Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities

Liu, Chuan; Zhao, Guo; Qiao, Danni; Wang, Lintao; He, Yeling; Zhao, Mingge; Fan, Yuanyuan

doi:10.3389/fmed.2021.809270

Cited by 35 publications

(45 citation statements)

References 187 publications

(254 reference statements)

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“…Liu et al [ 13 ] stated in their study that not only hCG but also many different cytokines are secreted from trophoblasts in chorionic villi, and hCG alone may not be responsible for nausea and vomiting. For example, in a study by Fejzo M.S et al [ 14 ] it was found that the GDF-15 gene encodes a TGF-β superfamily member, which is expressed at high levels in the trophoblast cells of the placenta, and this protein, which has high levels in maternal blood especially in the first two trimesters, acts to facilitate placentation and suppress pro-inflammatory production of cytokines in order to suppress the continuation of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum

Timur

Güney

2022

BMC Pregnancy Childbirth

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Background We aimed to investigate the levels of ADAMTS-1, which is secreted from the extracellular matrix during trophoblastic invasion in hyperemesis gravidarum (HEG). Methods In this cross-sectional study, we compared 45 HEG patients aged between 21 and 34 in terms of ADAMTS-1 levels with a control group consisting of 44 healthy pregnant women. The demographic characteristics and several laboratory parameters of the patients were recorded. Both groups were also compared in terms of ketonuria. We evaluated the correlation between ADAMTS-1 levels and ketonuria. Results The 2 groups were matched in terms of age, gestational age, gravidity, parity, and body mass index. Some inflammatory markers, such as neutrophil count, MPV, PDW, and PCT levels, were significantly higher in the HEG groups compared to the control group (all p < 0.05). However, mean MCV and serum TSH levels were statistically significantly lower in this group (both p < 0.001). ADAMTS-1 levels were 12.6 ± 1.4 ng/ml in the HEG group and 6.2 ± 1.6 ng/ml in the control group (p < 0.001). It was significantly and positively correlated with urine ketone, neutrophil count, and PDW, whereas negatively correlated with MCV and TSH value in the HEG group. ROC analysis showed that a threshold value of 11.275 ng/ml for ADAMTS-1 predicted HEG patients with a sensitivity of 60% and specificity of 95.5%. Conclusion ADAMTS-1 serum levels are increased in HEG patients, and there is a positive correlation between ADAMTS-1 levels and ketonuria.

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Section: Discussionmentioning

confidence: 99%

The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum

Timur

Güney

2022

BMC Pregnancy Childbirth

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“…Pregnant women who experience complaints of nausea and vomiting are natural symptoms that will be felt in the first trimester, usually, the mother will experience signs or symptoms such as dizziness, excessive salivation, and expelling some food and even everything that has been consumed. In addition, in many cases, pregnant women experience excessive nausea and vomiting which can worsen the general condition of the mother and can interfere with the daily activities of pregnant women (Dunbar et al, 2022;Liu et al, 2022). Nausea and vomiting in pregnancy can have serious consequences for the mother and especially the fetus.…”

Section: Discussionmentioning

confidence: 99%

Pericardial Acupressure (P6) to reduce nausea and vomiting for pregnant women

Sari

Hindratni

2022

JurKebMal

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Latar Belakang: Mual dan muntah kehamilan adalah komplikasi kehamilan yang paling umum terjadi pada 85% ibu hamil . Tingginya kadar hormon hCG pada kehamilan diduga menjadi penyebab mual dan muntah. Akupresure merupakan perkembangan terapi pijat yang berlangsung seiring dengan perkembangan ilmu akupuntur. Akupresur pada titik nerikardium 6 dapat mengurangi mual dan muntah karena dari stimulasi tersebut dapat meningkatkan pelepasan beta-endorphin.Tujuan : Untuk mengetahui pengaruh akupresu P6 untuk megurangi mual dan muntah pada ibu hamil..Metode: Penelitian ini merupakan penelitian pra eksperiment dengan menggunakan desain penelitian one group pre-post-test design. Pendekatan yang digunakan adalah cross sectional. Penelitian ini dilakukan di Klinik Taman Sari 6 Kota Pekanbaru. Populasi dalam penelitian ini adalah seluruh ibu hamil yang melakukan pemeriksaan kehamilan di klinik Taman Sari bulan Februari – Juli 2022. Teknik pengambilan sampel menggunakan total sampling yang berjumlah 25 orang. Penelitian dilakukan dengan cara kunjungan rumah, selanjutnya dilakukan informed consent dan pre-test setelah itu di lakukan akupresure dalam waktu 3 hari pada pagi hari dan setelah hari ke 3 dilakukan post-test. Instrumen dalam penelitian ini Lembar kuesioner Pregnancy- Unique Quantification of Emesis-24 (PUQE 24). Analisa data secara univariat dan bivariate dengan Uji T-Test.Hasil : Hasil penelitian didapatkan rata-rata frekuensi mual dan muntah sebelum diberikan akupresur pada titik perikardium 6 adalah sebesar 2.56 (SD 0.51) dan sesudah diberikan akupresur pada titik perikardium 6 terjadi penurunan frekuensi mual dan muntah dengan nilai rata-rata sebesar 2,04 (SD 0.35). Hasil Uji Two Sample T Test menunjukkan bahwa ada pengaruh akupresur pada titik perikardium 6 (p-0,000).Kesimpulan: ada pengaruh akupresu P6 untuk megurangi mual dan muntah pada ibu hamil..Saran : Untuk menjaga kehamilan berjalan denga naman, ibu hamil tidak boleh mengesampingan keluhan yang dirasakan termasuk mual-dan muntah karena dapat menjadi masalah serius. Akupresur merupakan pengobatan non-invasif yang baik diambil oleh ibu hamil untuk mengurangi mual dan muntah. Kata Kunci : mual, muntah, acupresur P6, ibu hamil ABSTRACT Background: Nausea and vomiting during pregnancy are the most common pregnancy complications that occur in 85% of pregnant women. High levels of the hormone hCG in pregnancy are thought to be the cause of nausea and vomiting. Acupressure is the development of massage therapy that goes hand in hand with the development of acupuncture. Acupressure at the point of pericardium 6 can reduce nausea and vomiting because the stimulation can increase the release of beta-endorphin.Purpose: To determine the effect of P6 acupressure to reduce nausea and vomiting in pregnant women.Method: This research is a pre-experimental study using a one-group pre-post-test research design. The approach used is cross-sectional. This research was conducted at Taman Sari 6 Clinic, Pekanbaru City. The population in this study were all pregnant women who had a pregnancy check-up at the Taman Sari clinic from February to July 2022. The sampling technique used a total sampling of 25 people. The instrument in this study was the Pregnancy- Unique Quantification of Emesis-24 (PUQE 24) questionnaire. Data analysis was univariate and bivariate with the T-Test.Results: The results showed that the average frequency of nausea and vomiting before being given acupressure at the pericardium 6 was 2.56 (SD 0.51) and after being given acupressure at the pericardium 6 there was a decrease in the frequency of nausea and vomiting with an average value of 2.04 ( SD 0.35). The results of the Two Sample T Test showed that there was an effect of acupressure on the 6th pericardial point (p-0.000).Conclusion: there is an effect of P6 acupressure to reduce nausea and vomiting in pregnant women.Suggestion: To keep the pregnancy going with the name, pregnant women should not put aside the complaints they feel, including nausea and vomiting because they can be a serious problem. Acupressure is a non-invasive treatment that is good for pregnant women to reduce nausea and vomiting. Keywords: Nausea,Pregnant Women, P6 Acupressure,Vomiting

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“…[52][53][54] Psychological symptoms such as anxiety and depression seem to be an outcome of the tension and the body burden of HG, rather than a reason. 55,56 Patients with HG were 5.5 and 6.7 times more vulnerable to fulfill the criteria for depression and anxiety disorder compared with comparative group, respectively. 57 To those with prolonged HG, several conditions including anxiety (32%) and PTSD (13%) were more likely to report.…”

Section: Hyperemesis Gravidarummentioning

confidence: 91%

Psychologic Sequelae in Early Pregnancy Complications

Jia¹,

Li²,

Liu³

et al. 2023

IJWH

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Early pregnancy complications, including miscarriage, ectopic pregnancies, and hyperemesis gravidarum, are common discomforts accounting for about 15% to 20% of all pregnancies. A proportion of women with early pregnancy complications will experience short-and long-term psychologic sequelae in the aftermath of pregnancy complications, including anxiety, depression, and post-traumatic stress disorder (PTSD) which are the most commonly reported psychologic reactions. This review will focus on the course and impact of these psychologic sequelae in early pregnancy complications, and the noninvasive interventions to improve mental health are also briefly discussed.

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Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities

Cited by 35 publications

References 187 publications

The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum

The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum

Pericardial Acupressure (P6) to reduce nausea and vomiting for pregnant women

Psychologic Sequelae in Early Pregnancy Complications

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