Emerging prediction methods for early diagnosis of necrotizing enterocolitis

Wu, Siyuan; Di, Sijia; Liu, Tianjing; Shi, Yonghui

doi:10.3389/fmed.2022.985219

Cited by 4 publications

(2 citation statements)

References 101 publications

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“…The intestinal microbiota related to the occurrence and development of NEC has also been profoundly investigated [ 79 ]. These emerging prediction methods for early diagnosis of NEC mentioned above have been systematically reviewed recently [ 80 ].…”

Section: Treatment Of Necmentioning

confidence: 99%

“…Unlike the sudden appearance of overt clinical signs in midto late-stage disease, the onset of NEC is often subtle and insidious; therefore, many researchers have attempted to Mild or suspected NEC NPO status [70], pay attention to refeeding time [71,72] Biomarker screening to help confirm or rule out suspected NEC [19,80] Potential biomarkers Urine I-FABP [73] Intestinal I-FABP, claudin-3 [73] or inter-α inhibitor protein [74] Stool calprotectin [73,75,76] Ultrasound [77], NIRS [78] or microbiota [79] Multi-signal scoring systems ApoSAA [81] Integrated fecal calprotectin and urinary I-FABP [82] Urine rintso2 and intestinal I-FABP [83] Intestinal and stool IAP [84] Omics technologies [85] Metabolomics [86][87][88][89] Proteomics [90][91][92][93][94][95] Integrated metabolomics with either proteomics [96] or metagenomics [87, 97, 98] Nutritional support Enteral feeding time [99,100] Breast milk [101,102] Recognized nutrient components Mucosal integrity [104]: exosomes [110][111][112] Immune function [104]: IgA [105], Oligosaccharides [106], Exosomes [107-109] Donor breast milk …”

Section: Biomarker Screening For the Early Identification Of Necmentioning

confidence: 99%

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Necrotizing enterocolitis: current understanding of the prevention and management

Hu,

Liang,

et al. 2024

Pediatr Surg Int

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Necrotizing enterocolitis (NEC) is one of the diseases in neonates, with a high morbidity and mortality rate, especially in preterm infants. This review aimed to briefly introduce the latest epidemiology, susceptibility factors, and clinical diagnosis and presentation of NEC. We also organized new prevention strategies by risk factors according to different pathogeneses and then discussed new treatment methods based on Bell's staging and complications, and the classification of mild to high severity based on clinical and imaging manifestations. Such a generalization will help clinicians and researchers to gain a deeper understanding of the disease and to conduct more targeted classification, grading prevention, and exploration. We focused on prevention and treatment of the early and suspected stages of NEC, including the discovery of novel biomarkers and drugs to control disease progression. At the same time, we discussed its clinical application, future development, and shortcomings.

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Section: Treatment Of Necmentioning

confidence: 99%

Section: Biomarker Screening For the Early Identification Of Necmentioning

confidence: 99%

Necrotizing enterocolitis: current understanding of the prevention and management

Hu,

Liang,

et al. 2024

Pediatr Surg Int

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Research Advances in Serum Protein Markers for Predicting Surgical Management of Necrotizing Enterocolitis

向

2024

ACM

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The value of D-dimer and platelet-lymphocyte ratio combined with CT signs for predicting intestinal ischemia in patients with bowel obstruction

Zhou,

Zhao,

Liu

et al. 2024

PLoS ONE

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Objective To investigate the diagnostic value of D-dimer, platelet-lymphocyte rate (PLR) and CT signs for intestinal ischemia in patients with bowel obstruction. Methods We retrospectively analyzed the clinical and imaging data of 105 patients diagnosed with bowel obstruction, and performed univariate and multivariate analyses to determine the independent risk factors for intestinal ischemia in patients with bowel obstruction. Moreover, the receiver operating characteristic curve (ROC) was plotted to examine the diagnostic value of D-dimer, PLR and CT signs in patients with bowel obstruction. Besides, Kappa tests were used to assess inter-observer agreement. Results We included 56 men (53%) and 49 women (47%) with mean age of 66.05 ± 16 years. Univariate and multivariate analyses showed that D-dimer, PLR and two significant CT signs (i.e., increased unenhanced bowel-wall attenuation and mesenteric haziness) were independent risk factors for intestinal ischemia in patients with bowel obstruction. ROC analysis showed that the combined use of D-dimer, PLR and the said two CT signs had better performance than single indicators in predicting intestinal ischemia in patients with bowel obstruction. The area under the curve (AUC) of the joint model III was 0.925 [95%CI: 0.876–0.975], with a sensitivity of 79.2% [95CI%: 67.2–91.1] and a specificity of 91.2% [95%CI: 83.7–98.9]. Conclusion The combined use of D-dimer, PLR and CT signs has high diagnostic value for intestinal ischemia in patients with bowel obstruction and will prompt surgical exploration to evaluate intestinal blood flow.

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Emerging prediction methods for early diagnosis of necrotizing enterocolitis

Cited by 4 publications

References 101 publications

Necrotizing enterocolitis: current understanding of the prevention and management

Necrotizing enterocolitis: current understanding of the prevention and management

Research Advances in Serum Protein Markers for Predicting Surgical Management of Necrotizing Enterocolitis

The value of D-dimer and platelet-lymphocyte ratio combined with CT signs for predicting intestinal ischemia in patients with bowel obstruction

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