Emergence of two distinct SARS-CoV-2 Gamma variants and the rapid spread of P.1-like-II SARS-CoV-2 during the second wave of COVID-19 in Santa Catarina, Southern Brazil

Padilha, Dayane Azevedo; Filho, Vilmar Benetti; Moreira, Renato Simões; Soratto, Tatiany Aparecida Teixeira; Maia, Guilherme Augusto; Christoff, Ana Paula; Barazzetti, Fernando Hartmann; Schörner, Marcos André; Ferrari, Fernanda; Martins, Carolina Leite; Kawagoe, Eric Kazuo; Wachter, Julia Kinetz; Sacchet, Paula; Baptistella, Antuani Rafael; Schlindwein, Aline Daiane; Coelho, Bruna Kellet; Fernandes, Sandra Biachini; Rovaris, Darcita Büerger; Anjos, Marlei Pickler Debiasi dos; Melo, Fernanda Roesene; Bittencourt, Bianca da Rosa; Cunha, Sthefani; Meneghetti, Karine Lena; Wendt, Nestor Cubas; Madaloz, Tâmela Zamboni; Rodrigues, Marcus Vinícius Duarte; Souza, Dóris Sobral Marques; Moraes, Milene Höehr de; Baptista, Rodrigo P.; Toledo-Silva, Guilherme; Razzera, Guilherme; Grisard, Edmundo C.; Stoco, Patrícia Hermes; Oliveira, Luiz Felipe Valter de; Bazzo, Maria Luiza; Fongaro, Gislaine; Wagner, Glauber

doi:10.1101/2022.01.13.22268697

Cited by 3 publications

(2 citation statements)

References 55 publications

(75 reference statements)

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“…Por fim, com foco na facilitação da visualização dos dados oriundos do sequenciamento, temos os mapas como antagonistas viáveis, além de exporem os pontos focais da doença, o que tornam os dados mais palatáveis até mesmo a leigos no assunto (Padilha et al, 2022).…”

Section: Coronavírusunclassified

Vigeai - Vigilância Epidemiológica Ambiental Integrativa - Laboratório De Virologia Aplicada Da Ufsc – Brasil: Bases Da Ferramenta Epidemiológica Para O Monitoramento Viral a Partir Do Esgoto Sanitário

Wachter¹,

Cadamuro²,

Savi³

et al. 2023

QUALIDADE DE VIDA: Da Saúde Humana À Saúde Ambiental

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O surgimento de patógenos ao longo da história evolutiva que utilizam vias ambientais de infecção/contaminação denotou a necessidade das ferramentas de monitoramento. Em meio a pandemia de COVID-19, causada pelo vírus SARS-CoV-2, a detecção do RNA viral no esgoto bruto tornou-se possível e útil como uma ferramenta epidemiológica, já que o vírus é excretado pelas fezes humanas. Métodos focados na detecção do RNA viral (técnicas baseadas em biologia molecular) e de partículas virais infecciosas (por cultura celular) foram utilizados para a detecção do SARS-CoV-2 em amostras de secreção de pacientes infectados. O monitoramento se mostra eficaz para compreender a circulação de vírus que utilizam rota fecal-oral, podendo antecipar futuros surtos em regiões específicas. Além disso, possibilita a observação das mutações e variantes em circulação num dado momento, através do sequenciamento. Este capítulo é um reporte das bases da ferramenta epidemiológica para o monitoramento viral em esgoto sanitário implementada pelo Laboratório de Virologia Aplicada da Universidade Federal de Santa Catarina, denominado “VigEAI” - Vigilância Epidemiológica Ambiental Integrativa.

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Section: Coronavírusunclassified

Vigeai - Vigilância Epidemiológica Ambiental Integrativa - Laboratório De Virologia Aplicada Da Ufsc – Brasil: Bases Da Ferramenta Epidemiológica Para O Monitoramento Viral a Partir Do Esgoto Sanitário

Wachter¹,

Cadamuro²,

Savi³

et al. 2023

QUALIDADE DE VIDA: Da Saúde Humana À Saúde Ambiental

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“…While this variant has also extended to other countries, especially those in South and Center America, the Gamma variant has become endemic in Brazil, especially in the State of Amazonas, where different Gamma Plus variants have been evolving. These variants harbor additional S protein mutations, making them more transmissible than the parental P.1 [ 93 , 94 , 95 ].…”

Section: Main Sars-cov-2 Variantsmentioning

confidence: 99%

Recapping the Features of SARS-CoV-2 and Its Main Variants: Status and Future Paths

Ortega

García-Montero

Fraile-Martínez

et al. 2022

JPM

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Over the two years that we have been experiencing the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic, our challenges have been the race to develop vaccines and the difficulties in fighting against new variants due to the rapid ability of the virus to evolve. In this sense, different organizations have identified and classified the different variants that have been emerging, distinguishing between variants of concern (VOC), variants of interest (VOI), or variants under monitoring (VUM). The following review aims to describe the latest updates focusing on VOC and already de-escalated variants, as well as to describe the impact these have had on the global situation. Understanding the intrinsic properties of SARS-CoV-2 and its interaction with the immune system and vaccination is essential to make out the underlying mechanisms that have led to the appearance of these variants, helping to determine the next steps for better public management of this pandemic.

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Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

Hoteit

Yassine

2022

Vaccines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million infections and more than 6 million deaths worldwide. Several vaccines have been produced and tested over the last two years. The SARS-CoV-2 virus, on the other hand, has mutated over time, resulting in genetic variation in the population of circulating variants during the COVID-19 pandemic. It has also shown immune-evading characteristics, suggesting that vaccinations against these variants could be potentially ineffective. The purpose of this review article is to investigate the key variants of concern (VOCs) and mutations of the virus driving the current pandemic, as well as to explore the transmission rates of SARS-CoV-2 VOCs in relation to epidemiological factors and to compare the virus’s transmission rate to that of prior coronaviruses. We examined and provided key information on SARS-CoV-2 VOCs in this study, including their transmissibility, infectivity rate, disease severity, affinity for angiotensin-converting enzyme 2 (ACE2) receptors, viral load, reproduction number, vaccination effectiveness, and vaccine breakthrough.

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Emergence of two distinct SARS-CoV-2 Gamma variants and the rapid spread of P.1-like-II SARS-CoV-2 during the second wave of COVID-19 in Santa Catarina, Southern Brazil

Cited by 3 publications

References 55 publications

Vigeai - Vigilância Epidemiológica Ambiental Integrativa - Laboratório De Virologia Aplicada Da Ufsc – Brasil: Bases Da Ferramenta Epidemiológica Para O Monitoramento Viral a Partir Do Esgoto Sanitário

Vigeai - Vigilância Epidemiológica Ambiental Integrativa - Laboratório De Virologia Aplicada Da Ufsc – Brasil: Bases Da Ferramenta Epidemiológica Para O Monitoramento Viral a Partir Do Esgoto Sanitário

Recapping the Features of SARS-CoV-2 and Its Main Variants: Status and Future Paths

Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

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