2019
DOI: 10.1016/j.jconrel.2019.02.031
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Emerging paradigms in nanotechnology for imaging and treatment of cerebral ischemia

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Cited by 58 publications
(40 citation statements)
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“…It is clear that the changes that occurred in CBF and SUVR were more dramatic in the synchronous region than in either the CBF-decreased areas alone or the SUVR-decreased areas alone. Ischaemic cerebrovascular disease is a fatal condition that arises due to insufficient blood flow and metabolic impairment to damages brain cells [43,44]. Theoretically, vascular stenosis or occlusion immediately affected perfusion and causes metabolic changes in the area of the vascular distribution.…”
Section: Discussionmentioning
confidence: 99%
“…It is clear that the changes that occurred in CBF and SUVR were more dramatic in the synchronous region than in either the CBF-decreased areas alone or the SUVR-decreased areas alone. Ischaemic cerebrovascular disease is a fatal condition that arises due to insufficient blood flow and metabolic impairment to damages brain cells [43,44]. Theoretically, vascular stenosis or occlusion immediately affected perfusion and causes metabolic changes in the area of the vascular distribution.…”
Section: Discussionmentioning
confidence: 99%
“…Most neuroprotectant showed limited effects in treating ischemic stroke for their short half-lives, potential toxicity, poor specificity of distribution, as well as low targeting efficiency to cross the BBB to achieve effective drug accumulation at the aimed lesions. 52 For instance, the half-life of edaravone in vivo is as short as 5.4 min, which seriously hinders the effectiveness of the agent. In addition, biological macromolecules such as superoxide dismutase (SOD) which could efficiently eliminate ROS, and cyclosporine A (CsA) which could inhibit the inflammatory response, have exhibited fine protective effect on damaged neurons.…”
Section: Traditional Treatment Strategiesmentioning
confidence: 99%
“…In recent years, nanotechnology approaches have demonstrated a promising possibility to improve the pharmacokinetics and biodistribution profile of many drugs. [21,23,24] Some studies have shown that the pH gradients between ischemic and normal tissues are used to achieve targeted release. [25] However, the instability of the local environment and the physiological state of other parts of the body limits the release of drugs.…”
Section: Introductionmentioning
confidence: 99%
“…Although the above pathways are effective in regulating angiogenesis, there are still challenges in drug delivery. [ 21 ] As BBB precludes most drugs from entering the brain, many agents are forced to be administered in an invasive manner. Even though BBB can be compromised after ischemic insults, the extent of damage to the integrity of BBB can often not satisfy adequate drug enrichment for treatment.…”
Section: Introductionmentioning
confidence: 99%