Emerging Approach for the Application of Hibiscus sabdariffa Extract Ointment in the Superficial Burn Care

Abstract

Wound healing comprises organized events involving tissue repair and regeneration. The discovery of toll-like receptors (TLRs) sheds recent light on the mechanisms involved in initiating inflammatory responses throughout the healing cascades. Hibiscus sabdariffa (HS) components may exhibit a wound healing action, owing to their antioxidant and anti-inflammatory activities. This study was designed to investigate the early effects of HS loaded in an ointment base on wound healing, antioxidant, antimicrobial effects, burning intensity, and histopathological features on the rat burn model in comparison to the standard treatment, Iruxol® ointment. A burn injury model was used to evaluate the wound healing potency of the preparation. Rats were treated with ointments three times on the day of the induction of the burn. Findings revealed that the strong antioxidant properties of the HS-loaded ointment augmented the skin healing potential by stimulating biomarkers required for skin regeneration. HS repressed the burning-induced inflammation by the effective reduction in the levels of tumor necrosis factor α (TNF-α) and IL-6 through TLR4 protein inhibition. Topical HS downregulates transforming growth factor-beta (TGF-β) levels. HS extract possesses a potential bactericidal activity against highly resistant clinical isolates of Pseudomonas aeruginosa. Overall, this study proclaims that HS-loaded topical preparations could be a valuable product that serves as adjuvants to accelerate burn wound healing through inactivating the TLR4 pathway.

Simultaneous Administration of Hyperbaric Oxygen Therapy and Antioxidant Supplementation with Filipendula ulmaria Extract in the Treatment of Thermal Skin Injuries Alters Nociceptive Signalling and Wound Healing

“…Recently, some antioxidant-rich natural products were examined for their impact on wound healing. It has been shown that some of them induce an increase in tissue repair, which is accompanied by increased levels of wound contracture, hydroxyproline, hexosamine, fibrocytes, fibroblasts, as well as better re-epithelialization, higher collagen deposition, enhanced fibronectin content, and enhanced fibroblast cells [ 44 , 45 , 46 ].…”

Combination of Meropenem and Zinc Oxide Nanoparticles; Antimicrobial Synergism, Exaggerated Antibiofilm Activity, and Efficient Therapeutic Strategy against Bacterial Keratitis

“…Stocks were maintained in 20% ( v / v ) glycerol at −80 °C until needed. Bacterial strains were grown on Cetrimide agar (Sigma-Aldrich, St. Louis, MO, USA) overnight at 37 °C [ 47 ].…”

Naturally Occurring Antioxidants in Seven Well-Known Fruits from the Republic of Suriname (South America): Part 2

“…Furthermore, a polysaccharide-enriched crude extract from H. sabdariffa flower potently stimulated the proliferation of cultured keratinocytes [153], which may explain the addition of these preparations to H. sabdariffa skin care products. As well, a water in oil cream of the methanol extract of the calyces has been prepared as a potential commercial wound healing substance [154,155]. Preparations from H. sabdariffa calyx are also traditionally used in various countries including Suriname, for treating a broad range of conditions such as microbial infections, cough and bronchitis, kidney problems, various gastrointestinal conditions, and hypertension [49,151,156,157].…”