Emerging neo adjuvants for harnessing therapeutic potential of M1 tumor associated macrophages (TAM) against solid tumors: Enusage of plasticity

Nadella, Vinod; Garg, Manoj; Kapoor, Sonia; Barwal, Tushar Singh; Jain, Aklank; Prakash, Hridayesh

doi:10.21037/atm-20-695

Cited by 17 publications

(8 citation statements)

References 91 publications

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“…The M1 phenotype is induced by contact with pathogen-associated molecular patterns (PAMPs) and alarmins (danger-associated molecular patterns, DAMPs). M1 macrophages express molecules involved in antigen presentation and induce the production of proinflammatory mediators [ 10 , 11 , 12 ].…”

Section: Gut Macrophages and Inflammationmentioning

confidence: 99%

Gut Microbiota Crosstalk with Resident Macrophages and Their Role in Invasive Amebic Colitis and Giardiasis—Review

2023

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The innate immune response is highly dependent on the action of macrophages. They are abundant in the intestine subepithelial lamina propria of the mucosa, where they deploy multiple tasks and play a critical role. The balance between the gut microbiota and M2 macrophages is critical for gut health and homeostasis. Gut microbiota has the power to change macrophage phenotype and replenish the resident macrophage niche during and post infection. As far as the extracellular enteric parasitic infections invasive amebic colitis and giardiasis are concerned, a change of macrophages phenotype to a pro-inflammatory state is dependent on direct contact of the protozoan parasites with host cells. Macrophages induce strong pro-inflammatory response by inflammasome activation and secretion of interleukin IL-1β. Inflammasomes play a key role in the response to cellular stress and microbe attacks. The balance between gut mucosal homeostasis and infection is dependent on the crosstalk between microbiota and resident macrophages. Parasitic infections involve NLRP1 and NLRP3 inflammasome activation. For Entamoeba histolytica and Giardia duodenalis infections, inflammasome NLRP3 activation is crucial to promote the host defenses. More studies are needed to further elucidate possible therapeutic and protective strategies against these protozoan enteric parasites’ invasive infections in humans.

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Section: Gut Macrophages and Inflammationmentioning

confidence: 99%

Gut Microbiota Crosstalk with Resident Macrophages and Their Role in Invasive Amebic Colitis and Giardiasis—Review

2023

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“…Numerous studies have shown that TAMs can promote tumor progression through various mechanisms in many solid tumors, and that TAMs number is significantly negatively correlated with patient prognosis ( Nadella et al, 2020 ). Immunotherapy targeting TAMs has become a potential strategy for anti-tumor therapy based on the tumor-promoting mechanism of TAMs.…”

Section: Immunotherapy Targeting Tumor-associated Macrophagesmentioning

confidence: 99%

The role of tumor-associated macrophages in oral squamous cell carcinoma

et al. 2022

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Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article reviews the origin, and the role of TAMs in the invasion, metastasis, angiogenesis and immunosuppression of OSCC. Therapeutic strategies targeting TAMs are also discussed in hopes of providing new ideas for the treatment of OSCC.

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“…Clinical evidence suggests that the presence of macrophages within the tumor microenvironment is associated with unfavorable outcomes in individuals with cancer ( 13 ). Macrophages are a highly heterogeneous group of immune cells with different functions and phenotypes that participate in both innate and adaptive immunity in the body ( 14 ). Macrophages exhibit both antitumor and pro-tumor effects.…”

Section: Introductionmentioning

confidence: 99%

“…Under conditions of tumorigenesis, macrophages have an antitumor effect, whereas once a tumor has formed, they have a pro-tumor effect ( 15 ). Under the influence of the complex tumor microenvironment, macrophages can be recruited to the tumor area and polarized into either a tumor growth-inhibiting M1 state or a tumor growth-promoting M2 state ( 14 , 16 ). In the present study, TAMs represent M2 type-associated tumor cells.…”

Section: Introductionmentioning

confidence: 99%

A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA‑MB‑231 triple‑negative breast cancer cells

Gao,

Ding,

Tang

2024

Mol Clin Oncol

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Breast cancer is a common tumor encountered in women, and triple-negative breast cancer (TNBC) has an extremely poor prognosis. The effect of leptin on the docetaxel sensitivity of MDA-MB-231 TNBC cells has not been investigated. The present study aimed to clarify the effect of leptin and M2 tumor-associated macrophages (TAMs) on the chemosensitivity of TNBC cell lines and its possible mechanisms. In the present study, the apoptosis of the MDA-MB-231 cell line was detected at 0, 24, 48 and 72 h using a Cell Counting Kit-8 assay to determine the appropriate concentration of docetaxel as well as the IC 50 value. After determining the effect of leptin on TAMs, the conditioned medium with an appropriate concentration of docetaxel was collected to treat the breast cancer cells, and flow cytometry was used to detect the cell cycle distribution and apoptosis in different treatment groups. Interleukin 8 (IL-8) expression was detected using ELISA and western blot assay. The IL-8 antibody was used to neutralize IL-8, and invasion and scratch assays were used to detect changes in invasion and migration of breast cancer cells. Statistical analysis was performed using GraphPad Prism 9.0 and SPSS 22.0. It was revealed that the apoptotic rate of MDA-MB-231 cells in the leptin-treated TAMs group was lower than that in other groups. The expression of IL-8 was notably elevated in the group treated with leptin-activated TAMs compared with that in the other groups. The neutralization of IL-8 resulted in a significant reduction in the invasive migration of MDA-MB-231 cells compared with that in the non-neutralized group.

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Emerging neo adjuvants for harnessing therapeutic potential of M1 tumor associated macrophages (TAM) against solid tumors: Enusage of plasticity

Cited by 17 publications

References 91 publications

Gut Microbiota Crosstalk with Resident Macrophages and Their Role in Invasive Amebic Colitis and Giardiasis—Review

Gut Microbiota Crosstalk with Resident Macrophages and Their Role in Invasive Amebic Colitis and Giardiasis—Review

The role of tumor-associated macrophages in oral squamous cell carcinoma

A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA‑MB‑231 triple‑negative breast cancer cells

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