Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Jia, Bo; Zhang, Beibei; Li, Jianhua; Qin, Jinlong; Huang, Yisheng; Huang, Mingshu; Ming, Yue; Jiang, Jingjing; Chen, Ran; Xiao, Yufen; Du, Jianzhong

doi:10.1039/d3cs01039b

Chem. Soc. Rev.

2024

DOI: 10.1039/d3cs01039b

|View full text |Cite

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Bo Jia,

Beibei Zhang,

Jianhua Li

et al.

Abstract: We highlight the recent progress and design strategies of polymeric materials with tailored functions to overcome the highly movable and wet, microbial and inflammatory environment in the oral cavity for treatment of oral diseases.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 7 publications

References 282 publications

(344 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Adaptable Hydrogel with Strong Adhesion of Wet Tissue for Long‐Term Protection of Periodontitis Wound

Chen,

Zhao,

Zhang

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

Periodontitis is a severe gum infection characterized by inflammation of the tissues surrounding the teeth. The disease is challenging to manage due to its exposure to a wet and dynamic oral environment, where conventional hydrogels often suffer from weak adhesion, short residence time, and vulnerability to bacterial invasion. In this study, an innovative hydrogel system based on in situ light curing is proposed. The hydrogel precursor, comprising sodium alginate and a calcium ion network, is designed and adhere to the irregular and smooth surfaces of periodontal tissue before curing. Upon light irradiation, a second network polymerizes rapidly, establishing multiple interactions with the tissue, which enhances adhesion strength. Benefited from this engineering strategy, the hydrogel exhibits a low swelling rate, effectively mitigating adhesion loss in the moist oral environment. Additionally, the hydrogel demonstrates excellent long‐lasting wet adhesion, maintaining its presence in periodontal tissue over 120 hours. It also serves as an effective physical barrier against bacterial invasion, achieving a blocking efficiency of 99.9%. This novel design concept offers a promising approach for developing advanced medical dressings for periodontitis, providing sustained therapeutic benefits.

show abstract

Adaptable Hydrogel with Strong Adhesion of Wet Tissue for Long‐Term Protection of Periodontitis Wound

Chen,

Zhao,

Zhang

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

show abstract

Dual-functional core–shell microneedle patches for oral ulcers treatment

Tang,

Song,

et al. 2024

Chemical Engineering Journal

View full text Add to dashboard Cite

Hydrogel design and applications for periodontitis therapy: A review

Pan,

Zong,

et al. 2025

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Abstract: We highlight the recent progress and design strategies of polymeric materials with tailored functions to overcome the highly movable and wet, microbial and inflammatory environment in the oral cavity for treatment of oral diseases.

Cited by 7 publications

References 282 publications

Adaptable Hydrogel with Strong Adhesion of Wet Tissue for Long‐Term Protection of Periodontitis Wound

Adaptable Hydrogel with Strong Adhesion of Wet Tissue for Long‐Term Protection of Periodontitis Wound

Dual-functional core–shell microneedle patches for oral ulcers treatment

Hydrogel design and applications for periodontitis therapy: A review

Contact Info

Product

Resources

About