasian (EAA) flyway. We have identified 28 subtypes of AIVs in wild birds in YRD wetland from 2017 to 2022, as shown in our previous studies [8,9,[30][31][32][33][34][35]. In this study, we fully uncovered the ecology and evolutionary dynamics of the globally identified H12 viruses.…”

Section: Introductionsupporting

confidence: 56%

Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China

Wang,

Guo,

Zhang

et al. 2024

Transboundary and Emerging Diseases

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Wild migratory birds are considered the central reservoirs of avian influenza viruses. H12 viruses are one of the 16 hemagglutinin (HA) subtypes of avian influenza viruses and are rarely reported because they are infrequently detected in birds. Consequently, the ecological and genetic profiles of H12 viruses and their adaptation in domestic birds and mammals remain unclear. Here, we found that H12N5 viruses were predominant in the nine identified H12NX subtypes, with the HA (H12) and neuraminidase (NA) (N5) genes showing combination bias in the categorized analysis of subtype combinations (H12 and N1–N9; H1–H12, H14, H15, and N5). These identified H12N5 viruses were primarily detected in birds of Anatidae and Scolopacidae in North America, excluding their possible characterization as chicken or mammalian viruses. The H12N5 viruses were divided into the North American lineage and Eurasian lineage according to their genetic differences, including the HA and NA surface genes and internal genes, although reassortment was observed between the two lineages. We isolated an Eurasian-lineage H12N5 virus from wild ducks in Eastern China, which was one of the 12 identified H12 viruses in China. Infectivity studies indicated that the H12N5 virus is poorly adapted to domestic ducks and chickens, although viral shedding could be detected in both inoculated and contact birds. Additionally, the naturally isolated H12N5 virus did not achieve good replication in mice. These results indicate that the rare subtype of H12 viruses was mainly pooled in wild migratory birds and has an established phylogeography, with low risks of spillover into domestic birds and mammals.

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Section: Introductionsupporting

confidence: 56%

Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China

Wang,

Guo,

Zhang

et al. 2024

Transboundary and Emerging Diseases

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“…demonstrated that the acquisition of PB2 627K in mammals is driven by the low polymerase activity attributed to PA. 49 Moreover, Bhat et al showed that acquiring the PA gene from an H9N2 virus dramatically increased the polymerase activity of an H7N9 virus in human cells. 50 In terms of the rapid evolution and active reassortment of H10N3 in nature, 23,40,41 the presence of avian adaptation marker PB2 627E does not downgrade the potential cross-species transmission of H10N3 viruses.…”

Section: Discussionmentioning

confidence: 99%

“…H10N8 viruses caused three human infections between 2013 and 2014; however, no additional H10N8 human case was reported thereafter. Then, in 2021, an H10N3 human case was reported in Jiangsu, China, raising the concern of cross‐species transmission of H10 virus 10,21–23 . This case raised questions as to how the H10N3 virus has evolved to infect humans since 2014, and how much risk do H10N3 viruses pose to the poultry industry and public health.…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021

Zhang

Shi

Cui

et al. 2023

Journal of Medical Virology

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The H10 subtypes of avian influenza viruses pose a continual threat to the poultry industry and human health. The sporadic spillover of H10 subtypes viruses from poultry to humans is represented by the H10N8 human cases in 2013 and the recent H10N3 human infection in 2021. However, the genesis and characteristics of the recent reassortment H10N3 viruses have not been systemically investigated. In this study, we characterized 20 H10N3 viruses isolated in live poultry markets during routine nationwide surveillance in China from 2014 to 2021. The viruses in the recent reassortant genotype acquired their hemagglutinin (HA) and neuraminidase (NA) genes from the duck H10 viruses and H7N3 viruses, respectively, whereas the internal genes were derived from chicken H9N2 viruses as early as 2019. Receptorbinding analysis indicated that two of the tested H10N3 viruses had a higher affinity for human-type receptors than for avian-type receptors, highlighting the potential risk of avian-to-human transmission. Animal studies showed that only viruses belonging to the recent reassortant genotype were pathogenic in mice; two tested viruses transmitted via direct contact and one virus transmitted by respiratory droplets in guinea pigs, though with limited efficiency. These findings emphasize the need for enhanced surveillance of H10N3 viruses.

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“…Owing to the detection of rearrangements and mutations of the Influenza virus in wild birds, public concern about the potential pandemic risk posed by this viral species and its mutations is growing significantly ( 77 , 86 , 87 ). Indeed, evidence of transmission from avian viral species to humans has previously been described for A/H7N9, A/H6N1 and A/H10N8 variants, and approximately 35% of patients infected with A/H7N9 succumbed to zoonotic infection ( 87 ).…”

Section: Virus Reservoirs In Mammals and Birdsmentioning

confidence: 99%

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Pereira,

Diniz,

da Costa

et al. 2023

Front. Immunol.

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Normally, the host immunological response to viral infection is coordinated to restore homeostasis and protect the individual from possible tissue damage. The two major approaches are adopted by the host to deal with the pathogen: resistance or tolerance. The nature of the responses often differs between species and between individuals of the same species. Resistance includes innate and adaptive immune responses to control virus replication. Disease tolerance relies on the immune response allowing the coexistence of infections in the host with minimal or no clinical signs, while maintaining sufficient viral replication for transmission. Here, we compared the virome of bats, rodents and migratory birds and the molecular mechanisms underlying symptomatic and asymptomatic disease progression. We also explore the influence of the host physiology and environmental influences on RNA virus expression and how it impacts on the whole brain transcriptome of seemingly healthy semipalmated sandpiper (Calidris pusilla) and spotted sandpiper (Actitis macularius). Three time points throughout the year were selected to understand the importance of longitudinal surveys in the characterization of the virome. We finally revisited evidence that upstream and downstream regulation of the inflammatory response is, respectively, associated with resistance and tolerance to viral infections.

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Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

Abstract: The emerging avian influenza reassortants and mutants in birds pose an increasing threat to poultry and public health. H10 avian influenza viruses are widely prevalent in wild birds, poultry, seals, and minks and pose an increasing threat to human health.

Cited by 15 publications

References 58 publications

Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China

Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China

Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021

Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

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