Emergence in the functionalized carbon nanotubes as smart nanocarriers for drug delivery applications

ZnO/CNT@Fe 3 O 4 induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

“…In the present study, we used ZnO QD in combination with hydroxylated carbon nanotubes and Fe 3 O 4 in the form of ZnO/CNT@Fe 3 O 4 nanocomposite to increase water-solubility of our product. Previous studies have declared that owing to their excellent surface properties, CNT are smart nano-carries for the delivery of drugs, genes and other biomedically essential materials into the cells with high biocompatibility [16]. Apart from its inimitable cell penetration aptitude, CNTs have proven to be suitable in specific and targeted drug delivery to desired cancerous tissues [24].…”

“…Given to the low toxicity profile and the promising efficacy on malignant cells, it was interesting to combine Fe 3 O 4 and ZnO in the form of nanocomposites and to use the anti-cancer property of these two nanoparticles simultaneously. Based on low solubility of metal NPs in the liquid medium [15], we decided to use hydroxylated carbon nanotubes (CNT) as a soluble compound to make our nanocomposite completely water-soluble [16]. Of note, successful formation of ZnO/CNT@Fe 3 O 4 nanocomposite was further characterized using UV-spectroscopy, FTIR, SEM, and XRD.…”

Electroactive Smart Polymers for Biomedical Applications

“…The electric conductivity of many electroactive polymeric materials used is not high enough to achieve an effective modulation of drug release, leading to the use of more conducting materials (e.g., carbon-based nanomaterials) in polymeric networks as a strategy to enhance the electro-sensitivity of hydrogels. The addition of conductive particles such as CNT can improve the electrically stimulated drug delivery behavior of the intrinsic conductive polymers [115,116]. For instance, a semi-interpenetrating polymer network based on polyethylene oxide and pentaerythritol triacrylate polymers was prepared by electrospinning, and CNT was used to increase the electric sensitivity.…”

Functionalization of Carbon Nanomaterials for Biomedical Applications

“…Their high surface area and internal volume determines the high loading of drugs not only by the outer wall surface but also the internal cavity. Their 1D needle-like morphology facilitate CNT penetration through the cell membranes of targeted cells and the CNTs have already proven to have the capability to smartly deliver to desired sites after appropriate functionalization [200]. In 2007, Dai and coworkers reported the preparation of water-soluble phospholipid (PL)-PEG modified SWCNTs and loaded the DOX drug on them.…”