Emerging Issues in Pediatric Asthma: Gaps in EPR-3 Guidelines for Infants and Children

Abstract

There are many complexities to the treatment of infants and children with recurrent wheezing and asthma. NHLBI’s Expert Panel Report-3 (EPR3), published in 2007, provides guidance to clinicians who care for infants and children with asthma. Since that time, many important clinical trials have further informed the evidence base available to clinicians. In this manuscript, new approaches to long-term therapy, intermittent fixed-dose and dynamic dose therapies, and emerging therapies for asthma are reviewed. Further, additional gaps in guideline-base care and areas for future research are discussed.