Emerging regenerative medicine for hemorrhagic stroke: An update on stem cell therapies

Monsour, Molly; Borlongan, Cesario V.

doi:10.1016/j.hest.2022.07.001

Cited by 4 publications

(1 citation statement)

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“…Moreover, as the field of stem cells advances, the source of NSCs for transplantation has expanded from direct isolation of brain tissue initially to differentiation from pluripotent stem cells (PSCs) and transdifferentiation of somatic cells. So far, NSC-based therapies have been implemented in many rodent models of NDs and ischemic stroke, and several studies proposed potential mechanisms to explain the disease-improving effects of NSCs, including neuroinflammation inhibition, neuronal replacement, immunomodulation and neurotrophic support, which promotes the recovery of ND and stroke models [ 14 – 18 ]. Now clinical trials exploring the feasibility of NSCs treatment for neurological diseases are being conducted.…”

Section: Introductionmentioning

confidence: 99%

Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke

et al. 2023

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Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, especially neurodegenerative disorders and stroke, characterized by irreversible cellular damage are often considered as refractory diseases. Neural stem cells (NSCs) play a unique role in the treatment of neurological diseases for their abilities to self-renew and form different neural lineage cells, such as neurons and glial cells. With the increasing understanding of neurodevelopment and advances in stem cell technology, NSCs can be obtained from different sources and directed to differentiate into a specific neural lineage cell phenotype purposefully, making it possible to replace specific cells lost in some neurological diseases, which provides new approaches to treat neurodegenerative diseases as well as stroke. In this review, we outline the advances in generating several neuronal lineage subtypes from different sources of NSCs. We further summarize the therapeutic effects and possible therapeutic mechanisms of these fated specific NSCs in neurological disease models, with special emphasis on Parkinson’s disease and ischemic stroke. Finally, from the perspective of clinical translation, we compare the strengths and weaknesses of different sources of NSCs and different methods of directed differentiation, and propose future research directions for directed differentiation of NSCs in regenerative medicine.

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Section: Introductionmentioning

confidence: 99%