Emergence of Dengue Virus Serotype 2 Cosmopolitan Genotype, Brazil

Giovanetti, Marta; Pereira, Luiz Augusto; Santiago, Gilberto A.; Fonseca, Vagner; Mendoza, Maria C.B.; Oliveira, Carla de; Moraes, Laíse de; Xavier, Joilson; Tosta, Stephane; Fristch, Hegger; Barbosa, Emerson de Castro; Rodrigues, Evandra Strazza; Figueroa-Romero, Dana; Padilla‐Rojas, Carlos; Cáceres-Rey, Omar; Mendonça, Ana Flávia; Nogueira, Fernanda de Bruycker; Cunha, Rivaldo Venâncio da; Filippis, Ana María Bispo de; Freitas, Carla; Peterka, Cassio Roberto Leonel; Albuquerque, Carlos Frederico Campelo de; Franco, Leticia; Rico, Jairo Andrés Méndez; Muñoz‐Jordán, Jorge L.; Silva, Vinícius Lemes da; Alcântara, Luiz Carlos Júnior

doi:10.3201/eid2808.220550

Cited by 31 publications

(39 citation statements)

References 9 publications

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“…In areas of southern Asia, including Nepal 2017, Sri Lanka 2017–2018, Bangladesh 2017–2018, the Maldives 2017–2019, India 2021, and Pakistan 2022 [ 35 , 36 , 37 ], the cosmopolitan lineage C virus emerged, and this is where the lineage B (Indian) virus had previously circulated. Furthermore, the cosmopolitan lineage C virus spread for the first time to South America, with local transmission reported in Peru in 2019 [ 38 ] and Brazil in 2022 [ 39 ], both of which were mostly related to the Bangladesh 2017 virus [ 37 ]. It is possible that the cosmopolitan lineage C virus successfully adapted to humans, particularly in transmission fitness, resulting in its spread to a wider area and an increase in cases of infection.…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Dengue Virus Strains from the 2019–2020 Epidemic in Hanoi, Vietnam

Phadungsombat

Nguyen

et al. 2023

Microorganisms

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Dengue virus (DENV), which has circulated in Vietnam for several decades, has multiple serotypes and genotypes. A 2019 dengue outbreak resulted in a larger number of cases than any other outbreak. We conducted a molecular characterization using samples collected in 2019–2020 from dengue patients in Hanoi and nearby cities located in northern Vietnam. The circulating serotypes were DENV-1 (25%, n = 22) and DENV-2 (73%, n = 64). Phylogenetic analyses revealed that all DENV-1 (n = 13) were genotype I and clustered to local strains circulating during the previous outbreak in the 2017, whereas DENV-2 consisted of two genotypes: Asian-I (n = 5), related to local strains from 2006–2022, and cosmopolitan (n = 18), the predominant genotype in this epidemic. The current cosmopolitan virus was identified as having an Asian-Pacific lineage. The virus was closely related to strains in other recent outbreaks in Southeast Asian countries and China. Multiple introductions occurred in 2016–2017, which were possibly from maritime Southeast Asia (Indonesia, Singapore, and Malaysia), mainland Southeast Asia (Cambodia and Thailand), or China, rather than from an expansion of localized Vietnamese cosmopolitan strains that were previously detected in the 2000s. We also analyzed the genetic relationship between Vietnam’s cosmopolitan strain and recent global strains reported from Asia, Oceania, Africa, and South America. This analysis revealed that viruses of Asian-Pacific lineage are not restricted to Asia but have spread to Peru and Brazil in South America.

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Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Dengue Virus Strains from the 2019–2020 Epidemic in Hanoi, Vietnam

Phadungsombat

Nguyen

et al. 2023

Microorganisms

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“…5,8 In 2022, a cosmopolitan genotype (DENV-2 genotype II) was detected for the first time in Midwestern Brazil. 9 Although some Brazilian states have reported the DENV-2 cosmopolitan genotype, its incidence remains lower than DENV-1. There is still no circulation of this genotype in the Ribeirão Preto region; however, cases have been reported in other locations in São Paulo state and have shown a steady spread throughout the country.…”

Section: Close Monitoring Of Cryptically Circulating Denv Genotypes Inmentioning

confidence: 99%

DENV‐1 genotype V circulation during the nonepidemic period in the Northeast of São Paulo State endemic area

de La‐Roque,

Santos,

Oliveira

et al. 2024

Journal of Medical Virology

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To the Editor, Dengue virus (DENV), one of the most critical arboviruses, has caused extensive outbreaks in Latin America, particularly in Brazil. One of the lessons learned during the Covid-19 pandemic was that it is possible to establish real-time genomic surveillance to acquire information regarding the origin and spread of different viral variants. However, molecular surveillance of DENV genotypes during outbreaks or the prediction of their emergence remains a considerable challenge in the DENV epidemiology in Brazil. All four DENV serotypes (DENV-1-4) have been circulating in Brazil over the last 10 years. A systematic literature review showed that the predominant serotypes vary from region to region over a period. 1 Between 2000 and 2009, DENV-1-3 circulated simultaneously with the entry of DENV-4 in 2010. Since then, all serotypes have co-circulated. DENV-4 was the most prevalent serotype in 2012, particularly in the northern, northeastern, and southeastern regions. DENV-1 was dominant from 2014 to 2016, whereas DENV-2 was prevalent in 2018 in the entire country. 1

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“…albopictus mosquitoes (1), presenting frequent outbreaks with notable public health impact of both mild and severe dengue cases across the Americas, particularly over recent decades (2). DENV’s diversity encompasses four distinct antigenic serotypes (DENV-1 to DENV-4), which are frequently named according to their geographic origins, with a nucleotide variation of approximately 30% (3). Each serotype is additionally subdivided into distinct genotypes (3).…”

Section: The Studymentioning

confidence: 99%

“…DENV’s diversity encompasses four distinct antigenic serotypes (DENV-1 to DENV-4), which are frequently named according to their geographic origins, with a nucleotide variation of approximately 30% (3). Each serotype is additionally subdivided into distinct genotypes (3). Since the beginning of 2023, the Americas have been marked by numerous and substantial dengue epidemics, with nearly three million suspected and confirmed cases documented this year, surpassing the 2.8 million cases reported in 2022 (2).…”

Section: The Studymentioning

confidence: 99%

Genomics-based timely detection of Dengue Virus type I genotypes I and V in Uruguay

Morel,

Giovanetti,

Fonseca

et al. 2023

Preprint

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Emergence of Dengue Virus Serotype 2 Cosmopolitan Genotype, Brazil

Cited by 31 publications

References 9 publications

Molecular Characterization of Dengue Virus Strains from the 2019–2020 Epidemic in Hanoi, Vietnam

Molecular Characterization of Dengue Virus Strains from the 2019–2020 Epidemic in Hanoi, Vietnam

DENV‐1 genotype V circulation during the nonepidemic period in the Northeast of São Paulo State endemic area

Genomics-based timely detection of Dengue Virus type I genotypes I and V in Uruguay

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