Emerging Concepts for Neuroscience Field from Ca2+/ cAMP Signalling Interaction

Bergantin, Leandro Bueno; Caricati‐Neto, Afonso

doi:10.17756/jnen.2017-024

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…cAMP signaling contributes to the adaptability of organelles such as mitochondria to changes in metabolic demands (Reggi & Diviani, 2017). Bergantin and Caricati‐Neto (2016) have reported the pathological regulation of cAMP signaling pathway in PD therapy, which further strengthens the validity of our results.…”

Section: Discussionsupporting

confidence: 86%

Nontargeted metabolomics reveals sequential changes in amino acid and ferroptosis‐related metabolism in Parkinson's disease

Xu,

Dai,

Tang

et al. 2024

Biomedical Chromatography

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Parkinson's disease (PD) is inseparable from metabolic disorders but lacks assessment of specific metabolite alteration. To explore the sequential metabolic changes in PD progression, we evenly divided 78 C57BL/6 mice (10 weeks) into six groups (one control group and five experimental groups) and collected the hippocampus tissue of mice after treating with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine, and probenecid (twice a week) at five periods (1, 2, 3, 4, and 5 weeks) for metabolome analysis. Our study identified 567 differentially abundant metabolites (DAMs) (total 4348 metabolites). Compared with controls, 145, 146, 171, 208, and 213 DAMs were obtained from the five experimental groups, respectively. Notably, 40 shared DAMs were present in five experimental groups, of which 22 shared DAMs formed a new metabolic network based on amino acid metabolism. Compared with group W3, 84 DAMs were identified in group W5, including 12 unique DAMs. DAMs in different stages of PD were significantly enriched in amino acid metabolism pathway, lipid metabolism pathway, and ferroptosis pathway. l‐Glutamine, spermidine, and l‐tryptophan were the key hubs in the whole metabolic process of PD. N‐Formyl‐l‐methionine gradually increased in abundance with PD progression, whereas 5‐methylcytosine gradually decreased. The study emphasized the sequential changes in DAMs in PD progression, stimulating subsequent studies.

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Section: Discussionsupporting

confidence: 86%