Emergent “Bloody Diarrhea” Associated with the Use of Oral Cefdinir in Young Children: A Brief Report and Review of Literature

Okla, Souad Al; Prashanth, G; Kurbet, Santosh B; Attraqchi, Yahya Al; Asaad, Alhasan

doi:10.1016/j.jemermed.2022.12.026

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Several reports have shown that the Cefdinir-iron complex produces reddish stool. [3][4][5] Most of these cases involve a similar scenario of prescribing Cefdinir while the infant is taking either a multivitamin with iron or iron-fortified formula. However, this case highlighted other iron-containing formulations, and multivitamins, Unexpectedly, healthcare providers and pharmacists are still unaware of these possible innocuous side effects.…”

Section: Discussionmentioning

confidence: 99%

A colourful consequence: The curious case of cefdinir and iron-containing supplements interaction in pediatric otitis media treatment

Alotaibi,

AlOmeir

2024

JMAHS

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Otitis media (OM) is a common infection of the middle ear that often affects young children. Cefdinir, a third-generation cephalosporin, is commonly prescribed to effectively treat OM. However, when Cefdinir is co-administering with iron-containing formulations, it can potentially result in the appearance of bloody-coloured stool. We presented a 10-month-old male infant who was admitted to the emergency after experiencing reddish-coloured stool while on Cefdinir and a multivitamin-containing iron formulation three days prior to the visit. During the physical examination, all vital signs were normal, and blood tests revealed no abnormalities. Upon consultation with a drug information specialist, it was determined that the interaction between Cefdinir and iron was the likely cause, and parents were advised to discontinue the use of the antibiotic agent.

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Section: Discussionmentioning

confidence: 99%