2017
DOI: 10.1155/2017/8081758
|View full text |Cite
|
Sign up to set email alerts
|

Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders

Abstract: Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with specialized functions that are regulated in space and time to allow synaptic plasticity. However, their interplay during neuronal development, learning, and memory is poorly understood. Accumulating evidence links synap… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

2
58
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
4
3
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 67 publications
(60 citation statements)
references
References 289 publications
(323 reference statements)
2
58
0
Order By: Relevance
“…Decreased expression of hippocampal nr4a2 in crows with reduced NOE is also consistent with its suggested role in the novel object recognition and memory in mice (McNulty et al., ). At the same time, the lack of dLAN‐induced effect on expression of genes involved in neuronal plasticity ( egr1 , creb , syngap , syn2 , grin2a , and grin2b ) and neuronal death ( caspase2 , caspase3 , foxo3 ) do not support the changes in neuronal plasticity and apoptosis as possible factors for negative behavioural responses in Indian house crows under dLAN (Duclot & Kabbaj, ; Lee et al., ; Torres, Vallejo, & Inestrosa, ). We would not rule out though the other possibilities, e.g., (a) the involvement of other genes that we have not investigated, and (b) dLAN‐induced alteration of post‐transcriptional events and post‐translational modification of the protein target.…”
Section: Discussionmentioning
confidence: 99%
“…Decreased expression of hippocampal nr4a2 in crows with reduced NOE is also consistent with its suggested role in the novel object recognition and memory in mice (McNulty et al., ). At the same time, the lack of dLAN‐induced effect on expression of genes involved in neuronal plasticity ( egr1 , creb , syngap , syn2 , grin2a , and grin2b ) and neuronal death ( caspase2 , caspase3 , foxo3 ) do not support the changes in neuronal plasticity and apoptosis as possible factors for negative behavioural responses in Indian house crows under dLAN (Duclot & Kabbaj, ; Lee et al., ; Torres, Vallejo, & Inestrosa, ). We would not rule out though the other possibilities, e.g., (a) the involvement of other genes that we have not investigated, and (b) dLAN‐induced alteration of post‐transcriptional events and post‐translational modification of the protein target.…”
Section: Discussionmentioning
confidence: 99%
“…They participate in synaptogenesis by helping to stabilize synapses early in development during the formation of neural circuits and simultaneously contribute to the specification of the diverse properties of synapses (1)(2)(3). Because of their central role in synaptic function, mutations in synaptic cell adhesion proteins contribute to a wide range of neuropsychiatric disorders (2,(4)(5)(6)(7)(8).…”
mentioning
confidence: 99%
“…The indispensable role of SNAREs in NT release accords with the rarity of mutations in any of these proteins 7 . However, mutations in the direct regulators of SNARE proteins exhibit a range of clinical presentations, including autism spectrum disorder (ASD), schizophrenia, and an array of other neurological disorders 8 . Although the genetic variation underlying the clinical phenotype can be directly identified, there is no straightforward approach linking the observed mutation effect with the protein stability, interactions, and dynamics of the cellular processes involved in synaptic function.…”
Section: Main Textmentioning
confidence: 99%